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Sökning: onr:"swepub:oai:DiVA.org:umu-201225" > A retrospective ana...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004951naa a2200541 4500
001oai:DiVA.org:umu-201225
003SwePub
008221205s2022 | |||||||||||000 ||eng|
009oai:DiVA.org:liu-190220
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-2012252 URI
0247 a https://doi.org/10.3390/jpm121117692 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1902202 URI
040 a (SwePub)umud (SwePub)liu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Eriksson, Victoriau Umeå universitet,Urologi och andrologi,Umea Univ, Sweden4 aut0 (Swepub:umu)vier0022
2451 0a A retrospective analysis of the de ritis ratio in muscle invasive bladder cancer, with focus on tumor response and long-term survival in patients receiving neoadjuvant chemotherapy and in chemo naïve cystectomy patients :b a study of a clinical multicentre database
264 c 2022-10-27
264 1b MDPI,c 2022
338 a electronic2 rdacarrier
500 a Funding Agencies|Swedish Research Council [Bas-ALF/VLL RV-848051]
520 a Background: A high pre-treatment De Ritis ratio, the aspartate transaminase/alanine aminotransferase ratio, has been suggested to be of prognostic value for mortality in muscle-invasive bladder cancer (MIBC). Our purpose was to evaluate if a high ratio was associated with mortality and downstaging. Methods: A total of 347 Swedish patients with clinically staged T2-T4aN0M0, with administered neoadjuvant chemotherapy (NAC) or eligible for NAC and undergoing radical cystectomy (RC) 2009–2021, were retrospectively evaluated with a low ratio < 1.3 vs. high ratio > 1.3, by Log Rank test, Cox regression and Mann–Whitney U-test (MWU), SPSS 27. Results: Patients with a high ratio had a decrease of up to 3 years in disease-free survival (DFS), cancer-specific survival (CSS) and overall survival (OS) (p = 0.009, p = 0.004 and p = 0.009) and 5 years in CSS and OS (p = 0.019 and p = 0.046). A high ratio was associated with increased risk of mortality, highest in DFS (HR, 1.909; 95% CI, 1.265–2.880; p = 0.002). No significant relationship between downstaging and a high ratio existed (p = 0.564 MWU). Conclusion: A high pre-treatment De Ritis ratio is on a population level, associated with increased mortality post-RC in endpoints DFS, CSS and OS. Associations decrease over time and require further investigations to determine how strong the associations are as meaningful prognostic markers for long-term mortality in MIBC. The ratio is not suitable for downstaging-prediction.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Urologi och njurmedicin0 (SwePub)302142 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Urology and Nephrology0 (SwePub)302142 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653 a clinical decision rules
653 a cystectomy
653 a neoadjuvant therapy
653 a prognosis
653 a urinary bladder neoplasms
7001 a Holmkvist, Oscaru Umeå universitet,Urologi och andrologi,Umea Univ, Sweden4 aut
7001 a Huge, Ylvau Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Urologiska kliniken i Östergötland4 aut0 (Swepub:liu)ylvhu61
7001 a Johansson, Markusu Department of Surgery, Division of Urology, Sundsvall-Härnösand County Hospital, Sundsvall, Sweden,Sundsvall Harnosand Cty Hosp, Sweden4 aut
7001 a Alamdari, Farhoodu Department of Urology, Västmanland Hospital, Västerås, Sweden,Vastmanland Hosp, Sweden4 aut
7001 a Svensson, Johan,d 1978-u Umeå universitet,Statistik,Umea Univ, Sweden4 aut0 (Swepub:umu)josv0027
7001 a Aljabery, Firasu Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Urologiska kliniken i Östergötland4 aut0 (Swepub:liu)firab05
7001 a Sherif, Amiru Umeå universitet,Urologi och andrologi,Umea Univ, Sweden4 aut0 (Swepub:umu)amsh0008
7102 a Umeå universitetb Urologi och andrologi4 org
7730 t Journal of Personalized Medicined : MDPIg 12:11q 12:11x 2075-4426
8564 u https://doi.org/10.3390/jpm12111769y Fulltext
8564 u https://umu.diva-portal.org/smash/get/diva2:1716118/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://liu.diva-portal.org/smash/get/diva2:1714604/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-201225
8564 8u https://doi.org/10.3390/jpm12111769
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-190220

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