Sökning: onr:"swepub:oai:DiVA.org:umu-21104" > Iodine-131 induces ...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 03661naa a2200433 4500 | |
001 | oai:DiVA.org:umu-21104 | |
003 | SwePub | |
008 | 090402s2008 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-211042 URI |
024 | 7 | a https://doi.org/10.1089/cbr.2007.04712 DOI |
040 | a (SwePub)umu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Eriksson, Davidu Umeå universitet,Immunologi/immunkemi,Stigbrand4 aut0 (Swepub:umu)daer0001 |
245 | 1 0 | a Iodine-131 induces mitotic catastrophes and activates apoptotic pathways in HeLa Hep2 cells |
264 | c 2008-11-05 | |
264 | 1 | b Mary Ann Liebert Inc,c 2008 |
338 | a print2 rdacarrier | |
520 | a Iodine-131 (131I) has been used both in unconjugated form and conjugated to antibody derivates (i.e., radioimmunotherapy; RIT) to treat malignant diseases. The mechanisms by which 131I-irradiation causes growth retardation are, however, inadequately understood. The aim of this study was to elucidate the sequential molecular and cellular events that initiate cell death in HeLa Hep2 cells exposed to 131I. In this paper, HeLa Hep2 cells were found to display a transient G2-M arrest following irradiation, but then reentered the cell cycle still containing unrepaired cellular damage. An increase of multipolar mitotic spindles, as well as a significant increase in centrosome numbers from 8.8% +/- 1.9% in controls to 54.7% +/- 2.2% in irradiated cells, was observed (p < 0.0001). A subsequent failure of cytokinesis caused the cells to progress into mitotic catastrophe. This was accompanied by the formation of giant cells with multiple nuclei, multilobulated nuclei, and an increased frequency of polyploidy cells. A fraction of the cells also displayed apoptotic features, including the activation of initiator caspases-2, -8, -9, and effector caspase-3, as well as cleavage of poly(ADP-ribose) polymerase, a cell-death substrate for active caspase-3. These findings demonstrate that mitotic catastrophes and the activation of a delayed type of apoptosis might be important mechanisms involved in cell death following the RIT of solid tumors with -emitting radionuclides, such as 131I. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng |
653 | a iodine-131 | |
653 | a mitotic catastrophe | |
653 | a apoptosis | |
653 | a caspases | |
653 | a centrosomes | |
653 | a radioimmunotherapy | |
700 | 1 | a Blomberg, Jeanetteu Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten)4 aut0 (Swepub:umu)jebl0001 |
700 | 1 | a Lindgren, Theresu Umeå universitet,Immunologi/immunkemi,Stigbrand4 aut0 (Swepub:umu)thslin02 |
700 | 1 | a Löfroth, Per-Olovu Umeå universitet,Radiofysik4 aut |
700 | 1 | a Johansson, Lennartu Umeå universitet,Radiofysik4 aut0 (Swepub:umu)lejo0023 |
700 | 1 | a Riklund, Katrineu Umeå universitet,Diagnostisk radiologi4 aut0 (Swepub:umu)kaah0001 |
700 | 1 | a Stigbrand, Torgnyu Umeå universitet,Immunologi/immunkemi,Stigbrand4 aut0 (Swepub:umu)tost0001 |
710 | 2 | a Umeå universitetb Immunologi/immunkemi4 org |
773 | 0 | t Cancer Biotherapy and Radiopharmaceuticalsd : Mary Ann Liebert Incg 23:5, s. 541-549q 23:5<541-549x 1084-9785x 1557-8852 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-21104 |
856 | 4 8 | u https://doi.org/10.1089/cbr.2007.0471 |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
Kopiera och spara länken för att återkomma till aktuell vy