Sialic acid is a cellular receptor for coxsackievirus A24 variant, an emerging virus with pandemic potential

Binding to target cell receptors is a critical step in the virus life cycle. Coxsackievirus A24 variant (CVA24v) has pandemic potential and is a major cause of acute hemorrhagic conjunctivitis, but its cellular receptor has hitherto been unknown. Here we show that CVA24v fails to bind to and infect CHO cells defective in sialic acid expression. Binding of CVA24v to and infection of corneal epithelial cells are efficiently inhibited by treating cells with a sialic acid-cleaving enzyme or sialic acid-binding lectins and by treatment of the virus with soluble, multivalent sialic acid. Protease treatment of cells efficiently inhibited virus binding, suggesting that the receptor is a sialylated glycoprotein. Like enterovirus type 70 and influenza A virus, CVA24v can cause pandemics. Remarkably, all three viruses use the same receptor. Since several unrelated viruses with tropism for the eye use this receptor, sialic acid-based antiviral drugs that prevent virus entry may be useful for topical treatment of such infections.

Jamshidi, FaribaUmeå universitet,Virologi (författare)
Johansson, Susanne M. C.Umeå universitet,Kemiska institutionen (författare)
Oberste, M StevenDivision of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia (författare)
Arnberg, NiklasUmeå universitet,Virologi(Swepub:umu)niar0001 (författare)
Umeå universitetVirologi (creator_code:org_t)

Ingår i:Journal of VirologyBaltimore : American Society for Microbiology82:6, s. 3061-30680022-538X1098-5514

Av författaren/redakt...: Nilsson, Emma C; Jamshidi, Fariba; Johansson, Susan ...; Oberste, M Steve ...; Arnberg, Niklas

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinska och f ...; och Mikrobiologi ino ...

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.