Sökning: onr:"swepub:oai:DiVA.org:umu-215011" >
The mitochondrial n...
The mitochondrial network in Parkinson's disease
-
Kohler, Andreas, 1988- (författare)
-
- Kohler, Verena, 1992- (författare)
- Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden
-
Büttner, Sabrina (författare)
-
(creator_code:org_t)
- Academic Press, 2020
- 2020
- Engelska.
-
Ingår i: Genetics, neurology, behavior, and diet in parkinson's disease. - : Academic Press. - 9780128159507 ; , s. 123-138
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Neuronal dysfunction during sporadic and familial forms of Parkinson’s disease is intimately connected to mitochondrial dysfunction. Diverse genetic and environmental factors contributing to Parkinson’s disease development and progression have been shown to interfere with and to compromise mitochondrial bioenergetics, dynamics and trafficking. Mitochondria are highly dynamic organelles, constantly changing shape and abundance via coordinated fission and fusion events to adapt to cellular needs. Moreover, direct contact between mitochondria and other organelles allows interconnected signaling, and exchange of metabolites and ions. Several proteins associated with familial Parkinson’s disease modulate the equilibrium between fission and fusion, govern distinct mitochondrial degradation pathways and impact the formation of tethering complexes that facilitate interorganellar contact. Here, we discuss molecular mechanisms of mitochondrial dysfunction in Parkinson’s disease, focusing on mitochondrial dynamics and contact sites.
Ämnesord
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- Interorganellar contact sites
- Mitochondria
- Mitochondria-associated membranes
- Mitochondria-lysosome contacts
- Mitochondrial biogenesis
- Mitochondrial degradation
- Mitochondrial dynamics
- Mitochondrial quality control
- Mitochondrial transport
- Parkinson’s disease
Publikations- och innehållstyp
- ref (ämneskategori)
- kap (ämneskategori)
Hitta via bibliotek
Till lärosätets databas