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Sökning: onr:"swepub:oai:DiVA.org:umu-214758" > Genome-wide interac...

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FältnamnIndikatorerMetadata
00020807naa a2201465 4500
001oai:DiVA.org:umu-214758
003SwePub
008231002s2023 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:155073743
024a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-2147582 URI
024a https://doi.org/10.1016/j.ajcnut.2023.08.0102 DOI
024a http://kipublications.ki.se/Default.aspx?queryparsed=id:1550737432 URI
040 a (SwePub)umud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
100a Bouras, Emmanouilu Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece4 aut
2451 0a Genome-wide interaction analysis of folate for colorectal cancer risk
264 1b Elsevier,c 2023
338 a electronic2 rdacarrier
520 a Background: Epidemiological and experimental evidence suggests that higher folate intake is associated with decreased colorectal cancer (CRC) risk; however, the mechanisms underlying this relationship are not fully understood. Genetic variation that may have a direct or indirect impact on folate metabolism can provide insights into folate's role in CRC.Objectives: Our aim was to perform a genome-wide interaction analysis to identify genetic variants that may modify the association of folate on CRC risk.Methods: We applied traditional case-control logistic regression, joint 3-degree of freedom, and a 2-step weighted hypothesis approach to test the interactions of common variants (allele frequency >1%) across the genome and dietary folate, folic acid supplement use, and total folate in relation to risk of CRC in 30,550 cases and 42,336 controls from 51 studies from 3 genetic consortia (CCFR, CORECT, GECCO).Results: Inverse associations of dietary, total folate, and folic acid supplement with CRC were found (odds ratio [OR]: 0.93; 95% confidence interval [CI]: 0.90, 0.96; and 0.91; 95% CI: 0.89, 0.94 per quartile higher intake, and 0.82 (95% CI: 0.78, 0.88) for users compared with nonusers, respectively). Interactions (P-interaction < 5×10-8) of folic acid supplement and variants in the 3p25.2 locus (in the region of Synapsin II [SYN2]/tissue inhibitor of metalloproteinase 4 [TIMP4]) were found using traditional interaction analysis, with variant rs150924902 (located upstream to SYN2) showing the strongest interaction. In stratified analyses by rs150924902 genotypes, folate supplementation was associated with decreased CRC risk among those carrying the TT genotype (OR: 0.82; 95% CI: 0.79, 0.86) but increased CRC risk among those carrying the TA genotype (OR: 1.63; 95% CI: 1.29, 2.05), suggesting a qualitative interaction (P-interaction = 1.4×10-8). No interactions were observed for dietary and total folate.Conclusions: Variation in 3p25.2 locus may modify the association of folate supplement with CRC risk. Experimental studies and studies incorporating other relevant omics data are warranted to validate this finding.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653 a colorectal cancer
653 a CRC
653 a European
653 a folate
653 a folic acid
653 a genome-wide
653 a GWIS
653 a interaction
653 a SYN2
653 a synapsin
653 a TIMP4
653 a tissue inhibitor of metalloproteinase 4
700a Kim, Andre E.u Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States4 aut
700a Lin, Yiu Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States4 aut
700a Morrison, Johnu Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States4 aut
700a Du, Mengmengu Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, NY, New York, United States4 aut
700a Albanes, Demetriusu Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States4 aut
700a Barry, Elizabeth L.u Department of Epidemiology, Geisel School of Medicine at Dartmouth, NH, Hanover, United States4 aut
700a Baurley, James W.u Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia; BioRealm LLC, CA, Walnut, United States4 aut
700a Berndt, Sonja I.u Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, MD, Bethesda, United States4 aut
700a Bien, Stephanie A.u Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States4 aut
700a Bishop, Timothy D.u Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, United Kingdom4 aut
700a Brenner, Hermannu Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany4 aut
700a Budiarto, Arifu Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia; Computer Science Department, School of Computer Science, Bina Nusantara University, Jakarta, Indonesia4 aut
700a Burnett-Hartman, Andreau Institute for Health Research, Kaiser Permanente Colorado, CO, Denver, United States4 aut
700a Campbell, Peter T.u Department of Epidemiology and Population Health, Albert Einstein College of Medicine, NY, Bronx, United States4 aut
700a Carreras-Torres, Robertu Unit of Biomarkers and Suceptibility (UBS), Oncology Data Analytics Program (ODAP), Catalan Institute of Oncology (ICO), L'Hospitalet del Llobregat, Barcelona, Spain; ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Digestive Diseases and Microbiota Group, Girona Biomedical Research Institute (IDIBGI), Salt, Girona, Spain4 aut
700a Casey, Grahamu Center for Public Health Genomics, University of Virginia, VA, Charlottesville, United States4 aut
700a Cenggoro, Tjeng Wawanu Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia; Computer Science Department, School of Computer Science, Bina Nusantara University, Jakarta, Indonesia4 aut
700a Chan, Andrew T.u Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, MA, Boston, United States; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Broad Institute of Harvard and MIT, MA, Cambridge, United States; Department of Epidemiology, Harvard TH Chan School of Public Health, Harvard University, MA, Boston, United States; Department of Immunology and Infectious Diseases, Harvard TH Chan School of Public Health, Harvard University, MA, Boston, United States4 aut
700a Chang-Claude, Jennyu Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; University Medical Centre Hamburg-Eppendorf, University Cancer Centre Hamburg (UCCH), Hamburg, Germany4 aut
700a Conti, David V.u Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States4 aut
700a Cotterchio, Michelleu Ontario Health (Cancer Care Ontario), ON, Toronto, Canada4 aut
700a Devall, Matthewu Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, VA, Charlottesville, United States; Department of Public Health Sciences, Center for Public Health Genomics, VA, Charlottesville, United States4 aut
700a Diez-Obrero, Virginiau Unit of Biomarkers and Suceptibility (UBS), Oncology Data Analytics Program (ODAP), Catalan Institute of Oncology (ICO), L'Hospitalet del Llobregat, Barcelona, Spain; ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain4 aut
700a Dimou, Nikiu Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France4 aut
700a Drew, David A.u Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States4 aut
700a Figueiredo, Jane C.u Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, CA, Los Angeles, United States4 aut
700a Giles, Graham G.u Cancer Epidemiology Division, Cancer Council Victoria, VIC, Melbourne, Australia; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, VIC, Melbourne, Australia; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, VIC, Clayton, Australia4 aut
700a Gruber, Stephen B.u Department of Medical Oncology & Therapeutics Research, City of Hope National Medical Center, CA, Duarte, United States4 aut
700a Gunter, Marc J.u Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France4 aut
700a Harrison, Tabitha A.u Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States4 aut
700a Hidaka, Akihisau Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States4 aut
700a Hoffmeister, Michaelu Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany4 aut
700a Huyghe, Jeroen R.u Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States4 aut
700a Joshi, Amit D.u Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, MA, Boston, United States; Department of Epidemiology, Harvard TH Chan School of Public Health, Harvard University, MA, Boston, United States4 aut
700a Kawaguchi, Eric S.u Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States; Department of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, CA, Los Angeles, United States4 aut
700a Keku, Temitope O.u Center for Gastrointestinal Biology and Disease, University of North Carolina, NC, Chapel Hill, United States4 aut
700a Kundaje, Anshulu Department of Genetics, Stanford University, CA, Stanford, United States; Department of Computer Science, Stanford University, CA, Stanford, United States4 aut
700a Le Marchand, Loicu University of Hawaii Cancer Center, HI, Honolulu, United States4 aut
700a Lewinger, Juan Pablou Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States4 aut
700a Li, Liu Department of Family Medicine, University of Virginia, VA, Charlottesville, United States4 aut
700a Lynch, Brigid M.u Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, VIC, Melbourne, Australia; Cancer Epidemiology Division, Cancer Council Victoria, VIC, Melbourne, Australia4 aut
700a Mahesworo, Bharunou Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia4 aut
700a Männistö, Satuu Department of Public Health Solutions, National Institute for Health and Welfare, Helsinki, Finland4 aut
700a Moreno, Victoru Unit of Biomarkers and Suceptibility (UBS), Oncology Data Analytics Program (ODAP), Catalan Institute of Oncology (ICO), L'Hospitalet del Llobregat, Barcelona, Spain; ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain; Department of Clinical Sciences, Faculty of Medicine and health Sciences and Universitat de Barcelona Institute of Complex Systems (UBICS), University of Barcelona (UB), L'Hospitalet de Llobregat, Barcelona, Spain4 aut
700a Murphy, Neilu Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France4 aut
700a Newcomb, Polly A.u Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States; School of Public Health, University of Washington, WA, Seattle, United States4 aut
700a Obón-Santacana, Mireiau Unit of Biomarkers and Suceptibility (UBS), Oncology Data Analytics Program (ODAP), Catalan Institute of Oncology (ICO), L'Hospitalet del Llobregat, Barcelona, Spain; ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain4 aut
700a Ose, Jenniferu Huntsman Cancer Institute, University of Utah, Utah, Salt Lake City, United States; Department of Population Health Sciences, University of Utah, UT, Salt Lake City, United States4 aut
700a Palmer, Julie R.u Slone Epidemiology Center at Boston University, MA, Boston, United States4 aut
700a Papadimitriou, Nikosu Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France4 aut
700a Pardamean, Bensu Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia4 aut
700a Pellatt, Andrew J.u Department of Cancer Medicine, MD Anderson Cancer Center, TX, Houston, United States4 aut
700a Peoples, Anita R.u Huntsman Cancer Institute, University of Utah, Utah, Salt Lake City, United States; Department of Population Health Sciences, University of Utah, UT, Salt Lake City, United States4 aut
700a Platz, Elizabeth A.u Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, MD, Baltimore, United States4 aut
700a Potter, John D.u Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States; Research Centre for Hauora and Health, Massey University, Wellington, New Zealand4 aut
700a Qi, Lihongu Department of Public Health Sciences, University of California Davis, CA, Davis, United States4 aut
700a Qu, Conghuiu Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States4 aut
700a Rennert, Gadu Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel; Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel; Clalit National Cancer Control Center, Haifa, Israel4 aut
700a Ruiz-Narvaez, Edwardu Department of Nutritional Sciences, University of Michigan School of Public Health, MI, Ann Arbor, United States4 aut
700a Sakoda, Lori C.u Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States; Division of Research, Kaiser Permanente Northern California, CA, Oakland, United States4 aut
700a Schmit, Stephanie L.u Genomic Medicine Institute, Cleveland Clinic, OH, Cleveland, United States; Population and Cancer Prevention Program, Case Comprehensive Cancer Center, OH, Cleveland, United States4 aut
700a Shcherbina, Annau Department of Genetics, Stanford University, CA, Stanford, United States; Department of Computer Science, Stanford University, CA, Stanford, United States4 aut
700a Stern, Mariana C.u Department of Population and Public Health Sciences and Norris Comprehensive Cancer Center, Preventive Medicine, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States4 aut
700a Su, Yu-Ruu Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States4 aut
700a Tangen, Catherine M.u SWOG Statistical Center, Fred Hutchinson Cancer Research Center, WA, Seattle, United States4 aut
700a Thomas, Duncan C.u Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States4 aut
700a Tian, Yuu Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; School of Public Health, Capital Medical University, Beijing, China4 aut
700a Um, Caroline Y.u Department of Population Science, American Cancer Society, GA, Atlanta, United States4 aut
700a van Duijnhoven, Franzel JB.u Division of Human Nutrition and Health, Wageningen University & Research, Wageningen, Netherlands4 aut
700a van Guelpen, Bethanyu Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Onkologi4 aut0 (Swepub:umu)beyvan99
700a Visvanathan, Kalau Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, MD, Baltimore, United States4 aut
700a Wang, Junu Department of Population and Public Health Sciences and Norris Comprehensive Cancer Center, Preventive Medicine, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States4 aut
700a White, Emilyu Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States; Department of Epidemiology, University of Washington School of Public Health, WA, Seattle, United States4 aut
700a Wolk, Alicjau Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden4 aut
700a Woods, Michael O.u Memorial University of Newfoundland, Discipline of Genetics, St John's, Canada4 aut
700a Ulrich, Cornelia M.u Huntsman Cancer Institute, University of Utah, Utah, Salt Lake City, United States; Department of Population Health Sciences, University of Utah, UT, Salt Lake City, United States4 aut
700a Hsu, Liu Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States; Department of Biostatistics, University of Washington, WA, Seattle, United States4 aut
700a Gauderman, W Jamesu Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States4 aut
700a Peters, Ulrikeu Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States; Department of Epidemiology, University of Washington, WA, Seattle, United States4 aut
700a Tsilidis, Konstantinos K.u Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece; Department of Epidemiology and Biostatistics, Imperial College London, School of Public Health, London, United Kingdom4 aut
710a Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greeceb Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, CA, Los Angeles, United States4 org
773t American Journal of Clinical Nutritiond : Elsevierg 118:5, s. 881-891q 118:5<881-891x 0002-9165x 1938-3207
856u https://doi.org/10.1016/j.ajcnut.2023.08.010y Fulltext
856u https://umu.diva-portal.org/smash/get/diva2:1801512/FULLTEXT02.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-214758
8564 8u https://doi.org/10.1016/j.ajcnut.2023.08.010
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:155073743

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Devall, Matthew
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Dimou, Niki
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