Sökning: onr:"swepub:oai:DiVA.org:umu-212103" > Mosaic chromosomal ...
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000 | 12801naa a2200901 4500 | |
001 | oai:DiVA.org:umu-212103 | |
003 | SwePub | |
008 | 230717s2023 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-2121032 URI |
024 | 7 | a https://doi.org/10.1016/j.jtho.2023.05.0012 DOI |
040 | a (SwePub)umu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Cheng, Chaou Institute for Clinical and Translational Research, Baylor College of Medicine, Texas, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Texas, Houston, United States; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Texas, Houston, United States4 aut |
245 | 1 0 | a Mosaic chromosomal alterations are associated with increased lung cancer risk :b insight from the INTEGRAL-ILCCO cohort analysis |
264 | 1 | b Elsevier,c 2023 |
338 | a print2 rdacarrier | |
520 | a Introduction: Mosaic chromosomal alterations (mCAs) detected in white blood cells represent a type of clonal hematopoiesis (CH) that is understudied compared with CH-related somatic mutations. A few recent studies indicated their potential link with nonhematological cancers, especially lung cancer. Methods: In this study, we investigated the association between mCAs and lung cancer using the high-density genotyping data from the OncoArray study of INTEGRAL-ILCCO, the largest single genetic study of lung cancer with 18,221 lung cancer cases and 14,825 cancer-free controls. Results: We identified a comprehensive list of autosomal mCAs, ChrX mCAs, and mosaic ChrY (mChrY) losses from these samples. Autosomal mCAs were detected in 4.3% of subjects, in addition to ChrX mCAs in 3.6% of females and mChrY losses in 9.6% of males. Multivariable logistic regression analysis indicated that the presence of autosomal mCAs in white blood cells was associated with an increased lung cancer risk after adjusting for key confounding factors, including age, sex, smoking status, and race. This association was mainly driven by a specific type of mCAs: copy-neutral loss of heterozygosity on autosomal chromosomes. The association between autosome copy-neutral loss of heterozygosity and increased risk of lung cancer was further confirmed in two major histologic subtypes, lung adenocarcinoma and squamous cell carcinoma. In addition, we observed a significant increase of ChrX mCAs and mChrY losses in smokers compared with nonsmokers and racial differences in certain types of mCA events. Conclusions: Our study established a link between mCAs in white blood cells and increased risk of lung cancer. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
653 | a Clonal hematopoiesis | |
653 | a Loss of heterozygosity | |
653 | a Lung cancer risk | |
653 | a Mosaic chromosomal alterations | |
700 | 1 | a Hong, Weiu Institute for Clinical and Translational Research, Baylor College of Medicine, Texas, Houston, United States4 aut |
700 | 1 | a Li, Yafangu Institute for Clinical and Translational Research, Baylor College of Medicine, Texas, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Texas, Houston, United States; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Texas, Houston, United States4 aut |
700 | 1 | a Xiao, Xiangjunu Institute for Clinical and Translational Research, Baylor College of Medicine, Texas, Houston, United States4 aut |
700 | 1 | a McKay, Jamesu Section of Genetics, International Agency for Research on Cancer, WHO, Lyon, France4 aut |
700 | 1 | a Han, Younghunu Institute for Clinical and Translational Research, Baylor College of Medicine, Texas, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Texas, Houston, United States4 aut |
700 | 1 | a Byun, Jinyoungu Institute for Clinical and Translational Research, Baylor College of Medicine, Texas, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Texas, Houston, United States4 aut |
700 | 1 | a Peng, Bou Institute for Clinical and Translational Research, Baylor College of Medicine, Texas, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Texas, Houston, United States4 aut |
700 | 1 | a Albanes, Demetriosu Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Maryland, Bethesda, United States4 aut |
700 | 1 | a Lam, Stephenu Department of Integrative Oncology, University of British Columbia, BC, Vancouver, Canada4 aut |
700 | 1 | a Tardon, Adoninau Public Health Department, University of Oviedo, ISPA and CIBERESP, Asturias, Spain4 aut |
700 | 1 | a Chen, Chuu Program in Epidemiology, Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States4 aut |
700 | 1 | a Bojesen, Stig E.u Department of Clinical Biochemistry, Copenhagen University Hospital, Copenhagen, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark4 aut |
700 | 1 | a Landi, Maria T.u Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Maryland, Bethesda, United States4 aut |
700 | 1 | a Johansson, Mattiasu Section of Genetics, International Agency for Research on Cancer, WHO, Lyon, France4 aut |
700 | 1 | a Risch, Angelau Thoraxklinik at University Hospital Heidelberg, Heidelberg, Germany; Translational Lung Research Center Heidelberg (TLRC-H), Heidelberg, Germany; University of Salzburg and Cancer Cluster Salzburg, Salzburg, Austria4 aut |
700 | 1 | a Bickeböller, Heikeu Department of Genetic Epidemiology, University Medical Center, Georg-August-University Göttingen, Göttingen, Germany4 aut |
700 | 1 | a Wichmann, H-Erichu Institute of Medical Statistics and Epidemiology, Technical University Munich, Munich, Germany4 aut |
700 | 1 | a Christiani, David C.u Department of Environmental Health, Harvard T.H. Chan School of Public Health, Massachusetts, Boston, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Massachusetts, Boston, United States4 aut |
700 | 1 | a Rennert, Gadu Clalit National Cancer Control Center at Carmel Medical Center and Technion Faculty of Medicine, Haifa, Israel4 aut |
700 | 1 | a Arnold, Susanneu University of Kentucky, Markey Cancer Center, Kentucky, Lexington, United States4 aut |
700 | 1 | a Goodman, Garyu Swedish Cancer Institute, WA, Seattle, United States4 aut |
700 | 1 | a Field, John K.u Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, United Kingdom4 aut |
700 | 1 | a Davies, Michael P.A.u Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, United Kingdom4 aut |
700 | 1 | a Shete, Sanjay S.u Department of Biostatistics, The University of Texas M. D. Anderson Cancer Center, Texas, Houston, United States; Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Texas, Houston, United States4 aut |
700 | 1 | a Le Marchand, Loicu Epidemiology Program, University of Hawaii Cancer Center, HI, Honolulu, United States4 aut |
700 | 1 | a Liu, Geoffreyu University Health Network- The Princess Margaret Cancer Centre, California, Toronto, United States4 aut |
700 | 1 | a Hung, Rayjean J.u Luenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Canada; Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Canada4 aut |
700 | 1 | a Andrew, Angeline S.u Department of Epidemiology, Dartmouth College, New Hampshire, Hanover, United States; Department of Community and Family Medicine, Dartmouth College, New Hampshire, Hanover, United States4 aut |
700 | 1 | a Kiemeney, Lambertus A.u Radboud University Medical Center, Nijmegen, Netherlands4 aut |
700 | 1 | a Zhu, Mengu Department of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing, China4 aut |
700 | 1 | a Shen, Hongbingu Department of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing, China4 aut |
700 | 1 | a Zienolddiny, Shanu National Institute of Occupational Health, Oslo, Norway4 aut |
700 | 1 | a Grankvist, Kjellu Umeå universitet,Institutionen för medicinsk biovetenskap4 aut0 (Swepub:umu)kjgr0002 |
700 | 1 | a Johansson, Mikaelu Umeå universitet,Institutionen för strålningsvetenskaper4 aut0 (Swepub:umu)mijo0025 |
700 | 1 | a Cox, Angelau Academic Unit of Clinical Oncology University of Sheffield, Weston Park Hospital, Whitham Road, Sheffield, United Kingdom4 aut |
700 | 1 | a Hong, Yun-Chulu Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, South Korea4 aut |
700 | 1 | a Yuan, Jian-Minu University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center, PA, Pittsburgh, United States4 aut |
700 | 1 | a Lazarus, Philipu Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, WA, Spokane, United States4 aut |
700 | 1 | a Schabath, Matthew B.u Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Florida, Tampa, United States4 aut |
700 | 1 | a Aldrich, Melinda C.u Department of Medicine, Vanderbilt University Medical Center, TN, Nashville, United States4 aut |
700 | 1 | a Brennan, Paulu Section of Genetics, International Agency for Research on Cancer, WHO, Lyon, France4 aut |
700 | 1 | a Li, Yongu Institute for Clinical and Translational Research, Baylor College of Medicine, Texas, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Texas, Houston, United States; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Texas, Houston, United States4 aut |
700 | 1 | a Gorlova, Olgau Institute for Clinical and Translational Research, Baylor College of Medicine, Texas, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Texas, Houston, United States; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Texas, Houston, United States4 aut |
700 | 1 | a Gorlov, Ivanu Institute for Clinical and Translational Research, Baylor College of Medicine, Texas, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Texas, Houston, United States; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Texas, Houston, United States4 aut |
700 | 1 | a Amos, Christopher I.u Institute for Clinical and Translational Research, Baylor College of Medicine, Texas, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Texas, Houston, United States; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Texas, Houston, United States4 aut |
710 | 2 | a Institute for Clinical and Translational Research, Baylor College of Medicine, Texas, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Texas, Houston, United States; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Texas, Houston, United Statesb Institute for Clinical and Translational Research, Baylor College of Medicine, Texas, Houston, United States4 org |
773 | 0 | t Journal of Thoracic Oncologyd : Elsevierg 18:8, s. 1003-1016q 18:8<1003-1016x 1556-0864x 1556-1380 |
856 | 4 | u https://doi.org/10.1016/j.jtho.2023.05.001y Fulltext |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-212103 |
856 | 4 8 | u https://doi.org/10.1016/j.jtho.2023.05.001 |
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