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Proinflammatory S10...
Proinflammatory S100A9 stimulates TLR4/NF-κB signaling pathways causing enhanced phagocytic capacity of microglial cells
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- Zhang, Xiaoyin (författare)
- Laboratory of stem cell and Tissue Engineering, Chongqing Medical University, Chongqing, China
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- Sun, Dan (författare)
- State Key Laboratory of Photon-Technology in Western China Energy, Institute of Photonics and Photon Technology, Northwest University, Xi'an, China
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- Zhou, Xin (författare)
- Laboratory of stem cell and Tissue Engineering, Chongqing Medical University, Chongqing, China
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- Zhang, Ce (författare)
- State Key Laboratory of Photon-Technology in Western China Energy, Institute of Photonics and Photon Technology, Northwest University, Xi'an, China
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- Yin, Qing (författare)
- Laboratory of stem cell and Tissue Engineering, Chongqing Medical University, Chongqing, China
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- Chen, Li (författare)
- Laboratory of stem cell and Tissue Engineering, Chongqing Medical University, Chongqing, China
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- Tang, Yong (författare)
- Laboratory of stem cell and Tissue Engineering, Chongqing Medical University, Chongqing, China
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- Liu, Yonggang (författare)
- Laboratory of stem cell and Tissue Engineering, Chongqing Medical University, Chongqing, China
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- Morozova-Roche, Ludmilla A. (författare)
- Umeå universitet,Institutionen för medicinsk kemi och biofysik
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(creator_code:org_t)
- Elsevier, 2023
- 2023
- Engelska.
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Ingår i: Immunology Letters. - : Elsevier. - 0165-2478 .- 1879-0542. ; 255, s. 54-61
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Alzheimer's disease (AD) is the main cause of dementia, affecting the increasingly aging population. Growing evidence indicates that neuro-inflammation plays crucial roles, e.g., the association between AD risk genes with innate immune functions. In this study, we demonstrate that moderate concentrations of pro-inflammatory cytokine S100A9 regulate immune response of BV2 microglial cells, i.e., the phagocytic capacity, reflected by elevated number of 1 μm diameter Dsred-stained latex beads in the cytoplasm. In contrast, at high S100A9 concentrations, both the viability and phagocytic capacity of BV2 cells drop substantially. Furthermore, it is uncovered that S100A9 affects phagocytosis of microglia via NF-κB signaling pathways. Application of related target-specific drugs, i.e., IKK and TLR4 inhibitors, effectively suppresses BV2 cells’ immune responses. These results suggest that pro-inflammatory S100A9 activates microglial phagocytosis, and possibly contributes to the clearance of amyloidogenic species at the early stage of AD.
Ämnesord
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Nyckelord
- Alzheimer's disease
- Microglia
- Neuroinflammation
- Phagocytosis
- S100A9
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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