Sökning: onr:"swepub:oai:DiVA.org:umu-200995" >
Site-selected thion...
Site-selected thionated benzothioxanthene chromophores as heavy-atom-free small-molecule photosensitizers for photodynamic therapy
-
- Deiana, Marco (författare)
- Umeå universitet,Institutionen för medicinsk kemi och biofysik
-
- Josse, Pierre (författare)
- Univ Angers, CNRS, MOLTECH-ANJOU, SFR MATRIX, Angers, France
-
- Dalinot, Clément (författare)
- Univ Angers, CNRS, MOLTECH-ANJOU, SFR MATRIX, Angers, France
-
visa fler...
-
- Osmolovskyi, Artem (författare)
- Univ Angers, CNRS, MOLTECH-ANJOU, SFR MATRIX, Angers, France
-
- Marqués, Pablo Simón (författare)
- Univ Angers, CNRS, MOLTECH-ANJOU, SFR MATRIX, Angers, France
-
- Castán, José María Andrés (författare)
- Univ Angers, CNRS, MOLTECH-ANJOU, SFR MATRIX, Angers, France
-
- Abad Galán, Laura (författare)
- Univ Lyon, ENS de Lyon, CNRS UMR 5182, Université Claude Bernard Lyon 1, Lyon, France
-
- Allain, Magali (författare)
- Univ Angers, CNRS, MOLTECH-ANJOU, SFR MATRIX, Angers, France
-
- Khrouz, Lhoussain (författare)
- Univ Lyon, ENS de Lyon, CNRS UMR 5182, Université Claude Bernard Lyon 1, Lyon, France
-
- Maury, Olivier (författare)
- Univ Lyon, ENS de Lyon, CNRS UMR 5182, Université Claude Bernard Lyon 1, Lyon, France
-
- Le Bahers, Tangui (författare)
- Univ Lyon, ENS de Lyon, CNRS UMR 5182, Université Claude Bernard Lyon 1, Lyon, France
-
- Blanchard, Philippe (författare)
- Univ Angers, CNRS, MOLTECH-ANJOU, SFR MATRIX, Angers, France
-
- Dabos-Seignon, Sylvie (författare)
- Univ Angers, CNRS, MOLTECH-ANJOU, SFR MATRIX, Angers, France
-
- Monnereau, Cyrille (författare)
- Univ Lyon, ENS de Lyon, CNRS UMR 5182, Université Claude Bernard Lyon 1, Lyon, France
-
- Sabouri, Nasim (författare)
- Umeå universitet,Institutionen för medicinsk kemi och biofysik
-
- Cabanetos, Clément (författare)
- Univ Angers, CNRS, MOLTECH-ANJOU, SFR MATRIX, Angers, France; IRL CNRS 2002, 2BFUEL, CNRS -Yonsei University, Seoul, South Korea
-
visa färre...
-
(creator_code:org_t)
- 2022-10-31
- 2022
- Engelska.
-
Ingår i: Communications Chemistry. - : Springer Nature. - 2399-3669. ; 5
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://umu.diva-por... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Photodynamic therapy is a clinically approved anticancer modality that employs a light-activated agent (photosensitizer) to generate cytotoxic reactive oxygen species (ROS). There is therefore a growing interest for developing innovative photosensitizing agents with enhanced phototherapeutic performances. Herein, we report on a rational design synthetic procedure that converts the ultrabright benzothioxanthene imide (BTI) dye into three heavy-atom-free thionated compounds featuring close-to-unit singlet oxygen quantum yields. In contrast to the BTI, these thionated analogs display an almost fully quenched fluorescence emission, in agreement with the formation of highly populated triplet states. Indeed, the sequential thionation on the BTI scaffold induces torsion of its skeleton reducing the singlet-triplet energy gaps and enhancing the spin-orbit coupling. These potential PSs show potent cancer-cell ablation under light irradiation while remaining non-toxic under dark condition owing to a photo-cytotoxic mechanism that we believe simultaneously involves singlet oxygen and superoxide species, which could be both characterized in vitro. Our study demonstrates that this simple site-selected thionated platform is an effective strategy to convert conventional carbonyl-containing fluorophores into phototherapeutic agents for anticancer PDT.
Ämnesord
- NATURVETENSKAP -- Biologi -- Biofysik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biophysics (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Deiana, Marco
-
Josse, Pierre
-
Dalinot, Clément
-
Osmolovskyi, Art ...
-
Marqués, Pablo S ...
-
Castán, José Mar ...
-
visa fler...
-
Abad Galán, Laur ...
-
Allain, Magali
-
Khrouz, Lhoussai ...
-
Maury, Olivier
-
Le Bahers, Tangu ...
-
Blanchard, Phili ...
-
Dabos-Seignon, S ...
-
Monnereau, Cyril ...
-
Sabouri, Nasim
-
Cabanetos, Cléme ...
-
visa färre...
- Om ämnet
-
- NATURVETENSKAP
-
NATURVETENSKAP
-
och Biologi
-
och Biofysik
- Artiklar i publikationen
-
Communications C ...
- Av lärosätet
-
Umeå universitet