Sökning: onr:"swepub:oai:DiVA.org:umu-206343" > Prediagnostic serum...
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000 | 10625naa a2200781 4500 | |
001 | oai:DiVA.org:umu-206343 | |
003 | SwePub | |
008 | 230428s2023 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-2063432 URI |
024 | 7 | a https://doi.org/10.1002/ijc.344492 DOI |
040 | a (SwePub)umu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Mao, Zilingu Department of Epidemiology, Rollins School of Public Health, Emory University, GA, Atlanta, United States; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA, Pittsburgh, United States4 aut |
245 | 1 0 | a Prediagnostic serum glyceraldehyde-derived advanced glycation end products and mortality among colorectal cancer patients |
264 | c 2023-03-20 | |
264 | 1 | b John Wiley & Sons,c 2023 |
338 | a print2 rdacarrier | |
520 | a Glyceraldehyde-derived advanced glycation end products (glycer-AGEs) could contribute to colorectal cancer development and progression due to their pro-oxidative and pro-inflammatory properties. However, the association of glycer-AGEs with mortality after colorectal cancer diagnosis has not been previously investigated. Circulating glycer-AGEs were measured by competitive ELISA. Multivariable Cox proportional hazards models were used to calculate hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) for associations of circulating glycer-AGEs concentrations with CRC-specific and all-cause mortality among 1034 colorectal cancer (CRC) cases identified within the European Prospective Investigation into Cancer and Nutrition (EPIC) study between 1993 and 2013. During a mean of 48 months of follow-up, 529 participants died (409 from CRC). Glycer-AGEs were statistically significantly positively associated with CRC-specific (HRQ5 vs Q1 = 1.53, 95% CI: 1.04-2.25, Ptrend =.002) and all-cause (HRQ5 vs Q1 = 1.62, 95% CI: 1.16-2.26, Ptrend <.001) mortality among individuals with CRC. There was suggestion of a stronger association between glycer-AGEs and CRC-specific mortality among patients with distal colon cancer (per SD increment: HRproximal colon = 1.02, 95% CI: 0.74-1.42; HRdistal colon = 1.51, 95% CI: 1.20-1.91; Peffect modification =.02). The highest HR was observed among CRC cases in the highest body mass index (BMI) and glycer-AGEs category relative to lowest BMI and glycer-AGEs category for both CRC-specific (HR = 1.78, 95% CI: 1.02-3.01) and all-cause mortality (HR = 2.15, 95% CI: 1.33-3.47), although no statistically significant effect modification was observed. Our study found that prediagnostic circulating glycer-AGEs are positively associated with CRC-specific and all-cause mortality among individuals with CRC. Further investigations in other populations and stratifying by tumor location and BMI are warranted. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Arbetsmedicin och miljömedicin0 (SwePub)303032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Occupational Health and Environmental Health0 (SwePub)303032 hsv//eng |
653 | a advanced glycation end products | |
653 | a colorectal cancer | |
653 | a glyceraldehyde-derived advanced glycation end products | |
653 | a mortality | |
653 | a prospective study | |
700 | 1 | a Baker, Jacqueline Roshelliu Department of Epidemiology, Rollins School of Public Health, Emory University, GA, Atlanta, United States4 aut |
700 | 1 | a Takeuchi, Masayoshiu Department of Advanced Medicine, Medical Research Institute, Kanazawa Medical University, Ishikawa, Japan4 aut |
700 | 1 | a Hyogo, Hideyukiu Department of Gastroenterology and Metabolism, Hiroshima University Hospital, Hiroshima, Japan; Lifecare Clinic Hiroshima, Hiroshima, Japan4 aut |
700 | 1 | a Tjønneland, Anneu Danish Cancer Society Research Center, Diet, Cancer and Health, Copenhagen, Denmark; Department of Public Health, University of Copenhagen, Copenhagen, Denmark4 aut |
700 | 1 | a Eriksen, Anne Kirstineu Danish Cancer Society Research Center, Diet, Cancer and Health, Copenhagen, Denmark4 aut |
700 | 1 | a Severi, Gianlucau UVSQ, Inserm, Centre for Epidemiology and Population Health (U1018), Exposome and Heredity Team, Université Paris-Saclay, Villejuif, France; Department of Statistics, Computer Science Applications, “G. Parenti” University of Florence, Florence, Italy4 aut |
700 | 1 | a Rothwell, Josephu UVSQ, Inserm, Centre for Epidemiology and Population Health (U1018), Exposome and Heredity Team, Université Paris-Saclay, Villejuif, France4 aut |
700 | 1 | a Laouali, Nasseru UVSQ, Inserm, Centre for Epidemiology and Population Health (U1018), Exposome and Heredity Team, Université Paris-Saclay, Villejuif, France4 aut |
700 | 1 | a Katzke, Verenau Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany4 aut |
700 | 1 | a Kaaks, Rudolfu Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany4 aut |
700 | 1 | a Schulze, Matthias B.u Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany4 aut |
700 | 1 | a Palli, Domenicou Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network – ISPRO, Florence, Italy4 aut |
700 | 1 | a Sieri, Sabinau Epidemiology and Prevention Unit, Fondazione IRCCS, Istituto Nazionale dei Tumori di Milano Via Venezian, Milan, Italy4 aut |
700 | 1 | a de Magistris, Maria Santucciu Azienda Ospedaliera Universitaria Federico II, Naples, Italy4 aut |
700 | 1 | a Tumino, Rosariou Hyblean Association for Epidemiological Research, AIRE ONLUS, Ragusa, Italy4 aut |
700 | 1 | a Sacerdote, Carlottau Unit of Cancer Epidemiology, Città della Salute e della Scienza University-Hospital, Turin, Italy4 aut |
700 | 1 | a Derksen, Jeroen W. G.u Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands4 aut |
700 | 1 | a Gram, Inger T.u Department of Community Medicine, UiT-The Arctic University of Norway, Tromsø, Norway4 aut |
700 | 1 | a Skeie, Guriu Department of Community Medicine, UiT-The Arctic University of Norway, Tromsø, Norway4 aut |
700 | 1 | a Sandanger, Torkjel M.u Department of Community Medicine, UiT-The Arctic University of Norway, Tromsø, Norway4 aut |
700 | 1 | a Quirós, Jose Ramónu Public Health Directorate, Asturias, Spain4 aut |
700 | 1 | a Crous-Bou, Martau Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO) - Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States4 aut |
700 | 1 | a Sánchez, Maria-Joseu Escuela Andaluza de Salud Pública (EASP), Granada, Spain; Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain; Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain; Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain4 aut |
700 | 1 | a Amiano, Pilaru Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain; Ministry of Health of the Basque Government, Sub Directorate for Public Health and Addictions of Gipuzkoa, San Sebastian, Spain; Epidemiology of Chronic and Communicable Diseases Group, Biodonostia Health Research Institute, San Sebastián, Spain4 aut |
700 | 1 | a Colorado-Yohar, Sandra M.u Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain; Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain; Research Group on Demography and Health, National Faculty of Public Health, University of Antioquia, Medellín, Colombia4 aut |
700 | 1 | a Guevara, Marcelau Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain; Navarra Public Health Institute, Pamplona, Spain; Navarra Institute for Health Research (IdiSNA), Pamplona, Spain4 aut |
700 | 1 | a Harlid, Sophia,d 1978-u Umeå universitet,Institutionen för strålningsvetenskaper4 aut0 (Swepub:umu)soha0105 |
700 | 1 | a Johansson, Ingegerdu Umeå universitet,Institutionen för odontologi4 aut0 (Swepub:umu)injo0003 |
700 | 1 | a Perez-Cornago, Aurorau Cancer Epidemiology Unit (CEU), Nuffield Department of Population Health, Medical Sciences Division, University of Oxford, Oxford, United Kingdom4 aut |
700 | 1 | a Freisling, Heinzu Section of Nutrition and Metabolism, Nutritional Epidemiology Group, International Agency for Research on Cancer, World Health Organization (IARC-WHO), Lyon, France4 aut |
700 | 1 | a Gunter, Marcu Section of Nutrition and Metabolism, Nutritional Epidemiology Group, International Agency for Research on Cancer, World Health Organization (IARC-WHO), Lyon, France4 aut |
700 | 1 | a Weiderpass, Elisabeteu Office of the Director, International Agency for Research on Cancer (IARC-WHO), Lyon, France4 aut |
700 | 1 | a Heath, Alicia K.u Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom4 aut |
700 | 1 | a Aglago, Elomu Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom4 aut |
700 | 1 | a Jenab, Mazdau Section of Nutrition and Metabolism, Nutritional Epidemiology Group, International Agency for Research on Cancer, World Health Organization (IARC-WHO), Lyon, France4 aut |
700 | 1 | a Fedirko, Veronikau Department of Epidemiology, Rollins School of Public Health, Emory University, GA, Atlanta, United States; MD Anderson Cancer Center, TX, Houston, United States4 aut |
710 | 2 | a Department of Epidemiology, Rollins School of Public Health, Emory University, GA, Atlanta, United States; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA, Pittsburgh, United Statesb Department of Epidemiology, Rollins School of Public Health, Emory University, GA, Atlanta, United States4 org |
773 | 0 | t International Journal of Cancerd : John Wiley & Sonsg 152:11, s. 2257-2268q 152:11<2257-2268x 0020-7136x 1097-0215 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-206343 |
856 | 4 8 | u https://doi.org/10.1002/ijc.34449 |
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