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  • Timmins, Iain R.Division of Genetics and Epidemiology, Institute of Cancer Research, London, United Kingdom; Statistical Innovation, AstraZeneca, Cambridge, United Kingdom (författare)

International pooled analysis of leisure-time physical activity and premenopausal breast cancer in women from 19 cohorts

  • Artikel/kapitelEngelska2024

Förlag, utgivningsår, omfång ...

  • American Society of Clinical Oncology,2024
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:umu-222419
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-222419URI
  • https://doi.org/10.1200/JCO.23.01101DOI

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  • Språk:engelska
  • Sammanfattning på:engelska

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  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • PURPOSE: There is strong evidence that leisure-time physical activity is protective against postmenopausal breast cancer risk but the association with premenopausal breast cancer is less clear. The purpose of this study was to examine the association of physical activity with the risk of developing premenopausal breast cancer.METHODS: We pooled individual-level data on self-reported leisure-time physical activity across 19 cohort studies comprising 547,601 premenopausal women, with 10,231 incident cases of breast cancer. Multivariable Cox regression was used to estimate hazard ratios (HRs) and 95% CIs for associations of leisure-time physical activity with breast cancer incidence. HRs for high versus low levels of activity were based on a comparison of risk at the 90th versus 10th percentiles of activity. We assessed the linearity of the relationship and examined subtype-specific associations and effect modification across strata of breast cancer risk factors, including adiposity.RESULTS: Over a median 11.5 years of follow-up (IQR, 8.0-16.1 years), high versus low levels of leisure-time physical activity were associated with a 6% (HR, 0.94 [95% CI, 0.89 to 0.99]) and a 10% (HR, 0.90 [95% CI, 0.85 to 0.95]) reduction in breast cancer risk, before and after adjustment for BMI, respectively. Tests of nonlinearity suggested an approximately linear relationship (Pnonlinearity = .94). The inverse association was particularly strong for human epidermal growth factor receptor 2-enriched breast cancer (HR, 0.57 [95% CI, 0.39 to 0.84]; Phet = .07). Associations did not vary significantly across strata of breast cancer risk factors, including subgroups of adiposity.CONCLUSION: This large, pooled analysis of cohort studies adds to evidence that engagement in higher levels of leisure-time physical activity may lead to reduced premenopausal breast cancer risk.

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Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Jones, Michael E.Division of Genetics and Epidemiology, Institute of Cancer Research, London, United Kingdom (författare)
  • O'Brien, Katie M.Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, United States (författare)
  • Adami, Hans-OlovClinical Effectiveness Group, Institute of Health and Society, University of Oslo, Oslo, Norway; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (författare)
  • Aune, DagfinnDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; Department of Nutrition, Oslo New University College, Oslo, Norway; Department of Research, Cancer Registry of Norway, Oslo, Norway (författare)
  • Baglietto, LauraDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy (författare)
  • Bertrand, Kimberly A.Slone Epidemiology Center at Boston University, MA, Boston, United States (författare)
  • Brantley, Kristen D.Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States (författare)
  • Chen, YuDivision of Epidemiology, Department of Population Health, NYU Grossman School of Medicine, New York, NY (författare)
  • Clague DeHart, JessicaSchool of Community and Global Health, Claremont Graduate University, CA, Claremont, United States (författare)
  • Clendenen, Tess V.Division of Epidemiology, Department of Population Health, NYU Grossman School of Medicine, New York, NY (författare)
  • Dossus, LaureNutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France (författare)
  • Eliassen, A HeatherDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, MA, Boston, United States (författare)
  • Fletcher, OliviaBreast Cancer Now Toby Robins Research Centre, Institute of Cancer Research, London, United Kingdom (författare)
  • Fournier, AgnèsUVSQ, CESP, Gustave Roussy, Heredity, Cancer, INSERM, Paris-Saclay University, Paris-South University, Villejuif, France (författare)
  • Håkansson, NiclasUnit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (författare)
  • Hankinson, Susan E.Department of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts, MA, Amherst, United States (författare)
  • Houlston, Richard S.Division of Genetics and Epidemiology, Institute of Cancer Research, London, United Kingdom (författare)
  • Joshu, Corinne E.Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, MD, Baltimore, Liberia (författare)
  • Kirsh, Victoria A.Ontario Institute for Cancer Research, ON, Toronto, Canada; Dalla Lana School of Public Health, University of Toronto, ON, Toronto, Canada (författare)
  • Kitahara, Cari M.Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Bethesda, Liberia (författare)
  • Koh, Woon-PuayHealthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Singapore Institute for Clinical Sciences, Agency for Science Technology and Research (A*STAR), Singapore (författare)
  • Linet, Martha S.Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, Bethesda, Liberia (författare)
  • Park, Hannah LuiDepartment of Pathology and Laboratory Medicine, Department of Epidemiology, UC Irvine School of Medicine, CA, Irvine, United States (författare)
  • Lynch, Brigid M.Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia; Physical Activity Laboratory, Baker Heart and Diabetes Institute, Melbourne, VIC, Australia (författare)
  • May, Anne M.Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands (författare)
  • Mellemkjær, LeneDanish Cancer Society Research Center, Copenhagen, Denmark (författare)
  • Milne, Roger L.Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia (författare)
  • Palmer, Julie R.Slone Epidemiology Center at Boston University, MA, Boston, United States (författare)
  • Ricceri, FulvioDepartment of Clinical and Biological Sciences, Centre for Biostatistics, Epidemiology, Public Health, University of Turin, Turin, Italy; Unit of Epidemiology, Regional Health Service ASL TO3, Turin, Italy (författare)
  • Rohan, Thomas E.Albert Einstein College of Medicine, NY, Bronx, United States (författare)
  • Ruddy, Kathryn J.Department of Oncology, Mayo Clinic, MN, Rochester, United States (författare)
  • Sánchez, Maria-JoseEscuela Andaluza de Salud Pública (EASP), Granada, Spain; Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain (författare)
  • Shu, Xiao-OuDivision of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, TN, Nashville, United States (författare)
  • Smith-Byrne, KarlCancer Epidemiology Unit, University of Oxford, Oxford, United Kingdom (författare)
  • Steindorf, KarenDivision of Physical Activity, Prevention and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany (författare)
  • Sund, MalinUmeå universitet,Kirurgi,Department of Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland(Swepub:umu)masu0021 (författare)
  • Vachon, Celine M.Department of Quantitative Health Sciences, Division of Epidemiology, Mayo Clinic, MN, Rochester, United States (författare)
  • Vatten, Lars J.Department of Public Health and Nursing, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway (författare)
  • Visvanathan, KalaDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, MD, Baltimore, Liberia (författare)
  • Weiderpass, ElisabeteInternational Agency for Research on Cancer, World Health Organization, Lyon, France (författare)
  • Willett, Walter C.Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, MA, Boston, United States (författare)
  • Wolk, AlicjaUnit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (författare)
  • Yuan, Jian-MinDivision of Cancer Control and Population Sciences, University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center, PA, Pittsburgh, United States; Department of Epidemiology, School of Public Health, University of Pittsburgh, PA, Pittsburgh, United States (författare)
  • Zheng, WeiDivision of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, TN, Nashville, United States (författare)
  • Nichols, Hazel B.Department of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC, United States (författare)
  • Sandler, Dale P.Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, United States (författare)
  • Swerdlow, Anthony J.Division of Genetics and Epidemiology, Institute of Cancer Research, London, United Kingdom; Division of Breast Cancer Research, Institute of Cancer Research, London, United Kingdom (författare)
  • Schoemaker, Minouk J.Division of Genetics and Epidemiology, Institute of Cancer Research, London, United Kingdom; Real World Solutions, Amsterdam, Netherlands (författare)
  • Division of Genetics and Epidemiology, Institute of Cancer Research, London, United Kingdom; Statistical Innovation, AstraZeneca, Cambridge, United KingdomDivision of Genetics and Epidemiology, Institute of Cancer Research, London, United Kingdom (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Journal of Clinical Oncology: American Society of Clinical Oncology42:8, s. 927-9390732-183X1527-7755

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