Sökning: onr:"swepub:oai:DiVA.org:umu-206300" > The association bet...
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000 | 07833naa a2201549 4500 | |
001 | oai:DiVA.org:umu-206300 | |
003 | SwePub | |
008 | 230404s2019 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:141845725 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-2063002 URI |
024 | 7 | a https://doi.org/10.1016/j.biopsych.2019.03.9852 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1418457252 URI |
040 | a (SwePub)umud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a de Zwarte, Sonja M. C.4 aut |
245 | 1 0 | a The association between familial risk and brain abnormalities is disease specific :b an ENIGMA-relatives study of schizophrenia and bipolar disorder |
264 | 1 | b Elsevier,c 2019 |
338 | a electronic2 rdacarrier | |
520 | a BACKGROUND: Schizophrenia and bipolar disorder share genetic liability, and some structural brain abnormalities are common to both conditions. First-degree relatives of patients with schizophrenia (FDRs-SZ) show similar brain abnormalities to patients, albeit with smaller effect sizes. Imaging findings in first-degree relatives of patients with bipolar disorder (FDRs-BD) have been inconsistent in the past, but recent studies report regionally greater volumes compared with control subjects.METHODS: We performed a meta-analysis of global and subcortical brain measures of 6008 individuals (1228 FDRs-SZ, 852 FDRs-BD, 2246 control subjects, 1016 patients with schizophrenia, 666 patients with bipolar disorder) from 34 schizophrenia and/or bipolar disorder family cohorts with standardized methods. Analyses were repeated with a correction for intracranial volume (ICV) and for the presence of any psychopathology in the relatives and control subjects.RESULTS: FDRs-BD had significantly larger ICV (d = +0.16, q < .05 corrected), whereas FDRs-SZ showed smaller thalamic volumes than control subjects (d = -0.12, q < .05 corrected). ICV explained the enlargements in the brain measures in FDRs-BD. In FDRs-SZ, after correction for ICV, total brain, cortical gray matter, cerebral white matter, cerebellar gray and white matter, and thalamus volumes were significantly smaller; the cortex was thinner (d < -0.09, q < .05 corrected); and third ventricle was larger (d = +0.15, q < .05 corrected). The findings were not explained by psychopathology in the relatives or control subjects.CONCLUSIONS: Despite shared genetic liability, FDRs-SZ and FDRs-BD show a differential pattern of structural brain abnormalities, specifically a divergent effect in ICV. This may imply that the neurodevelopmental trajectories leading to brain anomalies in schizophrenia or bipolar disorder are distinct. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng |
653 | a Bipolar disorder | |
653 | a Familial risk | |
653 | a Imaging | |
653 | a Meta-analysis | |
653 | a Neurodevelopment | |
653 | a Schizophrenia | |
700 | 1 | a Brouwer, Rachel M.4 aut |
700 | 1 | a Agartz, Ingridu Karolinska Institutet4 aut |
700 | 1 | a Alda, Martin4 aut |
700 | 1 | a Aleman, André4 aut |
700 | 1 | a Alpert, Kathryn I.4 aut |
700 | 1 | a Bearden, Carrie E.4 aut |
700 | 1 | a Bertolino, Alessandro4 aut |
700 | 1 | a Bois, Catherine4 aut |
700 | 1 | a Bonvino, Aurora4 aut |
700 | 1 | a Bramon, Elvira4 aut |
700 | 1 | a Buimer, Elizabeth E. L.4 aut |
700 | 1 | a Cahn, Wiepke4 aut |
700 | 1 | a Cannon, Dara M.4 aut |
700 | 1 | a Cannon, Tyrone D.4 aut |
700 | 1 | a Caseras, Xavier4 aut |
700 | 1 | a Castro-Fornieles, Josefina4 aut |
700 | 1 | a Chen, Qiang4 aut |
700 | 1 | a Chung, Yoonho4 aut |
700 | 1 | a De la Serna, Elena4 aut |
700 | 1 | a Di Giorgio, Annabella4 aut |
700 | 1 | a Doucet, Gaelle E.4 aut |
700 | 1 | a Eker, Mehmet Cagdas4 aut |
700 | 1 | a Erk, Susanne4 aut |
700 | 1 | a Fears, Scott C.4 aut |
700 | 1 | a Foley, Sonya F.4 aut |
700 | 1 | a Frangou, Sophia4 aut |
700 | 1 | a Frankland, Andrew4 aut |
700 | 1 | a Fullerton, Janice M.4 aut |
700 | 1 | a Glahn, David C.4 aut |
700 | 1 | a Goghari, Vina M.4 aut |
700 | 1 | a Goldman, Aaron L.4 aut |
700 | 1 | a Gonul, Ali Saffet4 aut |
700 | 1 | a Gruber, Oliver4 aut |
700 | 1 | a de Haan, Lieuwe4 aut |
700 | 1 | a Hajek, Tomas4 aut |
700 | 1 | a Hawkins, Emma L.4 aut |
700 | 1 | a Heinz, Andreas4 aut |
700 | 1 | a Hillegers, Manon H. J.4 aut |
700 | 1 | a Hulshoff Pol, Hilleke E.4 aut |
700 | 1 | a Hultman, Christina M.4 aut |
700 | 1 | a Ingvar, Martinu Karolinska Institutet4 aut |
700 | 1 | a Johansson, Viktoriau Karolinska Institutet4 aut0 (Swepub:umu)vijo2972 |
700 | 1 | a Jönsson, Erik G.u Karolinska Institutet4 aut |
700 | 1 | a Kane, Fergus4 aut |
700 | 1 | a Kempton, Matthew J.4 aut |
700 | 1 | a Koenis, Marinka M. G.4 aut |
700 | 1 | a Kopecek, Miloslav4 aut |
700 | 1 | a Krabbendam, Lydia4 aut |
700 | 1 | a Krämer, Bernd4 aut |
700 | 1 | a Lawrie, Stephen M.4 aut |
700 | 1 | a Lenroot, Rhoshel K.4 aut |
700 | 1 | a Marcelis, Machteld4 aut |
700 | 1 | a Marsman, Jan-Bernard C.4 aut |
700 | 1 | a Mattay, Venkata S.4 aut |
700 | 1 | a McDonald, Colm4 aut |
700 | 1 | a Meyer-Lindenberg, Andreas4 aut |
700 | 1 | a Michielse, Stijn4 aut |
700 | 1 | a Mitchell, Philip B.4 aut |
700 | 1 | a Moreno, Dolores4 aut |
700 | 1 | a Murray, Robin M.4 aut |
700 | 1 | a Mwangi, Benson4 aut |
700 | 1 | a Najt, Pablo4 aut |
700 | 1 | a Neilson, Emma4 aut |
700 | 1 | a Newport, Jason4 aut |
700 | 1 | a van Os, Jim4 aut |
700 | 1 | a Overs, Bronwyn4 aut |
700 | 1 | a Ozerdem, Aysegul4 aut |
700 | 1 | a Picchioni, Marco M.4 aut |
700 | 1 | a Richter, Anja4 aut |
700 | 1 | a Roberts, Gloria4 aut |
700 | 1 | a Aydogan, Aybala Saricicek4 aut |
700 | 1 | a Schofield, Peter R.4 aut |
700 | 1 | a Simsek, Fatma4 aut |
700 | 1 | a Soares, Jair C.4 aut |
700 | 1 | a Sugranyes, Gisela4 aut |
700 | 1 | a Toulopoulou, Timothea4 aut |
700 | 1 | a Tronchin, Giulia4 aut |
700 | 1 | a Walter, Henrik4 aut |
700 | 1 | a Wang, Lei4 aut |
700 | 1 | a Weinberger, Daniel R.4 aut |
700 | 1 | a Whalley, Heather C.4 aut |
700 | 1 | a Yalin, Nefize4 aut |
700 | 1 | a Andreassen, Ole A.4 aut |
700 | 1 | a Ching, Christopher R. K.4 aut |
700 | 1 | a van Erp, Theo G. M.4 aut |
700 | 1 | a Turner, Jessica A.4 aut |
700 | 1 | a Jahanshad, Neda4 aut |
700 | 1 | a Thompson, Paul M.4 aut |
700 | 1 | a Kahn, René S.4 aut |
700 | 1 | a van Haren, Neeltje E. M.4 aut |
710 | 2 | a Karolinska Institutet4 org |
773 | 0 | t Biological Psychiatryd : Elsevierg 86:7, s. 545-556q 86:7<545-556x 0006-3223x 1873-2402 |
856 | 4 | u https://doi.org/10.1016/j.biopsych.2019.03.985y Fulltext |
856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:1748808/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u http://www.biologicalpsychiatryjournal.com/article/S0006322319314374/pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-206300 |
856 | 4 8 | u https://doi.org/10.1016/j.biopsych.2019.03.985 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:141845725 |
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