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Expression pattern ...
Expression pattern of the orphan nuclear receptor, nurr1, in the developing mouse forelimb and its relationship to limb skeletogenesis and osteogenesis
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- Ahmed, Heba A. (författare)
- Department of Biological and Geological Sciences, University of Alexandria, Egypt
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- Ibrahim, Lidia L. (författare)
- Department of Biological and Geological Sciences, University of Alexandria, Egypt
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- El Mekkawy, Desouki A. (författare)
- Department of Zoology, University of Alexandria, Egypt
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- El Wakil, Abeer (författare)
- Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet),Department of Biological and Geological Sciences, University of Alexandria, Egypt
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(creator_code:org_t)
- Science Publications, 2015
- 2015
- Engelska.
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Ingår i: OnLine Journal of Biological Sciences. - : Science Publications. - 1608-4217. ; 15:3, s. 162-169
- Relaterad länk:
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https://doi.org/10.3...
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https://umu.diva-por... (primary) (Raw object)
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- The NR4A orphan nuclear receptor, Nurr1, has been shown to regulate the expression of osteoblastic genes and osteoblastic differentiation. However, the expression profile of Nurr1 in the developing mouse forelimb and its relationship to skeletogenesis has not, to the best of our knowledge, been previously analyzed. In this study, the relationship between Nurr1 expression pattern, skeletogenesis and osteogenesis in the developing mouse forelimb was investigated. The expression level of Nurr1 during development was also quantified by real time-polymerase chain reaction. Our results revealed that Nurr1 is expressed in the mesenchyme cells that will form the skeleton. Nurr1 is aabundantly expressed in the primary ossification centers of the forelimb skeletal elements and its expression level is gradually increased during limb development, particularly, at the onset of ossification. Collectively, these data suggested that Nurr1 plays an important role in skeletogenesis and patterning of the developing mouse forelimb.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- Limb patterning
- Nuclear orphan receptors
- Nurr1
- Osteogenesis
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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