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Genetically Determi...
Genetically Determined Reproductive Aging and Coronary Heart Disease : A Bidirectional 2-sample Mendelian Randomization
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- Dam, Veerle (författare)
- Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands; Netherlands Heart Institute, Utrecht, Netherlands,Interuniversity Cardiology Institute of the Netherlands
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- Onland-Moret, N. Charlotte (författare)
- Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands
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- Burgess, Stephen (författare)
- MRC Biostatistics Unit, University of Cambridge, Cambridge, United Kingdom; MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom; Homerton College, Cambridge, United Kingdom
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- Chirlaque, Maria-Dolores (författare)
- Department of Epidemiology, Regional Health Authority, IMIB-Arrixaca, Murcia University, Murcia, Spain
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- Peters, Sanne A. E (författare)
- Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands; The George Institute for Global Health, Imperial College London, London, United Kingdom
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- Schuit, Ewoud (författare)
- Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands
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- Tikk, Kaja (författare)
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Centre (DKFZ), Heidelberg, Germany; German Cancer Consortium, DKFZ, Heidelberg, Germany
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- Weiderpass, Elisabete (författare)
- International Agency for Research on Cancer, World Health Organization, Lyon, France
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- Oliver-Williams, Clare (författare)
- MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom; Homerton College, Cambridge, United Kingdom
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- Wood, Angela M (författare)
- MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
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- Tjønneland, Anne (författare)
- Danish Cancer Society Research Center, Copenhagen, Denmark; Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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- Dahm, Christina C (författare)
- Department of Public Health, Aarhus University, Aarhus, Denmark
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- Overvad, Kim (författare)
- Department of Public Health, Aarhus University, Aarhus, Denmark; Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark
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- Boutron-Ruault, Marie-Christine (författare)
- INSERM, Centre for Research in Epidemiology and Population Health, U1018, Nutrition, Hormones, and Women's Health Team, Institut Gustave Roussy, Villejuif, France
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- Schulze, Matthias B (författare)
- Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbruecke, Nuthetal, Germany; Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany
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- Trichopoulou, Antonia (författare)
- Hellenic Health Foundation, Athens, Greece; WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece
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- Ferrari, Pietro (författare)
- International Agency for Research on Cancer, World Health Organization, Lyon, France
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- Masala, Giovanna (författare)
- Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network - ISPRO, Florence, Italy
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- Krogh, Vittorio (författare)
- Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
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- Tumino, Rosario (författare)
- Cancer Registry and Histopathology Department, "Civic - M.P. Arezzo" hospital, ASP Ragusa, Ragusa, Italy
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- Matullo, Giuseppe (författare)
- Department of Medical Sciences, University of Torino, Torino, Italy; Italian Institute for Genomic Medicine–IIGM/HuGeF, Torino, Italy
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- Panico, Salvatore (författare)
- Dipartimento di medicina clinica e chirurgia, Federico II University, Naples, Italy
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- Boer, Jolanda M. A (författare)
- National Institute for Public Health and the Environment, Bilthoven, Netherlands
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- Verschuren, W. M. Monique (författare)
- Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands; National Institute for Public Health and the Environment, Bilthoven, Netherlands
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- Waaseth, Marit (författare)
- Department of Pharmacy, Faculty of Health Sciences, UiT the Arctic University of Norway, Tromsø, Norway
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- PCrossed D sign©rez, Maria JosCrossed D sign© Sánchez (författare)
- Escuela Andaluza de Salud Pública. Instituto de Investigación Biosanitaria ibs.GRANADA, Universidad de Granada, Granada, Spain; CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
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- Amiano, Pilar (författare)
- CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Public Health Division of Gipuzkoa, Biodonostia Research Institute, San Sebastian, Spain
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- Imaz, Liher (författare)
- CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Public Health Division of Gipuzkoa, Biodonostia Research Institute, San Sebastian, Spain
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- Moreno-Iribas, Conchi (författare)
- Instituto de Salud Pública de Navarra, IdiSNA, Navarre Institute for Health Research, REDISSEC, Pamplona, Spain
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- Melander, O. (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
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- Harlid, Sophia, 1978- (författare)
- Umeå universitet,Onkologi
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- Nordendahl, Maria (författare)
- Umeå universitet,Onkologi,Allmänmedicin
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- Wennberg, Patrik, 1972- (författare)
- Umeå universitet,Allmänmedicin
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- Key, Timothy J (författare)
- Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
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- Riboli, Elio (författare)
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
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- Santiuste, Carmen (författare)
- CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Department of Epidemiology, Murcia Regional Health Authority, IMIB-Arrixaca, Murcia, Spain
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- Kaaks, Rudolf (författare)
- Division of Cancer Epidemiology, DKFZ, Foundation under Public Law, Heidelberg, Germany
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- Katzke, Verena (författare)
- Division of Cancer Epidemiology, DKFZ, Foundation under Public Law, Heidelberg, Germany
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- Langenberg, Claudia (författare)
- MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom
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- Wareham, Nicholas J (författare)
- MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom
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- Schunkert, Heribert (författare)
- Deutsches Herzzentrum München, Technische Universität München, Munich, Germany; DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany
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- Erdmann, Jeanette (författare)
- Institute for Cardiogenetics, University of Lübeck, Lübeck, Germany
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- Willenborg, Christina (författare)
- Institute for Cardiogenetics, University of Lübeck, Lübeck, Germany
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- Hengstenberg, Christian (författare)
- Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Vienna, Austria
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- Kleber, Marcus E (författare)
- Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
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- Delgado, Graciela (författare)
- Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
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- März, Winfried (författare)
- Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; Synlab Academy, Synlab Holding Deutschland GmbH, Mannheim, Germany; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria
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- Kanoni, Stavroula (författare)
- William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
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- Dedoussis, George (författare)
- Department of Nutrition-Dietetics/Harokopio University, Athens, Greece
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- Deloukas, Panos (författare)
- William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom; Centre for Genomic Health, Queen Mary University of London, London, United Kingdom; Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders, King Abdulaziz University, Jeddah, Saudi Arabia
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- Nikpay, Majid (författare)
- Ruddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, ON, Ottawa, Canada
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- Mcpherson, Ruth (författare)
- Ruddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, ON, Ottawa, Canada
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- Scholz, Markus (författare)
- Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany; LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany
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- Teren, Andrej (författare)
- LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany; Heart Center Leipzig, Leipzig, Germany
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- Butterworth, Adam S (författare)
- MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
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- Van Der Schouw, Yvonne T (författare)
- Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands
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(creator_code:org_t)
- 2022-03-20
- 2022
- Engelska.
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Ingår i: Journal of Clinical Endocrinology and Metabolism. - : The Endocrine Society. - 0021-972X .- 1945-7197. ; 107:7, s. E2952-E2961
- Relaterad länk:
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https://doi.org/10.1...
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Background: Accelerated reproductive aging, in women indicated by early natural menopause, is associated with increased coronary heart disease (CHD) risk in observational studies. Conversely, an adverse CHD risk profile has been suggested to accelerate menopause. Objectives: To study the direction and evidence for causality of the relationship between reproductive aging and (non-)fatal CHD and CHD risk factors in a bidirectional Mendelian randomization (MR) approach, using age at natural menopause (ANM) genetic variants as a measure for genetically determined reproductive aging in women. We also studied the association of these variants with CHD risk (factors) in men. Design: Two-sample MR, using both cohort data as well as summary statistics, with 4 methods: simple and weighted median-based, standard inverse-variance weighted (IVW) regression, and MR-Egger regression. Participants: Data from EPIC-CVD and summary statistics from UK Biobank and publicly available genome-wide association studies were pooled for the different analyses. Main Outcome Measures: CHD, CHD risk factors, and ANM. Results: Across different methods of MR, no association was found between genetically determined reproductive aging and CHD risk in women (relative risk estimateIVW = 0.99; 95% confidence interval (CI), 0.97-1.01), or any of the CHD risk factors. Similarly, no associations were found in men. Neither did the reversed analyses show evidence for an association between CHD (risk factors) and reproductive aging. Conclusion: Genetically determined reproductive aging is not causally associated with CHD risk (factors) in women, nor were the genetic variants associated in men. We found no evidence for a reverse association in a combined sample of women and men.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- coronary heart disease
- Mendelian Randomization
- reproductive aging
- risk factors
- coronary heart disease
- Mendelian Randomization
- reproductive aging
- risk factors
- aging
- coronary artery disease
- female
- genetics
- genome-wide association study
- human
- male
- Mendelian randomization analysis
- procedures
- single nucleotide polymorphism
- Aging
- Coronary Disease
- Female
- Genome-Wide Association Study
- Humans
- Male
- Mendelian Randomization Analysis
- Polymorphism, Single Nucleotide
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Dam, Veerle
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Onland-Moret, N. ...
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Burgess, Stephen
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Chirlaque, Maria ...
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Peters, Sanne A. ...
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Schuit, Ewoud
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visa fler...
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Tikk, Kaja
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Weiderpass, Elis ...
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Oliver-Williams, ...
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Wood, Angela M
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Tjønneland, Anne
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Dahm, Christina ...
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Overvad, Kim
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Boutron-Ruault, ...
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Schulze, Matthia ...
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Trichopoulou, An ...
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Ferrari, Pietro
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Masala, Giovanna
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Krogh, Vittorio
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Tumino, Rosario
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Matullo, Giusepp ...
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Panico, Salvator ...
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Boer, Jolanda M. ...
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Verschuren, W. M ...
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Waaseth, Marit
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PCrossed D sign© ...
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Amiano, Pilar
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Imaz, Liher
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Moreno-Iribas, C ...
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Melander, O.
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Harlid, Sophia, ...
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Nordendahl, Mari ...
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Wennberg, Patrik ...
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Key, Timothy J
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Riboli, Elio
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Santiuste, Carme ...
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Kaaks, Rudolf
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Katzke, Verena
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Langenberg, Clau ...
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Wareham, Nichola ...
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Schunkert, Herib ...
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Erdmann, Jeanett ...
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Willenborg, Chri ...
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Hengstenberg, Ch ...
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Kleber, Marcus E
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Delgado, Graciel ...
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März, Winfried
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Kanoni, Stavroul ...
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Dedoussis, Georg ...
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Deloukas, Panos
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Nikpay, Majid
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Mcpherson, Ruth
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Scholz, Markus
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Teren, Andrej
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Butterworth, Ada ...
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Van Der Schouw, ...
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MEDICIN OCH HÄLS ...
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och Endokrinologi oc ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
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