Sökning: onr:"swepub:oai:DiVA.org:umu-220858" > Cichorium intybus L...
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000 | 04914naa a2200481 4500 | |
001 | oai:DiVA.org:umu-220858 | |
003 | SwePub | |
008 | 240219s2023 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-2208582 URI |
024 | 7 | a https://doi.org/10.1016/j.heliyon.2023.e220552 DOI |
040 | a (SwePub)umu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Hussain, Nadiau Department of Pharmaceutical Sciences, College of Pharmacy, Al Ain University, Al Ain, United Arab Emirates4 aut |
245 | 1 0 | a Cichorium intybus L. significantly alleviates cigarette smoke-induced acute lung injury by lowering NF-κB pathway activation and inflammatory mediators |
264 | 1 | b Elsevier,c 2023 |
338 | a electronic2 rdacarrier | |
520 | a Background: Cigarette smoke (CS) is one of the primary causes of acute lung injury (ALI) via provoking pulmonary inflammation and oxidative stress. Despite substantial studies, no effective treatment for ALI is presently available.Purpose: New prospective treatment options for ALI are required. Thus, this project was designed to investigate the in vivo and in vitro protective effects of 70 % methanolic-aqueous crude extract of whole plant of Cichorium intybus (Ci.Mce) against CS-induced ALI.Study design: /methods: Initially, male Swiss albino mice were subjected to whole-body CS exposure for 10 continuous days to prepare CS-induced ALI models. Normal saline (10 mL/kg), Ci.Mce (100, 200, 300 mg/kg), and Dexamethasone (1 mg/kg) were orally administered to respective animal groups 1 h prior to CS-exposure. 24 hrs after the last CS-exposure, BALF and lungs were harvested to study the key characteristics of ALI. Next, HPLC analysis was done to explore the phytoconstituents.Results: Ci.Mce exhibited significant reductions in lung macrophage and neutrophil infiltration, lung weight coefficient, and albumin exudation. Additionally, it effectively ameliorated lung histopathological alterations and hypoxemia. Notably, Ci.Mce exerted inhibitory effects on the excessive generation of IL-6, IL-1β, and KC in both CS-induced ALI murine models and CSE-stimulated RAW 264.7 macrophages. Noteworthy benefits included the attenuation of oxidative stress induced by CS, evidenced by decreased levels of MDA, TOS, and MPO, alongside enhanced TAC production. Furthermore, Ci.Mce demonstrated a marked reduction in CS-induced NF-κB expression, both in vivo and in vitro.Conclusion: Consequently, Cichorium intybus could be a therapeutic option for CS-induced ALI due to its ability to suppress inflammatory reactions, mitigate oxidative stress, and quell NF-κB p65 activation. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Farmakologi och toxikologi0 (SwePub)301022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Pharmacology and Toxicology0 (SwePub)301022 hsv//eng |
653 | a ALI | |
653 | a IL-1β | |
653 | a IL-6 | |
653 | a MPO | |
653 | a NF-κB p65 | |
653 | a TOS | |
700 | 1 | a Ikram, Nadiau Faculty of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, Pakistan4 aut |
700 | 1 | a Khan, Kashif ur Rehmanu Faculty of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, Pakistan4 aut |
700 | 1 | a Hussain, Liaqatu Department of Pharmacology, Government College University, Faisalabad, Pakistan4 aut |
700 | 1 | a Alqahtani, Ali M.u Department of Pharmacology, College of Pharmacy, King Khalid University, Abha, Saudi Arabia4 aut |
700 | 1 | a Alqahtani, Tahau Department of Pharmacology, College of Pharmacy, King Khalid University, Abha, Saudi Arabia4 aut |
700 | 1 | a Hussain, Musaddiqueu Faculty of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, Pakistan4 aut |
700 | 1 | a Suliman, Muathu Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, P.O. Box 61413, Abha, Saudi Arabia4 aut |
700 | 1 | a Alshahrani, Mohammad Y.u Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, P.O. Box 61413, Abha, Saudi Arabia4 aut |
700 | 1 | a Sitohy, Baselu Umeå universitet,Onkologi,Klinisk immunologi4 aut0 (Swepub:umu)balsiy01 |
710 | 2 | a Department of Pharmaceutical Sciences, College of Pharmacy, Al Ain University, Al Ain, United Arab Emiratesb Faculty of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, Pakistan4 org |
773 | 0 | t Heliyond : Elsevierg 9:11q 9:11x 2405-8440 |
856 | 4 | u https://doi.org/10.1016/j.heliyon.2023.e22055y Fulltext |
856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:1838843/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-220858 |
856 | 4 8 | u https://doi.org/10.1016/j.heliyon.2023.e22055 |
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