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Freezing of gait in...
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Kihlstedt, Carl-JohanUmeå universitet,Institutionen för klinisk vetenskap
(författare)
Freezing of gait in idiopathic normal pressure hydrocephalus
- Artikel/kapitelEngelska2024
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BioMed Central (BMC),2024
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LIBRIS-ID:oai:DiVA.org:umu-222428
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-222428URI
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https://doi.org/10.1186/s12987-024-00522-yDOI
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Språk:engelska
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Sammanfattning på:engelska
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Background: Reports of freezing of gait (FoG) in idiopathic normal pressure hydrocephalus (iNPH) are few and results are variable. This study's objective was to evaluate the frequency of FoG in a large cohort of iNPH patients, identify FoG-associated factors, and assess FoG’s responsiveness to shunt surgery.Methods: Videotaped standardized gait protocols with iNPH patients pre- and post-shunt surgery (n = 139; median age 75 (71–79) years; 48 women) were evaluated for FoG episodes by two observers (Cohens kappa = 0.9, p < 0.001). FoG episodes were categorized. Mini-mental state examination (MMSE) and MRI white matter hyperintensities (WMH) assessment using the Fazekas scale were performed. CSF was analyzed for Beta-amyloid, Tau, and Phospho-tau. Patients with and without FoG were compared.Results: Twenty-two patients (16%) displayed FoG at baseline, decreasing to seven (8%) after CSF shunt surgery (p = 0.039). The symptom was most frequently exhibited during turning (n = 16, 73%). Patients displaying FoG were older (77.5 vs. 74.6 years; p = 0.029), had a slower walking speed (0.59 vs. 0.89 m/s; p < 0.001), a lower Tinetti POMA score (6.8 vs. 10.8; p < 0.001), lower MMSE score (21.3 vs. 24.0; p = 0.031), and longer disease duration (4.2 vs. 2.3 years; p < 0.001) compared to patients not displaying FoG. WMH or CSF biomarkers did not differ between the groups.Conclusions: FoG is occurring frequently in iNPH patients and may be considered a typical feature of iNPH. FoG in iNPH was associated with higher age, longer disease duration, worse cognitive function, and a more unstable gait. Shunt surgery seems to improve the symptom.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Malm, Jan,Professor,1957-Umeå universitet,Neurovetenskaper(Swepub:umu)jama0002
(författare)
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Fasano, AlfonsoEdmond J. Safra Program in Parkinson’s Disease, Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, UHN, ON, Toronto, Canada; Division of Neurology, University of Toronto, ON, Toronto, Canada; Krembil Brain Institute, ON, Toronto, Canada; Center for Advancing Neurotechnological Innovation to Application (CRANIA), ON, Toronto, Canada
(författare)
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Bäckström, David C,M.D.1978-Umeå universitet,Neurovetenskaper(Swepub:umu)dadbam02
(författare)
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Umeå universitetInstitutionen för klinisk vetenskap
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Fluids and Barriers of the CNS: BioMed Central (BMC)21:12045-8118
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