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Sökning: onr:"swepub:oai:DiVA.org:umu-223230" > Long-term exposure ...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00007574naa a2200505 4500
001oai:DiVA.org:umu-223230
003SwePub
008240419s2024 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-2232302 URI
0247 a https://doi.org/10.1016/j.jhazmat.2024.1341612 DOI
040 a (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Wu, Qi-Zhenu Joint International Research Laboratory of Environment and Health, Ministry of Education, Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou, China4 aut
2451 0a Long-term exposure to major constituents of fine particulate matter and neurodegenerative diseases :b a population-based survey in the Pearl River Delta Region, China
264 1b Elsevier,c 2024
338 a print2 rdacarrier
520 a Background: Exposure to PM2.5 has been linked to neurodegenerative diseases, with limited understanding of constituent-specific contributions.Objectives: To explore the associations between long-term exposure to PM2.5 constituents and neurodegenerative diseases.Methods: We recruited 148,274 individuals aged ≥ 60 from four cities in the Pearl River Delta region, China (2020 to 2021). We calculated twenty-year average air pollutant concentrations (PM2.5 mass, black carbon (BC), organic matter (OM), ammonium (NH4+), nitrate (NO3-) and sulfate (SO42-)) at the individuals' home addresses. Neurodegenerative diseases were determined by self-reported doctor-diagnosed Alzheimer's disease (AD) and Parkinson's disease (PD). Generalized linear mixed models were employed to explore associations between pollutants and neurodegenerative disease prevalence.Results: PM2.5 and all five constituents were significantly associated with a higher prevalence of AD and PD. The observed associations generally exhibited a non-linear pattern. For example, compared with the lowest quartile, higher quartiles of BC were associated with greater odds for AD prevalence (i.e., the adjusted odds ratios were 1.81; 95% CI, 1.45–2.27; 1.78; 95% CI, 1.37–2.32; and 1.99; 95% CI, 1.54–2.57 for the second, third, and fourth quartiles, respectively).Conclusions: Long-term exposure to PM2.5 and its constituents, particularly combustion-related BC, OM, and SO42-, was significantly associated with higher prevalence of AD and PD in Chinese individuals.Environmental implication: PM2.5 is a routinely regulated mixture of multiple hazardous constituents that can lead to diverse adverse health outcomes. However, current evidence on the specific contributions of PM2.5 constituents to health effects is scarce. This study firstly investigated the association between PM2.5 constituents and neurodegenerative diseases in the moderately to highly polluted Pearl River Delta region in China, and identified hazardous constituents within PM2.5 that have significant impacts. This study provides important implications for the development of targeted PM2.5 prevention and control policies to reduce specific hazardous PM2.5 constituents.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Arbetsmedicin och miljömedicin0 (SwePub)303032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Occupational Health and Environmental Health0 (SwePub)303032 hsv//eng
653 a Alzheimer's disease
653 a China
653 a Health risk
653 a Parkinson's disease
653 a PM2.5 constituent
7001 a Zeng, Hui-Xianu Joint International Research Laboratory of Environment and Health, Ministry of Education, Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou, China4 aut
7001 a Andersson, Johnu Umeå universitet,Institutionen för psykologi4 aut0 (Swepub:umu)jonann98
7001 a Oudin, Annau Umeå universitet,Institutionen för folkhälsa och klinisk medicin4 aut0 (Swepub:umu)anou0004
7001 a Kanninen, Katja M.u A.I.Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland4 aut
7001 a Xu, Mu-Wuu Department of Epidemiology and Environment Health, School of Public and Health Professions, University at Buffalo, Buffalo, United States4 aut
7001 a Qin, Shuang-Jianu Joint International Research Laboratory of Environment and Health, Ministry of Education, Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou, China4 aut
7001 a Zeng, Qing-Guou Joint International Research Laboratory of Environment and Health, Ministry of Education, Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou, China4 aut
7001 a Zhao, Binu State Key Joint Laboratory of Environmental Simulation and Pollution Control, School of Environment, Tsinghua University, Beijing, China; State Environmental Protection Key Laboratory of Sources and Control of Air Pollution Complex, Beijing, China4 aut
7001 a Zheng, Meiu SKL-ESPC, College of Environmental Sciences and Engineering, Center for Environment and Health, Peking University, Beijing, China4 aut
7001 a Jin, Nanxiangu A.I.Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland4 aut
7001 a Chou, Wei-Chunu Center for Environmental and Human Toxicology, Department of Environmental and Global Health, College of Public Health and Health Professions, University of Florida, FL, Gainesville, United States4 aut
7001 a Jalava, Pasiu Department of Environmental and Biological Science, University of Eastern Finland, Kuopio, Finland4 aut
7001 a Dong, Guang-Huiu Joint International Research Laboratory of Environment and Health, Ministry of Education, Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou, China4 aut
7001 a Zeng, Xiao-Wenu Joint International Research Laboratory of Environment and Health, Ministry of Education, Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou, China4 aut
7102 a Joint International Research Laboratory of Environment and Health, Ministry of Education, Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou, Chinab Institutionen för psykologi4 org
7730 t Journal of Hazardous Materialsd : Elsevierg 470q 470x 0304-3894x 1873-3336
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-223230
8564 8u https://doi.org/10.1016/j.jhazmat.2024.134161

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