Sökning: onr:"swepub:oai:DiVA.org:umu-199386" > Cigarette Smoking a...
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000 | 10269naa a2200793 4500 | |
001 | oai:DiVA.org:umu-199386 | |
003 | SwePub | |
008 | 220930s2022 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1993862 URI |
024 | 7 | a https://doi.org/10.1158/1055-9965.EPI-21-11762 DOI |
040 | a (SwePub)umu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Dimou, Nikiu Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France4 aut |
245 | 1 0 | a Cigarette Smoking and Endometrial Cancer Risk :b observational and Mendelian Randomization Analyses |
264 | 1 | b American Association for Cancer Research,c 2022 |
338 | a electronic2 rdacarrier | |
520 | a BACKGROUND: Current epidemiologic evidence indicates that smoking is associated with a lower endometrial cancer risk. However, it is unknown if this association is causal or confounded. To further elucidate the role of smoking in endometrial cancer risk, we conducted complementary observational and Mendelian randomization (MR) analyses.METHODS: The observational analyses included 286,415 participants enrolled in the European Prospective Investigation into Cancer and Nutrition and 179,271 participants in the UK Biobank, and multivariable Cox proportional hazards models were used. In two-sample MR analyses, genetic variants robustly associated with lifetime amount of smoking (n = 126 variants) and ever having smoked regularly (n = 112 variants) were selected and their association with endometrial cancer risk (12,906 cancer/108,979 controls from the Endometrial Cancer Association Consortium) was examined.RESULTS: In the observational analysis, lifetime amount of smoking and ever having smoked regularly were associated with a lower endometrial cancer risk. In the MR analysis accounting for body mass index, a genetic predisposition to a higher lifetime amount of smoking was not associated with endometrial cancer risk (OR per 1-SD increment: 1.15; 95% confidence interval: 0.91-1.44). Genetic predisposition to ever having smoked regularly was not associated with risk of endometrial cancer.CONCLUSIONS: Smoking was inversely associated with endometrial cancer in the observational analyses, although unsupported by the MR. Additional studies are required to better understand the possible confounders and mechanisms underlying the observed associations between smoking and endometrial cancer. IMPACT: The results from this analysis indicate that smoking is unlikely to be causally linked with endometrial cancer risk. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng |
700 | 1 | a Omiyale, Wemimou Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom4 aut |
700 | 1 | a Biessy, Carineu Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France4 aut |
700 | 1 | a Viallon, Vivianu Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France4 aut |
700 | 1 | a Kaaks, Rudolfu Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany4 aut |
700 | 1 | a O'Mara, Tracy A.u Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, QLD, Brisbane, Australia4 aut |
700 | 1 | a Aglago, Elom K.u Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France4 aut |
700 | 1 | a Ardanaz, Evau Navarra Public Health Institute, Pamplona, Spain; IdiSNA, Navarra Institute for Health Research, Pamplona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Spain4 aut |
700 | 1 | a Bergmann, Manuela M.u German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany4 aut |
700 | 1 | a Bondonno, Nicola P.u Danish Cancer Society Research Center, Copenhagen, Denmark4 aut |
700 | 1 | a Braaten, Tonjeu Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway4 aut |
700 | 1 | a Colorado-Yohar, Sandra M.u CIBER Epidemiología y Salud Pública (CIBERESP), Spain; Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain; Research Group on Demography and Health, National Faculty of Public Health, University of Antioquia, Medellín, Colombia4 aut |
700 | 1 | a Crous-Bou, Martau Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO) - Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Department of Epidemiology, Harvard T.H. Chan School of Public Health. Boston, MA, United States4 aut |
700 | 1 | a Dahm, Christina C.u Department of Public Health, Aarhus University, Aarhus, Denmark4 aut |
700 | 1 | a Fortner, Renée Tu Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany4 aut |
700 | 1 | a Gram, Inger T.u Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway4 aut |
700 | 1 | a Harlid, Sophia,d 1978-u Umeå universitet,Obstetrik och gynekologi4 aut0 (Swepub:umu)soha0105 |
700 | 1 | a Heath, Alicia K.u Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom4 aut |
700 | 1 | a Idahl, Annika,d 1965-u Umeå universitet,Obstetrik och gynekologi4 aut0 (Swepub:umu)anid0002 |
700 | 1 | a Kvaskoff, Marinau UVSQ, Inserm CESP U1018, Gustave Roussy, Université Paris-Saclay, Villejuif, France4 aut |
700 | 1 | a Nøst, Therese H.u Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway4 aut |
700 | 1 | a Overvad, Kimu Department of Public Health, Aarhus University, Aarhus, Denmark4 aut |
700 | 1 | a Palli, Domenicou Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy4 aut |
700 | 1 | a Perez-Cornago, Aurorau Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom4 aut |
700 | 1 | a Sacerdote, Carlottau Unit of Cancer Epidemiology, Città della Salute e della Scienza University-Hospital, Turin, Italy4 aut |
700 | 1 | a Sánchez, Maria-Joseu Escuela Andaluza de Salud Pública (EASP), Granada, Spain; Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain4 aut |
700 | 1 | a Schulze, Matthias B.u Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; Institute of Nutritional Science, University of Potsdam, Potsdam, Germany4 aut |
700 | 1 | a Severi, Gianlucau UVSQ, Inserm CESP U1018, Gustave Roussy, Université Paris-Saclay, Villejuif, France; Department of Statistics, Computer Science, Applications "G. Parenti", University of Florence, Florence, Italy4 aut |
700 | 1 | a Simeon, Vittoriou Dipartimento di Salute Mentale e Fisica e Medicina Preventiva, University of Naples "L. Vanvitelli", Naples, Italy4 aut |
700 | 1 | a Tagliabue, Giovannau Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori Via Venezian 1, Milan, Italy4 aut |
700 | 1 | a Tjønneland, Anneu Department of Public Health, University of Copenhagen, Copenhagen, Denmark4 aut |
700 | 1 | a Truong, Thérèseu UVSQ, Inserm CESP U1018, Gustave Roussy, Université Paris-Saclay, Villejuif, France4 aut |
700 | 1 | a Tumino, Rosariou Hyblean Association for Epidemiological Research, Ragusa, Italy4 aut |
700 | 1 | a Johansson, Mattiasu Section of Genetics, International Agency for Research on Cancer, Lyon, France4 aut |
700 | 1 | a Weiderpass, Elisabeteu Office of the Director, International Agency for Research on Cancer, World Health Organization, Lyon, France4 aut |
700 | 1 | a Murphy, Neilu Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France4 aut |
700 | 1 | a Gunter, Marc J.u Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France4 aut |
700 | 1 | a Lacey, Benu Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom4 aut |
700 | 1 | a Allen, Naomi E.u Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom4 aut |
700 | 1 | a Dossus, Laureu Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France4 aut |
710 | 2 | a Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, Franceb Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom4 org |
773 | 0 | t Cancer Epidemiology, Biomarkers and Preventiond : American Association for Cancer Researchg 31:9, s. 1839-1848q 31:9<1839-1848x 1055-9965x 1538-7755 |
856 | 4 | u https://doi.org/10.1158/1055-9965.EPI-21-1176y Fulltext |
856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:1700193/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-199386 |
856 | 4 8 | u https://doi.org/10.1158/1055-9965.EPI-21-1176 |
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