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Omics signatures li...
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Schillemans, TessaKarolinska Institute,Karolinska Institutet,Karolinska Inst, Inst Environm Med, Cardiovasc & Nutr Epidemiol, S-17177 Stockholm, Sweden.
(författare)
Omics signatures linking persistent organic pollutants to cardiovascular disease in the Swedish mammography cohort
- Artikel/kapitelEngelska2024
Förlag, utgivningsår, omfång ...
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American Chemical Society (ACS),2024
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:umu-220017
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-220017URI
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https://doi.org/10.1021/acs.est.3c06388DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:154694353URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-522288URI
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https://research.chalmers.se/publication/539530URI
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https://lup.lub.lu.se/record/a0b5d8cf-5084-47c5-9ad3-bfa84e1c52daURI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Cardiovascular disease (CVD) development may be linked to persistent organic pollutants (POPs), including organochlorine compounds (OCs) and perfluoroalkyl and polyfluoroalkyl substances (PFAS). To explore underlying mechanisms, we investigated metabolites, proteins, and genes linking POPs with CVD risk. We used data from a nested case-control study on myocardial infarction (MI) and stroke from the Swedish Mammography Cohort - Clinical (n = 657 subjects). OCs, PFAS, and multiomics (9511 liquid chromatography-mass spectrometry (LC-MS) metabolite features; 248 proteins; 8110 gene variants) were measured in baseline plasma. POP-related omics features were selected using random forest followed by Spearman correlation adjusted for confounders. From these, CVD-related omics features were selected using conditional logistic regression. Finally, 29 (for OCs) and 12 (for PFAS) unique features associated with POPs and CVD. One omics subpattern, driven by lipids and inflammatory proteins, associated with MI (OR = 2.03; 95% CI = 1.47; 2.79), OCs, age, and BMI, and correlated negatively with PFAS. Another subpattern, driven by carnitines, associated with stroke (OR = 1.55; 95% CI = 1.16; 2.09), OCs, and age, but not with PFAS. This may imply that OCs and PFAS associate with different omics patterns with opposite effects on CVD risk, but more research is needed to disentangle potential modifications by other factors.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Yan, Yingxiao,1997Chalmers University of Technology(Swepub:cth)yingxiao
(författare)
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Ribbenstedt, Anton,1986Chalmers University of Technology(Swepub:cth)antonri
(författare)
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Donat-Vargas, CarolinaKarolinska Institute,Centre for Research in Environmental Epidemiology
(författare)
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Lindh, Christian H.Lund University,Lunds universitet,Tillämpad masspektrometri inom miljömedicin,Forskargrupper vid Lunds universitet,Applied Mass Spectrometry in Environmental Medicine,Lund University Research Groups(Swepub:lu)ymed-cli
(författare)
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Kiviranta, HannuDepartment of Health Security, National Institute for Health and Welfare, Kuopio, Finland,Natl Inst Hlth & Welf, Dept Hlth Secur, Kuopio 70701, Finland.,National Institute for Health and Welfare,Finnish National Institute for Health and Welfare
(författare)
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Rantakokko, PanuDepartment of Health Security, National Institute for Health and Welfare, Kuopio, Finland,Natl Inst Hlth & Welf, Dept Hlth Secur, Kuopio 70701, Finland.,National Institute for Health and Welfare,Finnish National Institute for Health and Welfare
(författare)
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Wolk, AlicjaKarolinska Institute,Karolinska Institutet,Karolinska Inst, Inst Environm Med, Cardiovasc & Nutr Epidemiol, S-17177 Stockholm, Sweden.
(författare)
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Landberg, RikardUmeå universitet,Institutionen för folkhälsa och klinisk medicin,Food and Nutrition Sciences, Department of Life Sciences, Chalmers University of Technology, Gothenburg, Sweden,Chalmers Univ Technol, Dept Life Sci, Food & Nutr Sci, S-41296 Gothenburg, Sweden.;Umeå Univ, Dept Publ Hlth & Clin Med, S-90187 Umeå, Sweden.,Chalmers tekniska högskola,Chalmers University of Technology,Umeå University(Swepub:cth)riklan
(författare)
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Åkesson, AgnetaKarolinska Institute,Karolinska Institutet,Karolinska Inst, Inst Environm Med, Cardiovasc & Nutr Epidemiol, S-17177 Stockholm, Sweden.
(författare)
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Brunius, CarlUppsala universitet,Medicinsk epidemiologi,Chalmers Univ Technol, Dept Life Sci, Food & Nutr Sci, S-41296 Gothenburg, Sweden; Chalmers Univ Technol, Dept Life Sci, Chalmers Mass Spectrometry Infrastruct, S-41296 Gothenburg, Sweden,Uppsala University,Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)carlbru
(författare)
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Karolinska InstitutetKarolinska Inst, Inst Environm Med, Cardiovasc & Nutr Epidemiol, S-17177 Stockholm, Sweden.
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Environmental Science and Technology: American Chemical Society (ACS)58:2, s. 1036-10470013-936X1520-5851
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Schillemans, Tes ...
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Yan, Yingxiao, 1 ...
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Ribbenstedt, Ant ...
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Donat-Vargas, Ca ...
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Lindh, Christian ...
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Kiviranta, Hannu
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Rantakokko, Panu
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Wolk, Alicja
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Landberg, Rikard
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Åkesson, Agneta
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Brunius, Carl
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