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Sökning: onr:"swepub:oai:DiVA.org:umu-216651" > Inducin triggers LC...

Inducin triggers LC3-lipidation and ESCRT-mediated lysosomal membrane repair

Corkery, Dale (författare)
Umeå universitet,Kemiska institutionen,Umeå Centre for Microbial Research (UCMR)
Ursu, Andrei (författare)
Department of Chemical Biology, Max Planck Institute of Molecular Physiology, Otto-Hahn-Strasse 11, Dortmund, Germany
Lucas, Belén (författare)
Department of Chemical Biology, Max Planck Institute of Molecular Physiology, Otto-Hahn-Strasse 11, Dortmund, Germany
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Grigalunas, Michael (författare)
Department of Chemical Biology, Max Planck Institute of Molecular Physiology, Otto-Hahn-Strasse 11, Dortmund, Germany
Kriegler, Simon (författare)
Physical Chemistry I – Biophysical Chemistry, Department of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Strasse 4a, 44227 Dortmund, Germany, Germany
Oliva, Rosario (författare)
Physical Chemistry I – Biophysical Chemistry, Department of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Strasse 4a, 44227 Dortmund, Germany, Germany; Department of Chemical Sciences, University of Naples Federico II, Via Cintia 4, Naples, Italy
Dec, Robert (författare)
Physical Chemistry I – Biophysical Chemistry, Department of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Strasse 4a, 44227 Dortmund, Germany, Germany
Koska, Sandra (författare)
Department of Chemical Biology, Max Planck Institute of Molecular Physiology, Otto-Hahn-Strasse 11, Dortmund, Germany
Pahl, Axel (författare)
Department of Chemical Biology, Max Planck Institute of Molecular Physiology, Otto-Hahn-Strasse 11, Dortmund, Germany
Sievers, Sonja (författare)
Department of Chemical Biology, Max Planck Institute of Molecular Physiology, Otto-Hahn-Strasse 11, Dortmund, Germany
Ziegler, Slava (författare)
Department of Chemical Biology, Max Planck Institute of Molecular Physiology, Otto-Hahn-Strasse 11, Dortmund, Germany
Winter, Roland (författare)
Physical Chemistry I – Biophysical Chemistry, Department of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Strasse 4a, 44227 Dortmund, Germany, Germany
Wu, Yao-Wen, Professor (författare)
Umeå universitet,Kemiska institutionen,Umeå Centre for Microbial Research (UCMR)
Waldmann, Herbert (författare)
Department of Chemical Biology, Max Planck Institute of Molecular Physiology, Otto-Hahn-Strasse 11, Dortmund, Germany; Faculty of Chemistry and Chemical Biology, Technical University Dortmund, Otto-Hahn-Strasse 6, Dortmund, Germany
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 (creator_code:org_t)
Wiley-VCH Verlagsgesellschaft, 2023
2023
Engelska.
Ingår i: ChemBioChem. - : Wiley-VCH Verlagsgesellschaft. - 1439-4227 .- 1439-7633. ; 24:24
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Lipidation of the LC3 protein has frequently been employed as a marker of autophagy. However, LC3-lipidation is also triggered by stimuli not related to canonical autophagy. Therefore, characterization of the driving parameters for LC3 lipidation is crucial to understanding the biological roles of LC3. We identified a pseudo-natural product, termed Inducin, that increases LC3 lipidation independently of canonical autophagy, impairs lysosomal function and rapidly recruits Galectin 3 to lysosomes. Inducin treatment promotes Endosomal Sorting Complex Required for Transport (ESCRT)-dependent membrane repair and transcription factor EB (TFEB)-dependent lysosome biogenesis ultimately leading to cell death.

Ämnesord

NATURVETENSKAP  -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)

Nyckelord

biological activity
endolysosomal membrane damage
LC3 lipidation
lysosomal membrane permeabilization
small molecule

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