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Isoallopregnanolone...
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Bäckström, TorbjörnUmeå universitet,Obstetrik och gynekologi
(författare)
Isoallopregnanolone inhibits estrus cycle-dependent aggressive behavior
- Artikel/kapitelEngelska2023
Förlag, utgivningsår, omfång ...
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MDPI,2023
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electronicrdacarrier
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LIBRIS-ID:oai:DiVA.org:umu-212055
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-212055URI
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https://doi.org/10.3390/biom13061017DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Among female rats, some individuals show estrus cycle-dependent irritability/aggressive behaviors, and these individual rats may be used as a model for premenstrual dysphoric disorder (PMDD). We wanted to investigate if these behaviors are related to the estrus cycle phase containing moderately increased levels of positive GABA-A receptor-modulating steroids (steroid-PAM), especially allopregnanolone (ALLO), and if the adverse behavior can be antagonized. The electrophysiology studies in this paper show that isoallopregnanolone (ISO) is a GABA-A-modulating steroid antagonist (GAMSA), meaning that ISO can antagonize the agonistic effects of positive GABA-A receptor-modulating steroids in both α1β2γ2L and α4β3δ GABA-A receptor subtypes. In this study, we also investigated whether ISO could antagonize the estrus cycle-dependent aggressive behaviors in female Wistar rats using a resident–intruder test. Our results confirmed previous reports of estrus cycle-dependent behaviors in that 42% of the tested rats showed higher levels of irritability/aggression at diestrus compared to those at estrus. Furthermore, we found that, during the treatment with ISO, the aggressive behavior at diestrus was alleviated to a level comparable to that of estrus. We noticed an 89% reduction in the increase in aggressive behavior at diestrus compared to that at estrus. Vehicle treatment in the same animals showed a minimal effect on the diestrus-related aggressive behavior. In conclusion, we showed that ISO can antagonize Steroid-PAM both in α1β2γ2L and α4β3δ GABA-A receptor subtypes and inhibit estrus cycle-dependent aggressive behavior.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Bengtsson, Sara K. S.Umeå universitet,Obstetrik och gynekologi
(författare)
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Sjöstedt, JessicaUmeå universitet,Obstetrik och gynekologi
(författare)
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Malinina, EvgenyaUmeå universitet,Obstetrik och gynekologi(Swepub:umu)evma0003
(författare)
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Johansson, Inga-MajUmeå universitet,Obstetrik och gynekologi(Swepub:umu)injo0002
(författare)
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Ragagnin, GiannaUmeå universitet,Obstetrik och gynekologi(Swepub:umu)gira0002
(författare)
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Ekberg, KarinAsarina Pharma AB, Solna, Sweden
(författare)
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Lundgren, Per,1966-Umeå universitet,Obstetrik och gynekologi(Swepub:umu)pelu0003
(författare)
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Umeå universitetObstetrik och gynekologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Biomolecules: MDPI13:62218-273X
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