Sökning: onr:"swepub:oai:DiVA.org:umu-205934" > Genome-wide interac...
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000 | 19166naa a2201393 4500 | |
001 | oai:DiVA.org:umu-205934 | |
003 | SwePub | |
008 | 230327s2023 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:152599961 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-2059342 URI |
024 | 7 | a https://doi.org/10.1158/1055-9965.EPI-22-07632 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1525999612 URI |
040 | a (SwePub)umud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Carreras-Torres, Robertu Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Oncology Data Analytics Program, Catalan Institute of Oncology, L'Hospitalet de Llobregat, Barcelona, Spain; Digestive Diseases and Microbiota Group, Girona Biomedical Research Institute (IDIBGI), Salt, Girona, Spain4 aut |
245 | 1 0 | a Genome-wide interaction study with smoking for colorectal cancer risk identifies novel genetic loci related to tumor suppression, inflammation, and immune response |
264 | 1 | b American association for cancer research,c 2023 |
338 | a print2 rdacarrier | |
520 | a BACKGROUND: Tobacco smoking is an established risk factor for colorectal cancer. However, genetically defined population subgroups may have increased susceptibility to smoking-related effects on colorectal cancer.METHODS: A genome-wide interaction scan was performed including 33,756 colorectal cancer cases and 44,346 controls from three genetic consortia.RESULTS: Evidence of an interaction was observed between smoking status (ever vs. never smokers) and a locus on 3p12.1 (rs9880919, P = 4.58 × 10-8), with higher associated risk in subjects carrying the GG genotype [OR, 1.25; 95% confidence interval (CI), 1.20-1.30] compared with the other genotypes (OR <1.17 for GA and AA). Among ever smokers, we observed interactions between smoking intensity (increase in 10 cigarettes smoked per day) and two loci on 6p21.33 (rs4151657, P = 1.72 × 10-8) and 8q24.23 (rs7005722, P = 2.88 × 10-8). Subjects carrying the rs4151657 TT genotype showed higher risk (OR, 1.12; 95% CI, 1.09-1.16) compared with the other genotypes (OR <1.06 for TC and CC). Similarly, higher risk was observed among subjects carrying the rs7005722 AA genotype (OR, 1.17; 95% CI, 1.07-1.28) compared with the other genotypes (OR <1.13 for AC and CC). Functional annotation revealed that SNPs in 3p12.1 and 6p21.33 loci were located in regulatory regions, and were associated with expression levels of nearby genes. Genetic models predicting gene expression revealed that smoking parameters were associated with lower colorectal cancer risk with higher expression levels of CADM2 (3p12.1) and ATF6B (6p21.33).CONCLUSIONS: Our study identified novel genetic loci that may modulate the risk for colorectal cancer of smoking status and intensity, linked to tumor suppression and immune response.IMPACT: These findings can guide potential prevention treatments. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
700 | 1 | a Kim, Andre E.u Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States4 aut |
700 | 1 | a Lin, Yiu Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States4 aut |
700 | 1 | a Díez-Obrero, Virginiau Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Oncology Data Analytics Program, Catalan Institute of Oncology, L'Hospitalet de Llobregat, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain4 aut |
700 | 1 | a Bien, Stephanie A.u Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States4 aut |
700 | 1 | a Qu, Conghuiu Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States4 aut |
700 | 1 | a Wang, Junu Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States4 aut |
700 | 1 | a Dimou, Nikiu Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France4 aut |
700 | 1 | a Aglago, Elom K.u Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France4 aut |
700 | 1 | a Albanes, Demetriusu Division of Cancer Epidemiology and Genetics, NCI, NIH, MD, Bethesda, Liberia4 aut |
700 | 1 | a Arndt, Volkeru Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany4 aut |
700 | 1 | a Baurley, James W.u Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia4 aut |
700 | 1 | a Berndt, Sonja I.u Division of Cancer Epidemiology and Genetics, NCI, NIH, MD, Bethesda, Liberia4 aut |
700 | 1 | a Bézieau, Stéphaneu Service de Génétique Médicale, Centre Hospitalier Universitaire (CHU) Nantes, Nantes, France4 aut |
700 | 1 | a Bishop, D Timothyu Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, United Kingdom4 aut |
700 | 1 | a Bouras, Emmanouilu Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece4 aut |
700 | 1 | a Brenner, Hermannu Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany4 aut |
700 | 1 | a Budiarto, Arifu Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia4 aut |
700 | 1 | a Campbell, Peter T.u Behavioral and Epidemiology Research Group, American Cancer Society, Atlanta, Georgia4 aut |
700 | 1 | a Casey, Grahamu Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, VA, Charlottesville, United States4 aut |
700 | 1 | a Chan, Andrew T.u Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States4 aut |
700 | 1 | a Chang-Claude, Jennyu Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany4 aut |
700 | 1 | a Chen, Xuechenu Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany4 aut |
700 | 1 | a Conti, David V.u Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States4 aut |
700 | 1 | a Dampier, Christopher H.u Department of General Surgery, University of Virginia School of Medicine, VA, Charlottesville, United States4 aut |
700 | 1 | a Devall, Matthew A Mu Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, VA, Charlottesville, United States4 aut |
700 | 1 | a Drew, David A.u Clinical & Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States4 aut |
700 | 1 | a Figueiredo, Jane C.u Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, CA, Los Angeles, United States4 aut |
700 | 1 | a Gallinger, Stevenu Lunenfeld Tanenbaum Research Institute, University of Toronto, Mount Sinai Hospital, ON, Toronto, Canada4 aut |
700 | 1 | a Giles, Graham G.u Cancer Epidemiology Division, Cancer Council Victoria, VIC, Melbourne, Australia4 aut |
700 | 1 | a Gruber, Stephen B.u Department of Medical Oncology & Therapeutics Research, City of Hope National Medical Center, Duarte, California4 aut |
700 | 1 | a Gsur, Andreau Institute of Cancer Research, Department of Medicine I, Medical University Vienna, Vienna, Austria4 aut |
700 | 1 | a Gunter, Marc J.u Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France4 aut |
700 | 1 | a Harrison, Tabitha A.u Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States4 aut |
700 | 1 | a Hidaka, Akihisau Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States4 aut |
700 | 1 | a Hoffmeister, Michaelu Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany4 aut |
700 | 1 | a Huyghe, Jeroen R.u Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States4 aut |
700 | 1 | a Jenkins, Mark A.u Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, VIC, Melbourne, Australia4 aut |
700 | 1 | a Jordahl, Kristina M.u Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States4 aut |
700 | 1 | a Kawaguchi, Ericu Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States4 aut |
700 | 1 | a Keku, Temitope O.u Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, NC, United States4 aut |
700 | 1 | a Kundaje, Anshulu Department of Genetics, Department of Computer Science, Stanford University, CA, Stanford, United States4 aut |
700 | 1 | a Le Marchand, Loicu University of Hawaii Cancer Center, HI, Honolulu, United States4 aut |
700 | 1 | a Lewinger, Juan Pablou Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States4 aut |
700 | 1 | a Li, Liu Department of Family Medicine, University of Virginia, VA, Charlottesville, United States4 aut |
700 | 1 | a Mahesworo, Bharunou Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia4 aut |
700 | 1 | a Morrison, John L.u Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States4 aut |
700 | 1 | a Murphy, Neilu Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France4 aut |
700 | 1 | a Nan, Hongmeiu Department of Epidemiology, Richard M. Fairbanks School of Public Health, IN, Indianapolis, United States4 aut |
700 | 1 | a Nassir, Ramiu Department of Pathology, School of Medicine, Umm Al-Qura'a University, Saudi Arabia4 aut |
700 | 1 | a Newcomb, Polly A.u Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States4 aut |
700 | 1 | a Obón-Santacana, Mireiau Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Oncology Data Analytics Program, Catalan Institute of Oncology, L'Hospitalet de Llobregat, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain4 aut |
700 | 1 | a Ogino, Shujiu Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, MA, Boston, United States; Department of Oncologic Pathology, Dana-Farber Cancer Institute, MA, Boston, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States; Broad Institute of MIT and Harvard, MA, Cambridge, United States4 aut |
700 | 1 | a Ose, Jenniferu Huntsman Cancer Institute, UT, Salt Lake City, United States; Department of Population Health Sciences, University of Utah, UT, Salt Lake City, United States4 aut |
700 | 1 | a Pai, Rish K.u Department of Laboratory Medicine and Pathology, Mayo Clinic Arizona, AZ, Scottsdale, United States4 aut |
700 | 1 | a Palmer, Julie R.u Slone Epidemiology Center at Boston University, MA, Boston, United States4 aut |
700 | 1 | a Papadimitriou, Nikosu Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France4 aut |
700 | 1 | a Pardamean, Bensu Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia4 aut |
700 | 1 | a Peoples, Anita R.u Huntsman Cancer Institute, UT, Salt Lake City, United States4 aut |
700 | 1 | a Pharoah, Paul D Pu Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom4 aut |
700 | 1 | a Platz, Elizabeth A.u Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, MD, Baltimore, Liberia4 aut |
700 | 1 | a Rennert, Gadu Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel4 aut |
700 | 1 | a Ruiz-Narvaez, Edwardu Department of Nutritional Sciences, University of Michigan School of Public Health, MI, Ann Arbor, United States4 aut |
700 | 1 | a Sakoda, Lori C.u Division of Research, Kaiser Permanente Northern California, CA, Oakland, United States4 aut |
700 | 1 | a Scacheri, Peter C.u Department of Genetics and Genome Sciences, Case Western Reserve University, OH, Cleveland, United States4 aut |
700 | 1 | a Schmit, Stephanie L.u Genomic Medicine Institute, Cleveland Clinic, OH, Cleveland, United States; Population and Cancer Prevention Program, Case Comprehensive Cancer Center, OH, Cleveland, United States4 aut |
700 | 1 | a Schoen, Robert E.u Department of Medicine and Epidemiology, University of Pittsburgh Medical Center, PA, Pittsburgh, United States4 aut |
700 | 1 | a Shcherbina, Annau Biomedical Informatics Program, Dept. of Biomedical Data Sciences, Stanford University, CA, Stanford, United States4 aut |
700 | 1 | a Slattery, Martha L.u Department of Internal Medicine, University of Utah, UT, Salt Lake City, United States4 aut |
700 | 1 | a Stern, Mariana C.u Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States4 aut |
700 | 1 | a Su, Yu-Ruu Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States4 aut |
700 | 1 | a Tangen, Catherine M.u SWOG Statistical Center, Fred Hutchinson Cancer Research Center, WA, Seattle, United States4 aut |
700 | 1 | a Thomas, Duncan C.u Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States4 aut |
700 | 1 | a Tian, Yuu Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; School of Public Health, Capital Medical University, Beijing, China4 aut |
700 | 1 | a Tsilidis, Konstantinos K.u Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom4 aut |
700 | 1 | a Ulrich, Cornelia M.u Huntsman Cancer Institute, UT, Salt Lake City, United States; Department of Population Health Sciences, University of Utah, UT, Salt Lake City, United States4 aut |
700 | 1 | a van Duijnhoven, Fränzel J Bu Division of Human Nutrition and Health, Wageningen University & Research, Wageningen, Netherlands4 aut |
700 | 1 | a van Guelpen, Bethanyu Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Onkologi4 aut0 (Swepub:umu)beyvan99 |
700 | 1 | a Visvanathan, Kalau Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, MD, Baltimore, Liberia4 aut |
700 | 1 | a Vodicka, Pavelu Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, and Biomedical Center, Medical Faculty, Pilsen, Czech Republic4 aut |
700 | 1 | a Cenggoro, Tjeng Wawanu Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia4 aut |
700 | 1 | a Weinstein, Stephanie J.u Division of Cancer Epidemiology and Genetics, NCI, NIH, MD, Bethesda, Liberia4 aut |
700 | 1 | a White, Emilyu Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States4 aut |
700 | 1 | a Wolk, Alicjau Karolinska Institutet4 aut |
700 | 1 | a Woods, Michael O.u Memorial University of Newfoundland, Discipline of Genetics, St. John's, Canada4 aut |
700 | 1 | a Hsu, Liu Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States4 aut |
700 | 1 | a Peters, Ulrikeu Public Health Sciences Division, Fred Hutchinson Cancer Research Center, WA, Seattle, United States; School of Public Health, University of Washington, WA, Seattle, United States4 aut |
700 | 1 | a Moreno, Victoru Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Oncology Data Analytics Program, Catalan Institute of Oncology, L'Hospitalet de Llobregat, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain; Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain4 aut |
700 | 1 | a Gauderman, W. Jamesu Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States4 aut |
710 | 2 | a Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Oncology Data Analytics Program, Catalan Institute of Oncology, L'Hospitalet de Llobregat, Barcelona, Spain; Digestive Diseases and Microbiota Group, Girona Biomedical Research Institute (IDIBGI), Salt, Girona, Spainb Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States4 org |
773 | 0 | t Cancer Epidemiology, Biomarkers and Preventiond : American association for cancer researchg 32:3, s. 315-328q 32:3<315-328x 1055-9965x 1538-7755 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-205934 |
856 | 4 8 | u https://doi.org/10.1158/1055-9965.EPI-22-0763 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:152599961 |
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