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Prediagnostic serum...
Prediagnostic serum glyceraldehyde-derived advanced glycation end products and mortality among colorectal cancer patients
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- Mao, Ziling (författare)
- Department of Epidemiology, Rollins School of Public Health, Emory University, GA, Atlanta, United States; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA, Pittsburgh, United States
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- Baker, Jacqueline Roshelli (författare)
- Department of Epidemiology, Rollins School of Public Health, Emory University, GA, Atlanta, United States
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- Takeuchi, Masayoshi (författare)
- Department of Advanced Medicine, Medical Research Institute, Kanazawa Medical University, Ishikawa, Japan
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- Hyogo, Hideyuki (författare)
- Department of Gastroenterology and Metabolism, Hiroshima University Hospital, Hiroshima, Japan; Lifecare Clinic Hiroshima, Hiroshima, Japan
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- Tjønneland, Anne (författare)
- Danish Cancer Society Research Center, Diet, Cancer and Health, Copenhagen, Denmark; Department of Public Health, University of Copenhagen, Copenhagen, Denmark
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- Eriksen, Anne Kirstine (författare)
- Danish Cancer Society Research Center, Diet, Cancer and Health, Copenhagen, Denmark
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- Severi, Gianluca (författare)
- UVSQ, Inserm, Centre for Epidemiology and Population Health (U1018), Exposome and Heredity Team, Université Paris-Saclay, Villejuif, France; Department of Statistics, Computer Science Applications, “G. Parenti” University of Florence, Florence, Italy
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- Rothwell, Joseph (författare)
- UVSQ, Inserm, Centre for Epidemiology and Population Health (U1018), Exposome and Heredity Team, Université Paris-Saclay, Villejuif, France
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- Laouali, Nasser (författare)
- UVSQ, Inserm, Centre for Epidemiology and Population Health (U1018), Exposome and Heredity Team, Université Paris-Saclay, Villejuif, France
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- Katzke, Verena (författare)
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Kaaks, Rudolf (författare)
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Schulze, Matthias B. (författare)
- Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany
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- Palli, Domenico (författare)
- Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network – ISPRO, Florence, Italy
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- Sieri, Sabina (författare)
- Epidemiology and Prevention Unit, Fondazione IRCCS, Istituto Nazionale dei Tumori di Milano Via Venezian, Milan, Italy
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- de Magistris, Maria Santucci (författare)
- Azienda Ospedaliera Universitaria Federico II, Naples, Italy
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- Tumino, Rosario (författare)
- Hyblean Association for Epidemiological Research, AIRE ONLUS, Ragusa, Italy
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- Sacerdote, Carlotta (författare)
- Unit of Cancer Epidemiology, Città della Salute e della Scienza University-Hospital, Turin, Italy
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- Derksen, Jeroen W. G. (författare)
- Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands
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- Gram, Inger T. (författare)
- Department of Community Medicine, UiT-The Arctic University of Norway, Tromsø, Norway
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- Skeie, Guri (författare)
- Department of Community Medicine, UiT-The Arctic University of Norway, Tromsø, Norway
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- Sandanger, Torkjel M. (författare)
- Department of Community Medicine, UiT-The Arctic University of Norway, Tromsø, Norway
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- Quirós, Jose Ramón (författare)
- Public Health Directorate, Asturias, Spain
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- Crous-Bou, Marta (författare)
- Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO) - Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States
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- Sánchez, Maria-Jose (författare)
- Escuela Andaluza de Salud Pública (EASP), Granada, Spain; Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain; Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain; Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain
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- Amiano, Pilar (författare)
- Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain; Ministry of Health of the Basque Government, Sub Directorate for Public Health and Addictions of Gipuzkoa, San Sebastian, Spain; Epidemiology of Chronic and Communicable Diseases Group, Biodonostia Health Research Institute, San Sebastián, Spain
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- Colorado-Yohar, Sandra M. (författare)
- Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain; Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain; Research Group on Demography and Health, National Faculty of Public Health, University of Antioquia, Medellín, Colombia
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- Guevara, Marcela (författare)
- Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain; Navarra Public Health Institute, Pamplona, Spain; Navarra Institute for Health Research (IdiSNA), Pamplona, Spain
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- Harlid, Sophia, 1978- (författare)
- Umeå universitet,Institutionen för strålningsvetenskaper
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- Johansson, Ingegerd (författare)
- Umeå universitet,Institutionen för odontologi
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- Perez-Cornago, Aurora (författare)
- Cancer Epidemiology Unit (CEU), Nuffield Department of Population Health, Medical Sciences Division, University of Oxford, Oxford, United Kingdom
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- Freisling, Heinz (författare)
- Section of Nutrition and Metabolism, Nutritional Epidemiology Group, International Agency for Research on Cancer, World Health Organization (IARC-WHO), Lyon, France
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- Gunter, Marc (författare)
- Section of Nutrition and Metabolism, Nutritional Epidemiology Group, International Agency for Research on Cancer, World Health Organization (IARC-WHO), Lyon, France
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- Weiderpass, Elisabete (författare)
- Office of the Director, International Agency for Research on Cancer (IARC-WHO), Lyon, France
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- Heath, Alicia K. (författare)
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
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- Aglago, Elom (författare)
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
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- Jenab, Mazda (författare)
- Section of Nutrition and Metabolism, Nutritional Epidemiology Group, International Agency for Research on Cancer, World Health Organization (IARC-WHO), Lyon, France
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- Fedirko, Veronika (författare)
- Department of Epidemiology, Rollins School of Public Health, Emory University, GA, Atlanta, United States; MD Anderson Cancer Center, TX, Houston, United States
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(creator_code:org_t)
- 2023-03-20
- 2023
- Engelska.
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Ingår i: International Journal of Cancer. - : John Wiley & Sons. - 0020-7136 .- 1097-0215. ; 152:11, s. 2257-2268
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Glyceraldehyde-derived advanced glycation end products (glycer-AGEs) could contribute to colorectal cancer development and progression due to their pro-oxidative and pro-inflammatory properties. However, the association of glycer-AGEs with mortality after colorectal cancer diagnosis has not been previously investigated. Circulating glycer-AGEs were measured by competitive ELISA. Multivariable Cox proportional hazards models were used to calculate hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) for associations of circulating glycer-AGEs concentrations with CRC-specific and all-cause mortality among 1034 colorectal cancer (CRC) cases identified within the European Prospective Investigation into Cancer and Nutrition (EPIC) study between 1993 and 2013. During a mean of 48 months of follow-up, 529 participants died (409 from CRC). Glycer-AGEs were statistically significantly positively associated with CRC-specific (HRQ5 vs Q1 = 1.53, 95% CI: 1.04-2.25, Ptrend =.002) and all-cause (HRQ5 vs Q1 = 1.62, 95% CI: 1.16-2.26, Ptrend <.001) mortality among individuals with CRC. There was suggestion of a stronger association between glycer-AGEs and CRC-specific mortality among patients with distal colon cancer (per SD increment: HRproximal colon = 1.02, 95% CI: 0.74-1.42; HRdistal colon = 1.51, 95% CI: 1.20-1.91; Peffect modification =.02). The highest HR was observed among CRC cases in the highest body mass index (BMI) and glycer-AGEs category relative to lowest BMI and glycer-AGEs category for both CRC-specific (HR = 1.78, 95% CI: 1.02-3.01) and all-cause mortality (HR = 2.15, 95% CI: 1.33-3.47), although no statistically significant effect modification was observed. Our study found that prediagnostic circulating glycer-AGEs are positively associated with CRC-specific and all-cause mortality among individuals with CRC. Further investigations in other populations and stratifying by tumor location and BMI are warranted.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Nyckelord
- advanced glycation end products
- colorectal cancer
- glyceraldehyde-derived advanced glycation end products
- mortality
- prospective study
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- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Mao, Ziling
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Baker, Jacquelin ...
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Takeuchi, Masayo ...
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Hyogo, Hideyuki
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Tjønneland, Anne
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Eriksen, Anne Ki ...
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visa fler...
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Severi, Gianluca
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Rothwell, Joseph
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Laouali, Nasser
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Katzke, Verena
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Kaaks, Rudolf
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Schulze, Matthia ...
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Palli, Domenico
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Sieri, Sabina
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de Magistris, Ma ...
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Tumino, Rosario
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Sacerdote, Carlo ...
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Derksen, Jeroen ...
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Gram, Inger T.
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Skeie, Guri
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Sandanger, Torkj ...
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Quirós, Jose Ram ...
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Crous-Bou, Marta
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Sánchez, Maria-J ...
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Amiano, Pilar
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Colorado-Yohar, ...
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Guevara, Marcela
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Harlid, Sophia, ...
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Johansson, Ingeg ...
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Perez-Cornago, A ...
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Freisling, Heinz
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Gunter, Marc
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Weiderpass, Elis ...
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Heath, Alicia K.
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Aglago, Elom
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Jenab, Mazda
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Fedirko, Veronik ...
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