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Longitudinal neurop...
Longitudinal neuropsychological trajectories in idiopathic normal pressure hydrocephalus : a population–based study
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- Lilja-Lund, Otto, 1981- (författare)
- Umeå universitet,Neurovetenskaper,Umeå Univ, Dept Clin Sci, Neurosci, Umeå, Sweden.
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- Maripuu, Martin (författare)
- Umeå universitet,Psykiatri,Umeå Univ, Dept Clin Sci, Psychiat, Umeå, Sweden.
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- Kockum, Karin (författare)
- Umeå universitet,Neurovetenskaper,Umeå Univ, Dept Clin Sci, Neurosci, Umeå, Sweden.
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- Andersson, Johanna, 1990- (författare)
- Umeå universitet,Neurovetenskaper,Umeå Univ, Dept Clin Sci, Neurosci, Umeå, Sweden.
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- Lindam, Anna, PhD, 1978- (författare)
- Umeå universitet,Institutionen för folkhälsa och klinisk medicin,Umeå Univ, Östersund Hosp, Dept Publ Hlth & Clin Med, Unit Res Educ & Dev, Umeå, Sweden.
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- Nyberg, Lars, 1966- (författare)
- Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB),Umeå centrum för funktionell hjärnavbildning (UFBI),Center for Lifespan Changes in Brain and Cognition, University of Oslo, Oslo, Norway,Umeå Univ, Dept Radiat Sci, Radiol, Umeå, Sweden.;Umeå Univ, Dept Integrat Med Biol, Umeå, Sweden.;Umeå Univ, Umeå Ctr Funct Brain Imaging, Umeå, Sweden.;Univ Oslo, Ctr Lifespan Changes Brain & Cognit, Oslo, Norway.
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- Laurell, Katarina, 1967- (författare)
- Uppsala universitet,Neurologi
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(creator_code:org_t)
- 2023-01-16
- 2023
- Engelska.
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Ingår i: BMC Geriatrics. - : BioMed Central (BMC). - 1471-2318. ; 23:1
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Background: Idiopathic normal pressure hydrocephalus (iNPH) is a progressive syndrome affecting gait, incontinence, and cognition in a significant number of older adults. Still, prospective studies on early development of symptoms are scarce.Aim: To investigate how neuropsychological functions develop before and in already diagnosed iNPH over a two-year period in a population-based material.Method: A sample of 104 participants (median [IQR] 75 [72–80] years old) from the general population underwent CT-imaging and clinical assessment at baseline and follow-up. We used the iNPH symptom scale covering four domains (Neuropsychology, Gait, Balance, Incontinence) and additional tests of executive functions. Morphological signs were rated with the iNPH Radscale. Non-parametric statistics with Bonferroni corrections and a significance-level of p < 0.05 were used.Results: Median (IQR) time to follow-up was 25 (23–26) months. Effect size (ES) for individuals who developed iNPH (n = 8) showed a large (ES r = -0.55) decline in the Gait domain and on the Radscale (ES r = -0.60), with a medium deterioration in declarative memory (ES r = -0.37). Those having iNPH at baseline (n = 12) performed worse on one executive sub-function i.e., shifting (p = 0.045).Conclusion: Besides deterioration in gait and radiology, our results suggest that a neuropsychological trajectory for those developing iNPH includes a reduction in declarative memory. Executive dysfunction was limited to those already having iNPH at baseline. These findings could suggest that memory impairments are included in the early development of iNPH.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
Nyckelord
- Ageing
- Cognition
- Cognitive development
- Idiopathic normal pressure hydrocephalus
- Life-span
- Neuropsychology
- Older adults
- Population-based
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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