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A polygenic score p...
A polygenic score predicts caries experience in elderly Swedish adults
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- Fries, Niklas, 1991- (författare)
- Umeå universitet,Institutionen för matematik och matematisk statistik,Institutionen för odontologi
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- Haworth, S. (författare)
- University of Bristol, Bristol, United Kingdom
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- Shaffer, J.R. (författare)
- University of Pittsburgh, PA, Pittsburgh, United States
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visa fler...
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- Esberg, Anders (författare)
- Umeå universitet,Institutionen för odontologi
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- Divaris, K. (författare)
- University of North Carolina at Chapel Hill, Chapel Hill, NC, United States
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- Marazita, M.L. (författare)
- University of Pittsburgh, PA, Pittsburgh, United States
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- Johansson, I. (författare)
- Umeå universitet
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(creator_code:org_t)
- Sage Publications, 2024
- 2024
- Engelska.
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Ingår i: Journal of Dental Research. - : Sage Publications. - 0022-0345 .- 1544-0591. ; 103:5, s. 502-508
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Caries is a partially heritable disease, raising the possibility that a polygenic score (PS, a summary of an individual’s genetic propensity for disease) might be a useful tool for risk assessment. To date, PS for some diseases have shown clinical utility, although no PS for caries has been evaluated. The objective of the study was to test whether a PS for caries is associated with disease experience or increment in a cohort of Swedish adults. A genome-wide PS for caries was trained using the results of a published genome-wide association meta-analysis and constructed in an independent cohort of 15,460 Swedish adults. Electronic dental records from the Swedish Quality Registry for Caries and Periodontitis (SKaPa) were used to compute the decayed, missing, and filled tooth surfaces (DMFS) index and the number of remaining teeth. The performance of the PS was evaluated by testing the association between the PS and DMFS at a single dental examination, as well as between the PS and the rate of change in DMFS. Participants in the highest and lowest deciles of PS had a mean DMFS of 63.5 and 46.3, respectively. A regression analysis confirmed this association where a 1 standard deviation increase in PS was associated with approximately 4-unit higher DMFS (P < 2 × 10−16). Participants with the highest decile of PS also had greater change in DMFS during follow-up. Results were robust to sensitivity analysis, which adjusted for age, age squared, sex, and the first 20 genetic principal components. Mediation analysis suggested that tooth loss was a strong mediating factor in the association between PS and DMFS but also supported a direct genetic effect on caries. In this cohort, there are clinically meaningful differences in DMFS between participants with high and low PS for caries. The results highlight the potential role of genomic data in improving caries risk assessment.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Nyckelord
- epidemiology
- genetic risk score
- human genetics
- risk factors
- tooth demineralization
- tooth diseases
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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