Sökning: onr:"swepub:oai:DiVA.org:umu-222894" > Research protocol f...
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000 | 10137naa a2201057 4500 | |
001 | oai:DiVA.org:umu-222894 | |
003 | SwePub | |
008 | 240405s2024 | |||||||||||000 ||eng| | |
009 | oai:lup.lub.lu.se:d845304e-bb48-4d78-aad2-80bed43b702c | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-2228942 URI |
024 | 7 | a https://doi.org/10.1016/j.euros.2024.02.0192 DOI |
024 | 7 | a https://lup.lub.lu.se/record/d845304e-bb48-4d78-aad2-80bed43b702c2 URI |
040 | a (SwePub)umud (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Rajwa, Pawelu Department of Urology, Medical University of Silesia, Zabrze, Poland; Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria4 aut |
245 | 1 0 | a Research protocol for an observational health data analysis on the adverse events of systemic treatment in patients with metastatic hormone-sensitive prostate cancer :b big data analytics using the PIONEER platform |
264 | 1 | b Elsevier,c 2024 |
338 | a electronic2 rdacarrier | |
520 | a Combination therapies in metastatic hormone-sensitive prostate cancer (mHSPC), which include the addition of an androgen receptor signaling inhibitor and/or docetaxel to androgen deprivation therapy, have been a game changer in the management of this disease stage. However, these therapies come with their fair share of toxicities and side effects. The goal of this observational study is to report drug-related adverse events (AEs), which are correlated with systemic combination therapies for mHSPC. Determining the optimal treatment option requires large cohorts to estimate the tolerability and AEs of these combination therapies in “real-life” patients with mHSPC, as provided in this study. We use a network of databases that includes population-based registries, electronic health records, and insurance claims, containing the overall target population and subgroups of patients defined by unique certain characteristics, demographics, and comorbidities, to compute the incidence of common AEs associated with systemic therapies in the setting of mHSPC. These data sources are standardised using the Observational Medical Outcomes Partnership Common Data Model. We perform the descriptive statistics as well as calculate the AE incidence rate separately for each treatment group, stratified by age groups and index year. The time until the first event is estimated using the Kaplan-Meier method within each age group. In the case of episodic events, the anticipated mean cumulative counts of events are calculated. Our study will allow clinicians to tailor optimal therapies for mHSPC patients, and they will serve as a basis for comparative method studies. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Urologi och njurmedicin0 (SwePub)302142 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Urology and Nephrology0 (SwePub)302142 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
653 | a Androgen receptor signaling inhibitor | |
653 | a Big data | |
653 | a Docetaxel | |
653 | a Hormone sensitive | |
653 | a Metastatic | |
653 | a PIONEER | |
653 | a Prostate cancer | |
653 | a Androgen receptor signaling inhibitor | |
653 | a Big data | |
653 | a Docetaxel | |
653 | a Hormone sensitive | |
653 | a Metastatic | |
653 | a PIONEER | |
653 | a Prostate cancer | |
700 | 1 | a Borkowetz, Angelikau Department of Urology, University Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany,University Clinic Carl Gustav Carus at the TU Dresden4 aut |
700 | 1 | a Abbott, Thomasu European Association of Urology, Nijmegen, Netherlands4 aut |
700 | 1 | a Alberti, Andreau Unit of Urological Robotic Surgery and Renal Transplantation, University of Florence, Careggi Hospital, Florence, Italy4 aut |
700 | 1 | a Bjartell, Andersu Lund University,Lunds universitet,Avdelningen för translationell cancerforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Urologisk cancerforskning, Malmö,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Division of Translational Cancer Research,Department of Laboratory Medicine,Faculty of Medicine,Urological cancer, Malmö,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments4 aut0 (Swepub:lu)kir-abj |
700 | 1 | a Brash, James T.u IQVIA, Real World Solutions, Brighton, United Kingdom,IQVIA Inc.4 aut |
700 | 1 | a Campi, Riccardou Unit of Urological Robotic Surgery and Renal Transplantation, University of Florence, Careggi Hospital, Florence, Italy4 aut |
700 | 1 | a Chilelli, Andrewu Astellas Pharma Europe Ltd, Surrey, United Kingdom4 aut |
700 | 1 | a Conover, Mitchellu Janssen Research & Development, NJ, Titusville, United States,Janssen Research & Development, Belgium4 aut |
700 | 1 | a Constantinovici, Niculaeu Bayer AG, Berlin, Germany,Bayer Pharma AG4 aut |
700 | 1 | a Davies, Eleanoru IQVIA, Real World Solutions, Brighton, United Kingdom,IQVIA Inc.4 aut |
700 | 1 | a De Meulder, Bertrandu Association EISBM, Vourles, France4 aut |
700 | 1 | a Eid, Sherrineu SAS Institute, NC, Cary, United States4 aut |
700 | 1 | a Gacci, Maurou Unit of Urological Robotic Surgery and Renal Transplantation, University of Florence, Careggi Hospital, Florence, Italy4 aut |
700 | 1 | a Golozar, Asiehu Odysseus Data Services, NY, New York, United States; OHDSI Center, Northeastern University, MA, Boston, United States4 aut |
700 | 1 | a Hafeez, Haroonu Shaukat Khanum Memorial Cancer Hospital & Research Centre, Peshawar, Pakistan4 aut |
700 | 1 | a Haque, Samiulu SAS Institute, NC, Cary, United States4 aut |
700 | 1 | a Hijazy, Aymanu Association EISBM, Vourles, France4 aut |
700 | 1 | a Hulsen, Timu Department of Hospital Services & Informatics, Philips Research, Eindhoven, Netherlands4 aut |
700 | 1 | a Josefsson, Andreas,d 1979-u Umeå University,Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Institutionen för diagnostik och intervention,Department of Urology, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden4 aut0 (Swepub:umu)aasjon01 |
700 | 1 | a Khalid, Sarau University of Oxford, Oxford, United Kingdom4 aut |
700 | 1 | a Kolde, Raivou Institute of Computer Science, University of Tartu, Estonia, Tartu, Estonia4 aut |
700 | 1 | a Kotik, Danielu Center for Advanced Systems Understanding, Görlitz, Germany; Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany4 aut |
700 | 1 | a Kurki, Samuu Bayer OY, Turku, Finland4 aut |
700 | 1 | a Lambrecht, Marku SAS Institute, NC, Cary, United States4 aut |
700 | 1 | a Leung, Chi-Hou S.H. Ho Urology Centre, Department of Surgery, The Chinese University of Hong Kong, Hong Kong, Hong Kong4 aut |
700 | 1 | a Moreno, Juliau SAS Institute, NC, Cary, United States4 aut |
700 | 1 | a Nicoletti, Rossellau Unit of Urological Robotic Surgery and Renal Transplantation, University of Florence, Careggi Hospital, Florence, Italy4 aut |
700 | 1 | a Nieboer, Daanu Erasmus MC University Medical Center, Rotterdam, Netherlands4 aut |
700 | 1 | a Oja, Mareku Institute of Computer Science, University of Tartu, Estonia, Tartu, Estonia4 aut |
700 | 1 | a Palanisamy, Soundaryau SAS Institute, NC, Cary, United States4 aut |
700 | 1 | a Prinsen, Peteru Netherlands Comprehensive Cancer Organisation (IKNL), Utrecht, Netherlands4 aut |
700 | 1 | a Reich, Christianu Odysseus Data Services, NY, New York, United States; OHDSI Center, Northeastern University, MA, Boston, United States4 aut |
700 | 1 | a Raffaele Resta, Giuliou Unit of Urological Robotic Surgery and Renal Transplantation, University of Florence, Careggi Hospital, Florence, Italy4 aut |
700 | 1 | a Ribal, Maria J.u Uro-Oncology Unit, Hospital Clinic, University of Barcelona, Barcelona, Spain4 aut |
700 | 1 | a Gómez Rivas, Juanu Department of Urology, Hospital Clinico San Carlos, Madrid, Spain4 aut |
700 | 1 | a Smith, Emmau Guidelines Office, European Association of Urology, Arnhem, Netherlands4 aut |
700 | 1 | a Snijder, Robertu Janssen Research & Development, NJ, Titusville, United States,Janssen Research & Development, Belgium4 aut |
700 | 1 | a Steinbeisser, Carlu Collaborate Project Management, Munich, Germany4 aut |
700 | 1 | a Vandenberghe, Frederiku SAS Institute, NC, Cary, United States4 aut |
700 | 1 | a Cornford, Philipu Liverpool University Hospitals NHS Trust, Liverpool, United Kingdom,University of Liverpool4 aut |
700 | 1 | a Evans-Axelsson, Susanu Bayer AG, Berlin, Germany,Bayer Pharma AG4 aut0 (Swepub:lu)med-ses |
700 | 1 | a N'Dow, Jamesu Academic Urology Unit, University of Aberdeen, Aberdeen, United Kingdom4 aut |
700 | 1 | a Willemse, Peter-Paul M.u Department of Urology, Cancer Center, University Medical Center Utrecht, Utrecht, Netherlands4 aut |
710 | 2 | a Department of Urology, Medical University of Silesia, Zabrze, Poland; Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austriab Department of Urology, University Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany4 org |
773 | 0 | t European Urology Open Scienced : Elsevierg 63, s. 81-88q 63<81-88x 2666-1691x 2666-1683 |
856 | 4 | u https://doi.org/10.1016/j.euros.2024.02.019y Fulltext |
856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:1848929/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u http://dx.doi.org/10.1016/j.euros.2024.02.019x freey FULLTEXT |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-222894 |
856 | 4 8 | u https://doi.org/10.1016/j.euros.2024.02.019 |
856 | 4 8 | u https://lup.lub.lu.se/record/d845304e-bb48-4d78-aad2-80bed43b702c |
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