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FältnamnIndikatorerMetadata
00025556naa a2201393 4500
001oai:DiVA.org:umu-201222
003SwePub
008221214s2022 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:151145920
024a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-2012222 URI
024a https://doi.org/10.1038/s41588-022-01213-w2 DOI
024a http://kipublications.ki.se/Default.aspx?queryparsed=id:1511459202 URI
040 a (SwePub)umud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
100a Ishigaki, Kazuyoshiu Center for Data Sciences, Brigham and Women’s Hospital and Harvard Medical School, MA, Boston, United States; Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, MA, Boston, United States; Laboratory for Human Immunogenetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan4 aut
2451 0a Multi-ancestry genome-wide association analyses identify novel genetic mechanisms in rheumatoid arthritis
264 c 2022-11-04
264 1b Springer Nature,c 2022
338 a print2 rdacarrier
520 a Rheumatoid arthritis (RA) is a highly heritable complex disease with unknown etiology. Multi-ancestry genetic research of RA promises to improve power to detect genetic signals, fine-mapping resolution and performances of polygenic risk scores (PRS). Here, we present a large-scale genome-wide association study (GWAS) of RA, which includes 276,020 samples from five ancestral groups. We conducted a multi-ancestry meta-analysis and identified 124 loci (P < 5 × 10−8), of which 34 are novel. Candidate genes at the novel loci suggest essential roles of the immune system (for example, TNIP2 and TNFRSF11A) and joint tissues (for example, WISP1) in RA etiology. Multi-ancestry fine-mapping identified putatively causal variants with biological insights (for example, LEF1). Moreover, PRS based on multi-ancestry GWAS outperformed PRS based on single-ancestry GWAS and had comparable performance between populations of European and East Asian ancestries. Our study provides several insights into the etiology of RA and improves the genetic predictability of RA.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
700a Sakaue, Saoriu Center for Data Sciences, Brigham and Women’s Hospital and Harvard Medical School, MA, Boston, United States; Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, MA, Boston, United States; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, MA, Cambridge, United States4 aut
700a Terao, Chikashiu Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; Clinical Research Center, Shizuoka General Hospital, Shizuoka, Japan; The Department of Applied Genetics, The School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan4 aut
700a Luo, Yangu Center for Data Sciences, Brigham and Women’s Hospital and Harvard Medical School, MA, Boston, United States; Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, MA, Boston, United States; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, MA, Cambridge, United States; Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, MA, Boston, United States; Department of Biomedical Informatics, Harvard Medical School, MA, Boston, United States4 aut
700a Sonehara, Kyutou Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan; Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Japan4 aut
700a Yamaguchi, Kensukeu Department of Genomic Function and Diversity, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan; Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan4 aut
700a Amariuta, Tiffanyu Center for Data Sciences, Brigham and Women’s Hospital and Harvard Medical School, MA, Boston, United States; Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, MA, Boston, United States; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, MA, Cambridge, United States; Department of Biomedical Informatics, Harvard Medical School, MA, Boston, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States; Halıcıoğlu Data Science Institute, University of California San Diego, La Jolla, CA, United States; Department of Medicine, University of California San Diego, La Jolla, CA, United States4 aut
700a Too, Chun Laiu Immunogenetics Unit, Allergy and Immunology Research Center, Institute for Medical Research, National Institutes of Health Complex, Ministry of Health, Kuala Lumpur, Malaysia; Department of Medicine, Division of Rheumatology, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden4 aut
700a Laufer, Vincent A.u Karolinska Institutet4 aut
700a Scott, Ian C.u Haywood Academic Rheumatology Centre, Haywood Hospital, Midlands Partnership NHS Foundation Trust, Burslem, United Kingdom; Primary Care Centre Versus Arthritis, School of Medicine, Keele University, Keele, United Kingdom4 aut
700a Viatte, Sebastienu Centre for Genetics and Genomics Versus Arthritis, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom; Lydia Becker Institute of Immunology and Inflammation, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom; NIHR Manchester Biomedical Research Centre, Manchester University Foundation Trust, Manchester, United Kingdom4 aut
700a Takahashi, Meikou Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan4 aut
700a Ohmura, Koichirou Department of Rheumatology and Clinical immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan4 aut
700a Murasawa, Akirau Department of Rheumatology, Niigata Rheumatic Center, Niigata, Japan4 aut
700a Hashimoto, Motomuu Department of Advanced Medicine for Rheumatic Diseases, Kyoto University Graduate School of Medicine, Kyoto, Japan; Department of Clinical Immunology, Graduate School of Medicine, Osaka City University, Osaka, Japan4 aut
700a Ito, Hiromuu Department of Advanced Medicine for Rheumatic Diseases, Kyoto University Graduate School of Medicine, Kyoto, Japan; Department of Orthopaedic Surgery, Kurashiki Central Hospital, Kurashiki, Japan4 aut
700a Hammoudeh, Mohammedu Rheumatology Division, Department of Internal Medicine, Hamad Medical Corporation, Doha, Qatar4 aut
700a Emadi, Samar Alu Rheumatology Division, Department of Internal Medicine, Hamad Medical Corporation, Doha, Qatar4 aut
700a Masri, Basel K.u Department of Internal Medicine, Jordan Hospital, Amman, Jordan4 aut
700a Halabi, Husseinu Section of Rheumatology, Department of Internal Medicine, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia4 aut
700a Badsha, Humeirau Dr. Humeira Badsha Medical Center, Emirates Hospital, Dubai, United Arab Emirates4 aut
700a Uthman, Imad W.u Department of Rheumatology, American University of Beirut, Beirut, Lebanon4 aut
700a Wu, Xinu Department of Rheumatology and Immunology, Shanghai Changzeng Hospital, The Second Military Medical University, Shanghai, China4 aut
700a Lin, Liu Karolinska Institutet4 aut
700a Li, Tingu Department of Rheumatology and Immunology, Shanghai Changzeng Hospital, The Second Military Medical University, Shanghai, China4 aut
700a Plant, Darrenu Centre for Genetics and Genomics Versus Arthritis, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom4 aut
700a Barton, Anneu Centre for Genetics and Genomics Versus Arthritis, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom; NIHR Manchester Biomedical Research Centre, Manchester University Foundation Trust, Manchester, United Kingdom4 aut
700a Orozco, Giselau Centre for Genetics and Genomics Versus Arthritis, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom; NIHR Manchester Biomedical Research Centre, Manchester University Foundation Trust, Manchester, United Kingdom4 aut
700a Verstappen, Suzanne M. M.u NIHR Manchester Biomedical Research Centre, Manchester University Foundation Trust, Manchester, United Kingdom; Centre for Epidemiology Versus Arthritis, Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, The University of Manchester, Manchester, United Kingdom4 aut
700a Bowes, Johnu Centre for Genetics and Genomics Versus Arthritis, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom; NIHR Manchester Biomedical Research Centre, Manchester University Foundation Trust, Manchester, United Kingdom4 aut
700a MacGregor, Alexander J.u Norwich Medical School, University of East Anglia, Norwich, United Kingdom4 aut
700a Honda, Suguruu Institute of Rheumatology, Tokyo Women’s Medical University Hospital, Tokyo, Japan; Department of Rheumatology, Tokyo Women’s Medical University School of Medicine, Tokyo, Japan4 aut
700a Koido, Masaruu Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan4 aut
700a Tomizuka, Koheiu Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan4 aut
700a Kamatani, Yoichirou Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; Laboratory of Complex Trait Genomics, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan4 aut
700a Tanaka, Hiroakiu The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health Japan, Kitakyushu, Japan4 aut
700a Tanaka, Eiichiu Institute of Rheumatology, Tokyo Women’s Medical University Hospital, Tokyo, Japan; Department of Rheumatology, Tokyo Women’s Medical University School of Medicine, Tokyo, Japan4 aut
700a Suzuki, Akariu Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan4 aut
700a Maeda, Yuichiu Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Japan; Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Japan; Department of Immunopathology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, Japan4 aut
700a Yamamoto, Kenichiu Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan; Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, Japan; Department of Pediatrics, Osaka University Graduate School of Medicine, Suita, Japan4 aut
700a Miyawaki, Satoruu Department of Neurosurgery, Faculty of Medicine, the University of Tokyo, Tokyo, Japan4 aut
700a Xie, Gangu Lunenfeld-Tanenbaum Research Institute, ON, Toronto, Canada4 aut
700a Zhang, Jinyiu Lunenfeld-Tanenbaum Research Institute, ON, Toronto, Canada; Department of Medicine, University of Toronto, ON, Toronto, Canada4 aut
700a Amos, Christopher I.u Baylor College of Medicine, TX, Houston, United States4 aut
700a Keystone, Edwardu The University of Toronto, ON, Toronto, Canada4 aut
700a Wolbink, Gertjanu Department of Rheumatology, Amsterdam Rheumatology and Immunology Center (ARC), Reade, Amsterdam, Netherlands4 aut
700a van der Horst-Bruinsma, Ireneu Department of Rheumatology & Clinical Immunology/ARC, Amsterdam Institute for Infection and Immunity, Amsterdam UMC location Vrije Universiteit, Amsterdam, Netherlands4 aut
700a Cui, Jingu Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, MA, Boston, United States4 aut
700a Liao, Katherine P.u Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, MA, Boston, United States; Department of Biomedical Informatics, Harvard Medical School, MA, Boston, United States; Massachusetts Veterans Epidemiology Research and Information Center, VA Boston Healthcare System, MA, Boston, United States4 aut
700a Carroll, Robert J.u Department of Biomedical Informatics, Vanderbilt University School of Medicine, TN, Nashville, United States4 aut
700a Lee, Hye-Soonu Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea; Hanyang University Institute for Rheumatology Research, Seoul, South Korea4 aut
700a Bang, So-Youngu Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea; Hanyang University Institute for Rheumatology Research, Seoul, South Korea4 aut
700a Siminovitch, Katherine A.u Lunenfeld-Tanenbaum Research Institute, ON, Toronto, Canada; Departments of Medicine and Immunology, University of Toronto, ON, Toronto, Canada4 aut
700a de Vries, Nieku Department of Rheumatology & Clinical Immunology/ARC, Amsterdam Institute for Infection and Immunity, Amsterdam UMC location AMC/University of Amsterdam, Amsterdam, Netherlands4 aut
700a Alfredsson, Larsu Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden4 aut
700a Rantapää-Dahlqvist, Solbrittu Umeå universitet,Reumatologi4 aut0 (Swepub:umu)sora0001
700a Karlson, Elizabeth W.u Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, MA, Boston, United States4 aut
700a Bae, Sang-Cheolu Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea; Hanyang University Institute for Rheumatology Research, Seoul, South Korea4 aut
700a Kimberly, Robert P.u Center for Clinical and Translational Science, Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, AL, Birmingham, United States4 aut
700a Edberg, Jeffrey C.u Center for Clinical and Translational Science, Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, AL, Birmingham, United States4 aut
700a Mariette, Xavieru Department of Rheumatology, Université Paris-Saclay, Assistance Pubique - Hôpitaux de Paris, Hôpital Bicêtre, INSERM UMR1184, Le Kremlin Bicêtre, France4 aut
700a Huizinga, Tomu Leiden University Medical Center, Leiden, Netherlands4 aut
700a Dieudé, Philippeu University of Paris Cité, Inserm, PHERE, F-75018, Paris, France; Department of Rheumatology, Hôpital Bichat, APHP, Paris, France4 aut
700a Schneider, Matthiasu Department of Rheumatology & Hiller Research Unit Rheumatology, UKD, Heinrich-Heine University, Düsseldorf, Germany4 aut
700a Kerick, Martinu Institute of Parasitology and Biomedicine Lopez-Neyra, CSIC, Granada, Spain4 aut
700a Denny, Joshua C.u Department of Biomedical Informatics, Vanderbilt University School of Medicine, TN, Nashville, United States; All of Us Research Program, Office of the Director, National Institutes of Health, MD, Bethesda, United States; Department of Medicine, Vanderbilt University School of Medicine, TN, Nashville, United States4 aut
700a Matsuda, Koichiu Laboratory of Genome Technology, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan; Laboratory of Clinical Genome Sequencing, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan4 aut
700a Matsuo, Keitarou Division of Cancer Epidemiology and Prevention, Department of Preventive Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan; Department of Cancer Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan4 aut
700a Mimori, Tsuneyou Department of Rheumatology and Clinical immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan4 aut
700a Matsuda, Fumihikou Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan4 aut
700a Fujio, Keishiu Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan4 aut
700a Tanaka, Yoshiyau The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health Japan, Kitakyushu, Japan4 aut
700a Kumanogoh, Atsushiu Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Japan; Centre for Genetics and Genomics Versus Arthritis, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom; Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Japan; Department of Immunopathology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, Japan4 aut
700a Traylor, Matthewu Department of Medical & Molecular Genetics, King’s College London, London, United Kingdom; Department of Genetics, Novo Nordisk Research Centre Oxford, Oxford, United Kingdom; Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom4 aut
700a Lewis, Cathryn M.u Department of Medical & Molecular Genetics, King’s College London, London, United Kingdom; Social, Genetic and Developmental Psychiatry Centre, King’s College London, London, United Kingdom4 aut
700a Eyre, Stephenu Centre for Genetics and Genomics Versus Arthritis, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom; NIHR Manchester Biomedical Research Centre, Manchester University Foundation Trust, Manchester, United Kingdom4 aut
700a Xu, Hujiu Department of Rheumatology and Immunology, Shanghai Changzeng Hospital, The Second Military Medical University, Shanghai, China; School of Clinical Medicine Tsinghua University, Beijing, China; Peking-Tsinghua Center for Life Sciences, Tsinghua University, Beijing, China4 aut
700a Saxena, Richau Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, MA, Cambridge, United States4 aut
700a Arayssi, Thurayyau Department of Internal Medicine, Weill Cornell Medicine-Qatar, Education City, Doha, Qatar4 aut
700a Kochi, Yutau Department of Genomic Function and Diversity, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan; Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan4 aut
700a Ikari, Katsunoriu Institute of Rheumatology, Tokyo Women’s Medical University Hospital, Tokyo, Japan; Department of Orthopedic Surgery, Tokyo Women’s Medical University School of Medicine, Tokyo, Japan; Division of Multidisciplinary Management of Rheumatic Diseases, Tokyo Women’s Medical University, Tokyo, Japan4 aut
700a Harigai, Masayoshiu Institute of Rheumatology, Tokyo Women’s Medical University Hospital, Tokyo, Japan; Division of Rheumatology, Department of Internal Medicine, Tokyo Women’s Medical University School of Medicine, Tokyo, Japan4 aut
700a Gregersen, Peter K.u Robert S. Boas Center for Genomics and Human Genetics, Feinstein Institutes for Medical Research, Northwell Health, NY, Manhasset, United States4 aut
700a Yamamoto, Kazuhikou Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan4 aut
700a Louis Bridges, S.u Department of Medicine, Hospital for Special Surgery, NY, New York, United States; Division of Rheumatology, Weill Cornell Medicine, NY, New York, United States4 aut
700a Padyukov, Leonidu Department of Medicine, Division of Rheumatology, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden4 aut
700a Martin, Javieru Institute of Parasitology and Biomedicine Lopez-Neyra, CSIC, Granada, Spain4 aut
700a Klareskog, Larsu Department of Medicine, Division of Rheumatology, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden4 aut
700a Okada, Yukinoriu Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan; Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Japan; Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, Japan; Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; Center for Infectious Disease Education and Research (CiDER), Osaka University, Suita, Japan; Department of Genome Informatics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan4 aut
700a Raychaudhuri, Soumyau Center for Data Sciences, Brigham and Women’s Hospital and Harvard Medical School, MA, Boston, United States; Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, MA, Boston, United States; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, MA, Cambridge, United States; Division of Rheumatology, Inflammation, and Immunity, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, MA, Boston, United States; Department of Biomedical Informatics, Harvard Medical School, MA, Boston, United States; Centre for Genetics and Genomics Versus Arthritis, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom4 aut
710a Center for Data Sciences, Brigham and Women’s Hospital and Harvard Medical School, MA, Boston, United States; Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, MA, Boston, United States; Laboratory for Human Immunogenetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japanb Center for Data Sciences, Brigham and Women’s Hospital and Harvard Medical School, MA, Boston, United States; Division of Genetics, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, MA, Boston, United States; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, MA, Cambridge, United States4 org
773t Nature Geneticsd : Springer Natureg 54:11, s. 1640-1651q 54:11<1640-1651x 1061-4036x 1546-1718
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-201222
8564 8u https://doi.org/10.1038/s41588-022-01213-w
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:151145920

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