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Prediagnostic serum...
Prediagnostic serum calcium concentrations and risk of colorectal cancer development in 2 large European prospective cohorts
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- Karavasiloglou, Nena (författare)
- Nutrition and Metabolism Branch, International Agency for Research on Cancer (IARC-WHO), Lyon, France; Division of Chronic Disease Epidemiology, Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland
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- Hughes, David J. (författare)
- Cancer Biology and Therapeutics Group, UCD Conway Institute, School of Biomolecular and Biomedical Science, University College Dublin, Dublin, Ireland
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- Murphy, Neil (författare)
- Nutrition and Metabolism Branch, International Agency for Research on Cancer (IARC-WHO), Lyon, France
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- Schomburg, Lutz (författare)
- Institut für Experimentelle Endokrinologie, Charité-Universitätsmedizin Berlin, Berlin, Germany
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- Sun, Qian (författare)
- Institut für Experimentelle Endokrinologie, Charité-Universitätsmedizin Berlin, Berlin, Germany
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- Seher, Vartiter (författare)
- Institut für Experimentelle Endokrinologie, Charité-Universitätsmedizin Berlin, Berlin, Germany
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- Rohrmann, Sabine (författare)
- Division of Chronic Disease Epidemiology, Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland
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- Weiderpass, Elisabete (författare)
- Office of the Director, International Agency for Research on Cancer (IARC-WHO), Lyon, France
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- Tjønneland, Anne (författare)
- Danish Cancer Society Research Center, Diet, Genes and Environment, Copenhagen, Denmark; University of Copenhagen, Department of Public Health, Copenhagen, Denmark
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- Olsen, Anja (författare)
- Danish Cancer Society Research Center, Diet, Genes and Environment, Copenhagen, Denmark; University of Århus, Department of Public Health, Århus, Denmark
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- Overvad, Kim (författare)
- University of Århus, Department of Public Health, Århus, Denmark
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- Boutron-Ruault, Marie-Christine (författare)
- CESP, Fac. de médecine - Univ. Paris-Sud, Fac. de médecine - UVSQ, INSERM, Université Paris-Saclay, Villejuif, France; Gustave Roussy, Villejuif, France
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- Mancini, Francesca Romana (författare)
- CESP, Fac. de médecine - Univ. Paris-Sud, Fac. de médecine - UVSQ, INSERM, Université Paris-Saclay, Villejuif, France; Gustave Roussy, Villejuif, France
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- Mahamat-Saleh, Yahya (författare)
- CESP, Fac. de médecine - Univ. Paris-Sud, Fac. de médecine - UVSQ, INSERM, Université Paris-Saclay, Villejuif, France; Gustave Roussy, Villejuif, France
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- Kaaks, Rudolf (författare)
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Kuhn, Tilman (författare)
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; School of Biological Sciences, Queens University of Belfast, Belfast, Northern Ireland
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- Schulze, Matthias B. (författare)
- Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany
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- Tumino, Rosario (författare)
- Hyblean Association for Epidemiology Research, Italy
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- Panico, Salvatore (författare)
- Dipartimento Di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy
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- Masala, Giovanna (författare)
- Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy
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- Pala, Valeria (författare)
- Epidemiology and Prevention Unit Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy
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- Sacerdote, Carlotta (författare)
- Unit of Cancer Epidemiology, Città della Salute e della Scienza University-Hospital, Turin, Italy
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- Derksen, Jeroen W G (författare)
- Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands
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- Skeie, Guri (författare)
- Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Arctic University of Norway, Norway
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- Hjartåker, Anette (författare)
- Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Norway
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- Lasheras, Cristina (författare)
- Department of Functional Biology, Faculty of Medicine, University of Oviedo, Asturias, Spain
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- Agudo, Antonio (författare)
- Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain
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- Sánchez, Maria-José (författare)
- Escuela Andaluza de Salud Pública (EASP), Granada, Spain; Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain; CIBER in Epidemiology and Public Health (CIBERESP), Madrid, Spain; Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain
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- Chirlaque, Maria-Dolores (författare)
- CIBER in Epidemiology and Public Health (CIBERESP), Madrid, Spain; Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia University, Spain
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- Ardanaz, Eva (författare)
- CIBER in Epidemiology and Public Health (CIBERESP), Madrid, Spain; Navarra Public Health Institute, Pamplona, Spain; IdiSNA, Navarra Institute for Health Research, Pamplona, Spain
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- Amiano, Pilar (författare)
- CIBER in Epidemiology and Public Health (CIBERESP), Madrid, Spain; Ministry of Health of the Basque Government, Sub Directorate for Public Health and Addictions of Gipuzkoa; Biodonostia Health Research Institute, Epidemiology of Chronic and Communicable Diseases Group, San Sebastián, Spain
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- van Guelpen, Bethany (författare)
- Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Onkologi
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- Gylling, Björn, 1978- (författare)
- Umeå universitet,Patologi
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- Bradbury, Kathryn E. (författare)
- National Institute for Health Innovation, University of Auckland, New Zealand
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- Papier, Keren (författare)
- Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
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- Freisling, Heinz (författare)
- Nutrition and Metabolism Branch, International Agency for Research on Cancer (IARC-WHO), Lyon, France
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- Aglago, Elom K. (författare)
- Nutrition and Metabolism Branch, International Agency for Research on Cancer (IARC-WHO), Lyon, France; Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom
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- Cross, Amanda J. (författare)
- Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom
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- Riboli, Elio (författare)
- Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom
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- Aune, Dagfinn (författare)
- Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom
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- Gunter, Marc J. (författare)
- Nutrition and Metabolism Branch, International Agency for Research on Cancer (IARC-WHO), Lyon, France
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- Jenab, Mazda (författare)
- Nutrition and Metabolism Branch, International Agency for Research on Cancer (IARC-WHO), Lyon, France
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(creator_code:org_t)
- Elsevier, 2023
- 2023
- Engelska.
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Ingår i: American Journal of Clinical Nutrition. - : Elsevier. - 0002-9165 .- 1938-3207. ; 117:1, s. 33-45
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Higher dietary calcium consumption is associated with lower colorectal cancer (CRC) risk. However, little data are available on the association between circulating calcium concentrations and CRC risk.OBJECTIVES: To explore the association between circulating calcium concentrations and CRC risk using data from 2 large European prospective cohort studies.METHODS: Conditional logistic regression models were used to calculate multivariable-adjusted ORs and 95% CIs in case-control studies nested within the European Prospective Investigation into Cancer and Nutrition (EPIC; n-cases = 947, n-controls = 947) and the UK Biobank (UK-BB; n-cases = 2759, n-controls = 12,021) cohorts.RESULTS: In EPIC, nonalbumin-adjusted total serum calcium (a proxy of free calcium) was not associated with CRC (OR: 0.94; 95% CI: 0.85, 1.03; modeled as continuous variable, per 1 mg/dL increase), colon cancer (OR: 0.93; 95% CI: 0.82, 1.05) or rectal cancer (OR: 1.01; 95% CI: 0.84, 1.20) risk in the multivariable adjusted model. In the UK-BB, serum ionized calcium (free calcium, most active form) was inversely associated with the risk of CRC (OR: 0.85; 95% CI: 0.76, 0.95; per 1 mg/dL) and colon cancer (OR: 0.78; 95% CI: 0.68, 0.90), but not rectal cancer (OR: 1.02; 95% CI: 0.83, 1.24) in multivariable adjusted models. Meta-analysis of EPIC and UK-BB CRC risk estimates showed an inverse risk association for CRC in the multivariable adjusted model (OR: 0.90; 95%CI: 0.84, 0.97). In analyses by quintiles, in both cohorts, higher levels of serum calcium were associated with reduced CRC risk (EPIC: ORQ5vs.Q1: 0.69; 95% CI: 0.47, 1.00; P-trend = 0.03; UK-BB: ORQ5vs.Q1: 0.82; 95% CI: 0.72, 0.94; P-trend < 0.01). Analyses by anatomical subsite showed an inverse cancer risk association in the colon (EPIC: ORQ5vs.Q1: 0.63, 95% CI: 0.39, 1.02; P-trend = 0.05; UK-BB: ORQ5vs.Q1: 0.75; 95% CI: 0.64, 0.88; P-trend < 0.01) but not the rectum.CONCLUSIONS: In UK-BB, higher serum ionized calcium levels were inversely associated with CRC, but the risk was restricted to the colon. Total serum calcium showed a null association in EPIC. Additional prospective studies in other populations are needed to better investigate these associations.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- cancer
- cohort
- colorectal
- risk
- serum calcium
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Karavasiloglou, ...
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Hughes, David J.
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Murphy, Neil
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Schomburg, Lutz
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Sun, Qian
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Seher, Vartiter
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visa fler...
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Rohrmann, Sabine
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Weiderpass, Elis ...
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Tjønneland, Anne
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Olsen, Anja
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Overvad, Kim
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Boutron-Ruault, ...
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Mancini, Frances ...
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Mahamat-Saleh, Y ...
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Kaaks, Rudolf
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Kuhn, Tilman
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Schulze, Matthia ...
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Tumino, Rosario
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Panico, Salvator ...
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Masala, Giovanna
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Pala, Valeria
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Sacerdote, Carlo ...
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Derksen, Jeroen ...
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Skeie, Guri
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Hjartåker, Anett ...
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Lasheras, Cristi ...
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Agudo, Antonio
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Sánchez, Maria-J ...
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Chirlaque, Maria ...
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Ardanaz, Eva
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Amiano, Pilar
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van Guelpen, Bet ...
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Gylling, Björn, ...
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Bradbury, Kathry ...
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Papier, Keren
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Freisling, Heinz
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Aglago, Elom K.
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Cross, Amanda J.
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Riboli, Elio
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Aune, Dagfinn
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Gunter, Marc J.
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Jenab, Mazda
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