Sökning: onr:"swepub:oai:DiVA.org:umu-221529" >
Antibacterial mouth...
Antibacterial mouthwash alters gut microbiome, reducing nutrient absorption and fat accumulation in Western diet-fed mice
-
- Carvalho, Lucas Rannier Ribeiro Antonino (författare)
- Department of Physiology and Pharmacology, Karolinska Institutet, Biomedicum, 5B, Solna, Stockholm, Sweden
-
- Boeder, Ariela M. (författare)
- Department of Physiology and Pharmacology, Karolinska Institutet, Biomedicum, 5B, Solna, Stockholm, Sweden; Department of Pharmacology, Federal University of Santa Catarina, Florianópolis, Brazil
-
- Shimari, Miho (författare)
- Department of Physiology and Pharmacology, Karolinska Institutet, Biomedicum, 5B, Solna, Stockholm, Sweden
-
visa fler...
-
- Kleschyov, Andrei L. (författare)
- Department of Physiology and Pharmacology, Karolinska Institutet, Biomedicum, 5B, Solna, Stockholm, Sweden
-
- Esberg, Anders (författare)
- Umeå universitet,Institutionen för odontologi
-
- Johansson, Ingegerd (författare)
- Umeå universitet,Institutionen för odontologi
-
- Weitzberg, Eddie (författare)
- Department of Physiology and Pharmacology, Karolinska Institutet, Biomedicum, 5B, Solna, Stockholm, Sweden; Department of Perioperative Medicine and Intensive Care, Karolinska Hospital, Stockholm, Sweden
-
- Lundberg, Jon O. (författare)
- Department of Physiology and Pharmacology, Karolinska Institutet, Biomedicum, 5B, Solna, Stockholm, Sweden
-
- Carlstrom, Mattias (författare)
- Department of Physiology and Pharmacology, Karolinska Institutet, Biomedicum, 5B, Solna, Stockholm, Sweden
-
visa färre...
-
(creator_code:org_t)
- Nature Publishing Group, 2024
- 2024
- Engelska.
-
Ingår i: Scientific Reports. - : Nature Publishing Group. - 2045-2322. ; 14:1
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://umu.diva-por... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- Prolonged use of antibacterial mouthwash is linked to an increased risk of systemic disease. We aimed to investigate if disturbing the oral microbiota would impact the lower gut microbiome with functional effects in diet-induced obesity. Mice were exposed to oral chlorhexidine and fed a Western diet (WD). Food intake and weight gain were monitored, and metabolic function, blood pressure, and microbiota were analyzed. Chlorhexidine reduced the number of viable bacteria in the mouth and lowered species richness in the gut but with proportional enrichment of some bacteria linked to metabolic pathways. In mice fed a Western diet, chlorhexidine reduced weight gain, body fat, steatosis, and plasma insulin without changing caloric intake, while increasing colon triglycerides and proteins, suggesting reduced absorption of these nutrients. The mechanisms behind these effects as well as the link between the oral microbiome and small intestinal function need to be pinpointed. While the short-term effects of chlorhexidine in this model appear beneficial, potential long-term disruptions in the oral and gut microbiota and possible malabsorption should be considered.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas