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Sökning: onr:"swepub:oai:DiVA.org:umu-205643" > Circulating amino a...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00012344naa a2200937 4500
001oai:DiVA.org:umu-205643
003SwePub
008230314s2023 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-2056432 URI
0247 a https://doi.org/10.1186/s12916-023-02739-42 DOI
040 a (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Rothwell, Joseph A.u Centre for Epidemiology and Population Health (Inserm U1018), Exposome and Heredity team, Faculté de Médecine, Université Paris-Saclay, UVSQ, Gustave Roussy, Villejuif, France4 aut
2451 0a Circulating amino acid levels and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition and UK Biobank cohorts
264 c 2023-02-28
264 1b BioMed Central (BMC),c 2023
338 a electronic2 rdacarrier
520 a Background: Amino acid metabolism is dysregulated in colorectal cancer patients; however, it is not clear whether pre-diagnostic levels of amino acids are associated with subsequent risk of colorectal cancer. We investigated circulating levels of amino acids in relation to colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) and UK Biobank cohorts.Methods: Concentrations of 13-21 amino acids were determined in baseline fasting plasma or serum samples in 654 incident colorectal cancer cases and 654 matched controls in EPIC. Amino acids associated with colorectal cancer risk following adjustment for the false discovery rate (FDR) were then tested for associations in the UK Biobank, for which measurements of 9 amino acids were available in 111,323 participants, of which 1221 were incident colorectal cancer cases.Results: Histidine levels were inversely associated with colorectal cancer risk in EPIC (odds ratio [OR] 0.80 per standard deviation [SD], 95% confidence interval [CI] 0.69–0.92, FDR P-value=0.03) and in UK Biobank (HR 0.93 per SD, 95% CI 0.87–0.99, P-value=0.03). Glutamine levels were borderline inversely associated with colorectal cancer risk in EPIC (OR 0.85 per SD, 95% CI 0.75–0.97, FDR P-value=0.08) and similarly in UK Biobank (HR 0.95, 95% CI 0.89–1.01, P=0.09) In both cohorts, associations changed only minimally when cases diagnosed within 2 or 5 years of follow-up were excluded.Conclusions: Higher circulating levels of histidine were associated with a lower risk of colorectal cancer in two large prospective cohorts. Further research to ascertain the role of histidine metabolism and potentially that of glutamine in colorectal cancer development is warranted.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653 a Amino acids
653 a Colorectal cancer
653 a Glutamine
653 a Histidine
7001 a Bešević, Jelenau Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom4 aut
7001 a Dimou, Nikiu International Agency for Research on Cancer (IARC), 150 cours Albert Thomas, Lyon, France4 aut
7001 a Breeur, Marieu International Agency for Research on Cancer (IARC), 150 cours Albert Thomas, Lyon, France4 aut
7001 a Murphy, Neilu International Agency for Research on Cancer (IARC), 150 cours Albert Thomas, Lyon, France4 aut
7001 a Jenab, Mazdau International Agency for Research on Cancer (IARC), 150 cours Albert Thomas, Lyon, France4 aut
7001 a Wedekind, Rolandu International Agency for Research on Cancer (IARC), 150 cours Albert Thomas, Lyon, France4 aut
7001 a Viallon, Vivianu International Agency for Research on Cancer (IARC), 150 cours Albert Thomas, Lyon, France4 aut
7001 a Ferrari, Pietrou International Agency for Research on Cancer (IARC), 150 cours Albert Thomas, Lyon, France4 aut
7001 a Achaintre, Davidu International Agency for Research on Cancer (IARC), 150 cours Albert Thomas, Lyon, France4 aut
7001 a Gicquiau, Audreyu International Agency for Research on Cancer (IARC), 150 cours Albert Thomas, Lyon, France4 aut
7001 a Rinaldi, Sabinau International Agency for Research on Cancer (IARC), 150 cours Albert Thomas, Lyon, France4 aut
7001 a Scalbert, Augustinu International Agency for Research on Cancer (IARC), 150 cours Albert Thomas, Lyon, France4 aut
7001 a Huybrechts, Ingeu International Agency for Research on Cancer (IARC), 150 cours Albert Thomas, Lyon, France4 aut
7001 a Prehn, Corneliau Metabolomics and Proteomics Core, Helmholtz Zentrum München, Neuherberg, Germany4 aut
7001 a Adamski, Jerzyu Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, Singapore, Singapore; Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstraße 1, Neuherberg, Germany; Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, Ljubljana, Slovenia4 aut
7001 a Cross, Amanda J.u School of Public Health, Imperial College London, London, United Kingdom4 aut
7001 a Keun, Hectoru Department of Surgery & Cancer, Imperial College London, London, United Kingdom4 aut
7001 a Chadeau-Hyam, Marcu School of Public Health, Imperial College London, London, United Kingdom4 aut
7001 a Boutron-Ruault, Marie-Christineu Centre for Epidemiology and Population Health (Inserm U1018), Exposome and Heredity team, Faculté de Médecine, Université Paris-Saclay, UVSQ, Gustave Roussy, Villejuif, France4 aut
7001 a Overvad, Kimu Department of Public Health, Aarhus University, Bartholins Allé 2, Aarhus, Denmark4 aut
7001 a Dahm, Christina C.u Department of Public Health, Aarhus University, Bartholins Allé 2, Aarhus, Denmark4 aut
7001 a Nøst, Therese Haugdahlu Faculty of Health Sciences, Department of Community Medicine, UiT the Arctic University of Norway, Tromsø, Norway4 aut
7001 a Sandanger, Torkjel M.u Faculty of Health Sciences, Department of Community Medicine, UiT the Arctic University of Norway, Tromsø, Norway4 aut
7001 a Skeie, Guriu Faculty of Health Sciences, Department of Community Medicine, UiT the Arctic University of Norway, Tromsø, Norway4 aut
7001 a Zamora-Ros, Raulu Unit of Nutrition and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain4 aut
7001 a Tsilidis, Kostas K.u School of Public Health, Imperial College London, London, United Kingdom; Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece4 aut
7001 a Eichelmann, Fabianu German Center for Diabetes Research (DZD), Munchen-Neuherberg, Germany; Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany4 aut
7001 a Schulze, Matthias B.u Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; Institute of Nutritional Science, University of Potsdam, Potsdam, Germany4 aut
7001 a van Guelpen, Bethanyu Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Onkologi4 aut0 (Swepub:umu)beyvan99
7001 a Vidman, Lindau Umeå universitet,Onkologi4 aut0 (Swepub:umu)livi0018
7001 a Sánchez, Maria-Joséu Escuela Andaluza de Salud Pública (EASP), Granada, Spain; Instituto de Investigación Biosanitaria ibs. GRANADA, Granada, Spain; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain4 aut
7001 a Amiano, Pilaru Ministry of Health of the Basque Government, Sub Directorate for Public Health and Addictions of Gipuzkoa, San Sebastián, Spain; Biodonostia Health Research Institute, Epidemiology of Chronic and Communicable Diseases Group, San Sebastián, Spain; Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain4 aut
7001 a Ardanaz, Evau Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Navarra Public Health Institute, Leyre 15, Pamplona, Spain; IdiSNA, Navarra Institute for Health Research, Pamplona, Spain4 aut
7001 a Smith-Byrne, Karlu Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom; International Agency for Research on Cancer (IARC), 150 cours Albert Thomas, Lyon, France4 aut
7001 a Travis, Ruthu Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom4 aut
7001 a Katzke, Verenau German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg, Germany4 aut
7001 a Kaaks, Rudolfu German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg, Germany4 aut
7001 a Derksen, Jeroen W. G.u Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands4 aut
7001 a Colorado-Yohar, Sandrau Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain; Research Group on Demography and Health, National Faculty of Public Health, University of Antioquia, Medellín, Colombia4 aut
7001 a Tumino, Rosariou Cancer Registry and Histopathology Department, Provincial Health Authority (ASP), Ragusa, Italy4 aut
7001 a Bueno-de-Mesquita, Basu Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), PO Box 1, BA, Bilthoven, Netherlands4 aut
7001 a Vineis, Paolou School of Public Health, Imperial College London, London, United Kingdom; Italian Institute of Technology, Genova, Italy4 aut
7001 a Palli, Domenicou Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network – ISPRO, Florence, Italy4 aut
7001 a Pasanisi, Fabriziou Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy4 aut
7001 a Eriksen, Anne Kirstineu Danish Cancer Society Research Center, Diet, Genes and Environment, Strandboulevarden 49, Copenhagen, Denmark; Department of Public Health, University of Copenhagen, Copenhagen, Denmark4 aut
7001 a Tjønneland, Anneu Danish Cancer Society Research Center, Diet, Genes and Environment, Strandboulevarden 49, Copenhagen, Denmark4 aut
7001 a Severi, Gianlucau Centre for Epidemiology and Population Health (Inserm U1018), Exposome and Heredity team, Faculté de Médecine, Université Paris-Saclay, UVSQ, Gustave Roussy, Villejuif, France; Department of Statistics, Computer Science, Applications “G. Parenti” University of Florence, Florence, Italy4 aut
7001 a Gunter, Marc J.u International Agency for Research on Cancer (IARC), 150 cours Albert Thomas, Lyon, France; School of Public Health, Imperial College London, London, United Kingdom4 aut
7102 a Centre for Epidemiology and Population Health (Inserm U1018), Exposome and Heredity team, Faculté de Médecine, Université Paris-Saclay, UVSQ, Gustave Roussy, Villejuif, Franceb Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom4 org
7730 t BMC Medicined : BioMed Central (BMC)g 21:1q 21:1x 1741-7015
8564 u https://doi.org/10.1186/s12916-023-02739-4y Fulltext
8564 u https://umu.diva-portal.org/smash/get/diva2:1743097/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-205643
8564 8u https://doi.org/10.1186/s12916-023-02739-4

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