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Altered plasma meta...
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Löding, SebastianDepartment of Chemistry
(författare)
Altered plasma metabolite levels can be detected years before a glioma diagnosis
- Artikel/kapitelEngelska2023
Förlag, utgivningsår, omfång ...
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American Society For Clinical Investigation,2023
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:umu-215372
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-215372URI
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https://doi.org/10.1172/jci.insight.171225DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Genetic and metabolic changes in tissue and blood are reported to occur several years before glioma diagnosis. Since gliomas are currently detected late, a liquid biopsy for early detection could affect the quality of life and prognosis of patients. Here, we present a nested case-control study of 550 prediagnostic glioma cases and 550 healthy controls from the Northern Sweden Health and Disease study (NSHDS) and the European Prospective Investigation into Cancer and Nutrition (EPIC) study. We identified 93 significantly altered metabolites related to glioma development up to 8 years before diagnosis. Out of these metabolites, a panel of 20 selected metabolites showed strong disease correlation and a consistent progression pattern toward diagnosis in both the NSHDS and EPIC cohorts, and they separated future cases from controls independently of biological sex. The blood metabolite panel also successfully separated both lower-grade glioma and glioblastoma cases from controls, up to 8 years before diagnosis in patients within the NSHDS cohort and up to 2 years before diagnosis in EPIC. Pathway enrichment analysis detected metabolites related to the TCA cycle, Warburg effect, gluconeogenesis, and cysteine, pyruvate, and tyrosine metabolism as the most affected.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Andersson, UlrikaUmeå universitet,Onkologi,Biobank Reserach Unit(Swepub:umu)ulan0002
(författare)
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Kaaks, RudolfDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
(författare)
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Schulze, Matthias B.Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany
(författare)
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Pala, ValeriaEpidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
(författare)
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Urbarova, IlonaDepartment of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway
(författare)
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Amiano, PilarCIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Ministry of Health of the Basque Government, Public Health Laboratory in Gipuzkoa, San Sebastián, Spain; Epidemiology of Chronic and Comunnicable Diseases Area, Biodonostia Health Research Institute, San Sebastián, Spain
(författare)
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Colorado-Yohar, Sandra M.CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Department of Epidemiology, Murcia Regional Health Council, IMIB, Murcia, Spain; Research Group on Demography and Health, National Faculty of Public Health, University of Antioquia, Medellín, Colombia
(författare)
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Guevara, MarcelaCIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Institute of Public and Labor Health and Navarra, Pamplona, Spain; Navarra Institute for Health Research (IdiSNA), Pamplona, Spain
(författare)
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Heath, Alicia K.Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
(författare)
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Chatziioannou, Anastasia ChrysovalantouNutrition and Metabolism Branch, International Agency for Research on Cancer (IARC), Lyon, France
(författare)
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Johansson, MattiasGenomic Epidemiology Branch, IARC, Lyon, France
(författare)
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Nyberg, Lars,1966-Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB),Diagnostisk radiologi(Swepub:umu)lany0001
(författare)
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Antti, HenrikDepartment of Chemistry
(författare)
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Björkblom, BennyDepartment of Chemistry
(författare)
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Melin, Beatrice S.Umeå universitet,Onkologi(Swepub:umu)bema0010
(författare)
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Department of ChemistryOnkologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:JCI Insight: American Society For Clinical Investigation8:192379-3708
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Löding, Sebastia ...
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Andersson, Ulrik ...
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Kaaks, Rudolf
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Schulze, Matthia ...
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Pala, Valeria
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Urbarova, Ilona
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Amiano, Pilar
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Colorado-Yohar, ...
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Guevara, Marcela
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Heath, Alicia K.
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Chatziioannou, A ...
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Johansson, Matti ...
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Nyberg, Lars, 19 ...
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Antti, Henrik
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Björkblom, Benny
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Melin, Beatrice ...
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