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Organo-ptii complex...
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Chong, HuiDepartment of Chemical and Chemical Engineering, Yangzhou University, No. 180, Si-Wang-Ting Rd., Jiangsu, Yangzhou, China
(författare)
Organo-ptii complexes for potent photodynamic inactivation of multi-drug resistant bacteria and the influence of configuration
- Artikel/kapitelEngelska2024
Förlag, utgivningsår, omfång ...
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John Wiley & Sons,2024
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:umu-220873
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-220873URI
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https://doi.org/10.1002/advs.202306936DOI
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Språk:engelska
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Sammanfattning på:engelska
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Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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PtII based organometallic photosensitizers (PSs) have emerged as novel potent photodynamic inactivation (PDI) reagents through their enhanced intersystem crossing (ISC) processes. Currently, few PtII PSs have been investigated as antibacterial materials, with relatively poor performances reported and with structure-activity relationships not well described. Herein, a pair of configurational isomers are reported of Bis-BODIPY (4,4-difluoro-boradizaindacene) embedded PtII PSs. The cis-isomer (cis-BBP) displayed enhanced 1O2 generation and better bacterial membrane anchoring capability as compared to the trans-isomer (trans-BBP). The effective PDI concentrations (efficiency > 99.9%) for cis-BBP in Acinetobacter baumannii (multi-drug resistant (MDR)) and Staphylococcus aureus are 400 nM (12 J cm−2) and 100 nM (18 J cm−2), respectively; corresponding concentrations and light doses for trans-BBP in the two bacteria are 2.50 µM (30 J cm−2) and 1.50 µM (18 J cm−2), respectively. The 50% and 90% minimum inhibitory concentration (MIC50 and MIC90) ratio of trans-BBP to cis-BBP is 22.22 and 24.02 in A. baumannii (MDR); 21.29 and 22.36 in methicillin resistant S. aureus (MRSA), respectively. Furthermore, cis-BBP displays superior in vivo antibacterial performance, with acceptable dark and photoinduced cytotoxicity. These results demonstrate cis-BBP is a robust light-assisted antibacterial reagent at sub-micromolecular concentrations. More importantly, configuration of PtII PSs should be an important issue to be considered in further PDI reagents design.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Liu, XuanweiDepartment of Chemical and Chemical Engineering, Yangzhou University, No. 180, Si-Wang-Ting Rd., Jiangsu, Yangzhou, China
(författare)
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Fang, SiyuDepartment of Chemical and Chemical Engineering, Yangzhou University, No. 180, Si-Wang-Ting Rd., Jiangsu, Yangzhou, China
(författare)
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Yang, XiaofeiDepartment of Chemical and Chemical Engineering, Yangzhou University, No. 180, Si-Wang-Ting Rd., Jiangsu, Yangzhou, China
(författare)
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Zhang, YuefeiDepartment of Emergency, Affiliated Hospital of Yangzhou University, Jiangsu, Yangzhou, China
(författare)
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Wang, TianyiDepartment of Chemical and Chemical Engineering, Yangzhou University, No. 180, Si-Wang-Ting Rd., Jiangsu, Yangzhou, China
(författare)
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Liu, LinSchool of Nursing, Yangzhou University, Yangzhou, China; Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and, Treatment of Senile Diseases, No. 88 South University Rd., Yangzhou, China
(författare)
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Kan, YinshiSchool of Nursing, Yangzhou University, Yangzhou, China; Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and, Treatment of Senile Diseases, No. 88 South University Rd., Yangzhou, China
(författare)
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Zhao, YueqiSchool of Nursing, Yangzhou University, Yangzhou, China; Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and, Treatment of Senile Diseases, No. 88 South University Rd., Yangzhou, China
(författare)
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Fan, HongyingTesting Center of Yangzhou University, No. 48 Wenhui East Rd., Yangzhou, China
(författare)
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Zhang, JingqiSchool of Materials Science and Engineering, University of Science and Technology Beijing, Beijing, China
(författare)
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Wang, XiaoyuSchool of Materials Science and Engineering, University of Science and Technology Beijing, Beijing, China
(författare)
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Yao, HangDepartment of Chemical and Chemical Engineering, Yangzhou University, No. 180, Si-Wang-Ting Rd., Jiangsu, Yangzhou, China
(författare)
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Yang, YiCenter Laboratory, Affiliated Hospital of Yangzhou University, Yangzhou, China
(författare)
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Gao, YijianCollege of Pharmaceutical Sciences, Soochow University, Suzhou, China
(författare)
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Zhao, QiCollege of Pharmaceutical Sciences, Soochow University, Suzhou, China
(författare)
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Li, ShengliangCollege of Pharmaceutical Sciences, Soochow University, Suzhou, China
(författare)
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Plymoth, MartinUmeå universitet,Institutionen för klinisk mikrobiologi,Westmead hospital, NSW, Sydney, Australia(Swepub:umu)mapl0020
(författare)
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Xi, JuqunDepartment of Pharmacology, Institute of Translational Medicine, School of Medicine, Yangzhou University, Yangzhou, China; Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and, Treatment of Senile Diseases, Yangzhou, China
(författare)
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Zhang, YuSchool of Nursing, Yangzhou University, Yangzhou, China; Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and, Treatment of Senile Diseases, No. 88 South University Rd., Yangzhou, China
(författare)
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Wang, ChengyinDepartment of Chemical and Chemical Engineering, Yangzhou University, No. 180, Si-Wang-Ting Rd., Jiangsu, Yangzhou, China
(författare)
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Pang, HuanDepartment of Chemical and Chemical Engineering, Yangzhou University, No. 180, Si-Wang-Ting Rd., Jiangsu, Yangzhou, China
(författare)
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Department of Chemical and Chemical Engineering, Yangzhou University, No. 180, Si-Wang-Ting Rd., Jiangsu, Yangzhou, ChinaDepartment of Emergency, Affiliated Hospital of Yangzhou University, Jiangsu, Yangzhou, China
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Advanced Science: John Wiley & Sons11:142198-3844
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Till lärosätets databas
- Av författaren/redakt...
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Chong, Hui
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Liu, Xuanwei
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Fang, Siyu
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Yang, Xiaofei
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Zhang, Yuefei
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Wang, Tianyi
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visa fler...
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Liu, Lin
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Kan, Yinshi
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Zhao, Yueqi
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Fan, Hongying
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Zhang, Jingqi
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Wang, Xiaoyu
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Yao, Hang
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Yang, Yi
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Gao, Yijian
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Zhao, Qi
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Li, Shengliang
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Plymoth, Martin
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Xi, Juqun
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Zhang, Yu
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Wang, Chengyin
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Pang, Huan
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Infektionsmedici ...
- Artiklar i publikationen
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Advanced Science
- Av lärosätet
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Umeå universitet