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Sökning: onr:"swepub:oai:DiVA.org:umu-198043" > Repository of intra...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00006253naa a2200613 4500
001oai:DiVA.org:umu-198043
003SwePub
008220715s2022 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1980432 URI
0247 a https://doi.org/10.1515/cclm-2022-04112 DOI
040 a (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Dragon-Durey, Marie-Agnèsu Laboratoire d'Immunologie, Hôpital Européen Georges Pompidou, APHP, Université de Paris Cité, Paris, France4 aut
2451 0a Repository of intra-and inter-run variations of quantitative autoantibody assays: A European multicenter study
264 c 2022-06-24
264 1b De Gruyter Open,c 2022
338 a print2 rdacarrier
520 a No reference data are available on repositories to measure precision of autoantibody assays. The scope of this study was to document inter-and intra-run variations of quantitative autoantibody assays based on a real-world large international data set. Members of the European Autoimmunity Standardisation Initiative (EASI) group collected the data of intra-and inter-run variability obtained with assays quantifying 15 different autoantibodies in voluntary participating laboratories from their country. We analyzed the impact on the assay performances of the type of immunoassay, the number of measurements used to calculate the coefficient of variation (CVs), the nature and the autoantibody level of the internal quality control (IQC). Data were obtained from 64 laboratories from 15 European countries between February and October 2021. We analyzed 686 and 1,331 values of intra-and inter-run CVs, respectively. Both CVs were significantly dependent on: The method of immunoassay, the level of IQC with higher imprecision observed when the antibody levels were lower than 2-fold the threshold for positivity, and the nature of the IQC with commercial IQCs having lower CVs than patients-derived IQCs. Our analyses also show that the type of autoantibody has low impact on the assay' performances and that 15 measurements are sufficient to establish reliable intra-and inter-run variations. This study provides for the first time an international repository yielding values of intra-and inter-run variation for quantitative autoantibody assays. These data could be useful for ISO 15189 accreditation requirements and will allow clinical diagnostic laboratories to assure quality of patient results.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Klinisk laboratoriemedicin0 (SwePub)302232 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Clinical Laboratory Medicine0 (SwePub)302232 hsv//eng
653 a immunoassay
653 a inter-run variation
653 a internal quality control
653 a intra-run variation
653 a laboratory accreditation
653 a precision
653 a quality assurance
7001 a Bizzaro, Nicolau Laboratory of Clinical Pathology, San Antonio Hospital, Azienda Sanitaria Universitaria Integrata, Udine, Italy4 aut
7001 a Senant, Marieu Cerballiance, Lisses, France4 aut
7001 a Andreeva, Hristinau Section of Protein Allergy and Immunology, Laboratory Medicine Department, Diagnostic Clinic, University Hospital of North Norway, Tromsø, Norway4 aut
7001 a Bogdanos, Dimitrios P.u Department of Rheumatology and Clinical Immunology, Fac. of Med., Sch. of Hlth. Sciences, University of Thessaly, University General Hospital of Larissa, Larissa, Greece4 aut
7001 a Bonroy, Carolienu Department of Diagnostic Sciences, Ghent University, Ghent, Belgium4 aut
7001 a Bossuyt, Xavieru Department of Microbiology, Immunology and Transplantation, Ku Leuven, Belgium4 aut
7001 a Eriksson, Catharina,d 1955-u Umeå universitet,Klinisk immunologi4 aut0 (Swepub:umu)caaern74
7001 a Fabien, Nicoleu Immunology Department, Hospices Civils de Lyon, Pierre-Bénite, France4 aut
7001 a Heijnen, Ingmaru Medical Immunology, Laboratory Medicine, University Hospital Basel, Basel, Switzerland4 aut
7001 a Herold, Manfredu Rheumatology Laboratory, Department of Internal Medicine Ii, Medical University of Innsbruck, Innsbruck, Austria4 aut
7001 a Musset, Lucileu Département d'Immunologie, Uf Immunochimie and Autoimmunité, Chu Pitié Salpêtrière-Ch Foix, Aphp, Paris, France4 aut
7001 a Kuhi, Liisau Central Laboratory, Diagnostic Clinic, East Tallinn Central Hospital, Tallinn, Estonia4 aut
7001 a Lopez-Hoyos, Marcosu Servicio de Inmunología, Hospital Universitario Marqués de Valdecilla, Santander, Cantabria, Spain4 aut
7001 a Berki, Tímeau Department of Immunology and Biotechnology, University of Pécs, Medical School, Pécs, Hungary4 aut
7001 a Roozendaal, Carolineu Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, Netherlands4 aut
7001 a Sack, Ulrichu Medical Faculty, Institute of Clinical Immunology, University Leipzig, Leipzig, Germany4 aut
7001 a Sundic, Tatjanau Immunology and Transfusion Medicine, Department of Laboratory Medicine, Haugesund Hospital, Haugesund, Norway4 aut
7001 a Taylor, Lornau Department of Immunology, Black Country Pathology Services, Wolverhampton, West Midlands, United Kingdom4 aut
7001 a Kuna, Andrea Tesijau Department of Clinical Chemistry, Sestre Milosrdnice University Hospital Center, Zagreb, Croatia4 aut
7001 a Damoiseaux, Janu Central Diagnostic Laboratory, Maastricht University Medical Center, Maastricht, Netherlands4 aut
7102 a Laboratoire d'Immunologie, Hôpital Européen Georges Pompidou, APHP, Université de Paris Cité, Paris, Franceb Laboratory of Clinical Pathology, San Antonio Hospital, Azienda Sanitaria Universitaria Integrata, Udine, Italy4 org
7730 t Clinical Chemistry and Laboratory Medicined : De Gruyter Openg 60:9, s. 1373-1383q 60:9<1373-1383x 1434-6621x 1437-4331
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-198043
8564 8u https://doi.org/10.1515/cclm-2022-0411

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