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Comorbidities in ch...
Comorbidities in childhood atopic dermatitis : a population-based study
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- von Kobyletzki, Laura (författare)
- Lund University,Lunds universitet,Yrkes- och miljödermatologi,Forskargrupper vid Lunds universitet,Occupational and Environmental Dermatology,Lund University Research Groups,Skåne University Hospital,Lund Univ, Skane Univ Hosp, Dept Occupat & Environm Dermatol, Lund, Sweden.
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- Henrohn, Dan (författare)
- Uppsala universitet,Uppsala University,Pfizer AB, Inflammat & Immunol, Stockholm, Sweden.,Kardiologi
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- Ballardini, Natalia (författare)
- Karolinska Institute,Karolinska Institutet,Stockholm South General Hospital,Karolinska Inst, Inst Environm Med, Stockholm, Sweden.;Soder Sjukhuset, Dept Dermatol & Sexual Hlth, Stockholm, Sweden.;Soder Sjukhuset, Karolinska Inst, Dept Clin Sci & Educ, Stockholm, Sweden.
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- Neary, Maureen P. (författare)
- Inflammation and Immunology, Pfizer Inc., PA, Collegeville, United States,Pfizer Inc, Inflammat & Immunol, Collegeville, PA USA.
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- Ortsäter, Gustaf (författare)
- Quantify Research AB, Stockholm, Sweden,Quantify Res AB, Stockholm, Sweden.;Quantify Res AB, Stockholm, Sweden.
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- Rieem Dun, Alexander (författare)
- Quantify Research AB, Stockholm, Sweden,Quantify Res AB, Stockholm, Sweden.
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- Geale, Kirk (författare)
- Umeå University,Umeå universitet,Dermatologi och venereologi,Quantify Research AB, Stockholm, Sweden,Quantify Res AB, Stockholm, Sweden.;Umeå Univ, Dept Publ Hlth & Clin Med, Dermatol & Venereol, Umeå, Sweden.
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- Lindberg, Ingrid (författare)
- Quantify Research AB, Stockholm, Sweden,Quantify Res AB, Stockholm, Sweden.
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- Theodosiou, Grigorios (författare)
- Department of Dermatology, Skåne University Hospital, Malmö, Sweden,Skane Univ Hosp, Dept Dermatol, Malmö, Sweden.
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- Neregård, Petra (författare)
- Inflammation and Immunology, Pfizer AB, Stockholm, Sweden,Pfizer AB, Inflammat & Immunol, Stockholm, Sweden.
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- De Geer, Anna (författare)
- Inflammation and Immunology, Pfizer AB, Stockholm, Sweden,Pfizer AB, Inflammat & Immunol, Stockholm, Sweden.
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- Cha, Amy (författare)
- Inflammation and Immunology, Pfizer Inc., NY, New York, United States,Pfizer Inc, Inflammat & Immunol, New York, NY USA.
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- Cappelleri, Joseph C. (författare)
- Global Biometrics and Data Management (Statistics), Pfizer Inc., CT, Groton, United States,Pfizer Inc, Global Biometr & Data Management Stat, Groton, CT USA.
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- Thyssen, Jacob P. (författare)
- Department of Dermatology and Venereology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark,Univ Copenhagen, Bispebjerg Hosp, Dept Dermatol & Venereol, Copenhagen, Denmark.
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(creator_code:org_t)
- John Wiley & Sons, 2024
- 2024
- Engelska.
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Ingår i: Journal of the European Academy of Dermatology and Venereology. - : John Wiley & Sons. - 0926-9959 .- 1468-3083. ; 38:2, s. 354-364
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https://urn.kb.se/re...
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Abstract
Ämnesord
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- Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease that is associated with allergic comorbidities. However, studies examining comorbidities in childhood AD are incomplete, which may contribute to suboptimal care.Objective: The objective was to compare the risk of developing different allergic and non-allergic comorbidities among children with AD to that of a matched non-AD reference cohort in Sweden.Methods: This was a nationwide population-based cohort study using longitudinal data from primary and specialist care registers. Patients with AD were identified by confirmed diagnosis in primary or specialist care. The non-AD reference cohort was randomly drawn from the general population and matched 1:1 with the AD patients. The risk of developing the following conditions was evaluated: hypersensitivity and allergic disorders, neurological disorders, psychiatric disorders, infections, immunological and inflammatory disorders, Type 1 diabetes (T1D), endocrine and metabolic disorders, skeletal disorders, ocular disorders and malignancies.Results: This study included 165,145 patients with AD (mild-to-moderate [n = 126,681] and severe [n = 38,464]) and an equally sized reference cohort. Patients with AD displayed a higher risk of developing comorbid conditions for all investigated categories, except for T1D and skeletal disorders, compared with the reference cohort. The highest risk compared with the reference cohort was observed for hypersensitivity and allergic disorders (hazard ratio [HR]: 3.87), followed by malignancies (HR: 2.53) and immunological and inflammatory disorders (HR: 2.36). Patients with AD also had higher risk of developing multiple comorbidities (≥2). The risk of comorbidity onset increased alongside AD severity and patients with active AD were associated with increased risk of comorbidity onset compared with patients in remission.Conclusions: The clinical burden of AD is substantial for children with AD and patients are at an increased risk of developing several comorbid conditions extending beyond the atopic march. Our results also showed a positive association between worsening severity of AD and an increased risk of comorbidity onset.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Dermatologi och venereologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dermatology and Venereal Diseases (hsv//eng)
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von Kobyletzki, ...
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Henrohn, Dan
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Ballardini, Nata ...
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Neary, Maureen P ...
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Ortsäter, Gustaf
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Rieem Dun, Alexa ...
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Geale, Kirk
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Lindberg, Ingrid
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Theodosiou, Grig ...
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Neregård, Petra
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De Geer, Anna
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Cha, Amy
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Cappelleri, Jose ...
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Thyssen, Jacob P ...
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och Klinisk medicin
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Umeå universitet
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Karolinska Institutet
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Lunds universitet
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Uppsala universitet