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Circulating biomark...
Circulating biomarkers in pulmonary arterial hypertension : an update
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- Correale, Michele (författare)
- Cardiothoracic Department, Ospedali Riuniti University Hospital, Foggia, Italy
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- Tricarico, Lucia (författare)
- Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy
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- Bevere, Ester Maria Lucia (författare)
- Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy
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- Chirivì, Francesco (författare)
- Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy
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- Croella, Francesca (författare)
- Cardiothoracic Vascular Department, Division of Provincial Cardiology, Santissima Annunziata Hospital and Delta Hospital, Azienda Unità Sanitaria Locale di Ferrara, Ferrara, Italy
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- Severino, Paolo (författare)
- Department of Clinical, Internal, Anesthesiology and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico, Rome, Italy
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- Mercurio, Valentina (författare)
- Department of Translational Medical Sciences, Federico II University, Naples, Italy
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- Magrì, Damiano (författare)
- Department of Clinical and Molecular Medicine, Azienda Ospedaliera Sant’Andrea, “Sapienza” Università degli Studi di Roma, Rome, Italy
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- Dini, Frank L. (författare)
- Umeå universitet,Institutionen för folkhälsa och klinisk medicin,Istituto Auxologico IRCCS, Centro Medico Sant’Agostino, Via Temperanza, 6, Milan, Italy
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- Licordari, Roberto (författare)
- Department of Biomedical and Dental Sciences and Morphofunctional Imaging, Section of Cardiology, University of Messina, Messina, Italy
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- Beltrami, Matteo (författare)
- Arrhythmia and Electrophysiology Unit, Careggi University Hospital, Florence, Italy
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- Dattilo, Giuseppe (författare)
- Department of Biomedical and Dental Sciences and Morphofunctional Imaging, Section of Cardiology, University of Messina, Messina, Italy
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- Salzano, Andrea (författare)
- Cardiology Unit, AORN A Cardarelli, Naples, Italy
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- Palazzuoli, Alberto (författare)
- Cardiovascular Diseases Unit, Cardio-Thoracic and Vascular Department, S. Maria alle Scotte Hospital, University of Siena, Siena, Italy
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(creator_code:org_t)
- MDPI, 2024
- 2024
- Engelska.
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Ingår i: Biomolecules. - : MDPI. - 2218-273X. ; 14:5
- Relaterad länk:
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Pulmonary arterial hypertension (PAH) is a rare subtype of group 1 pulmonary hypertension (PH) diseases, characterized by high pulmonary artery pressure leading to right ventricular dysfunction and potential life-threatening consequences. PAH involves complex mechanisms: vasoconstriction, vascular remodeling, endothelial dysfunction, inflammation, oxidative stress, fibrosis, RV remodeling, cellular hypoxia, metabolic imbalance, and thrombosis. These mechanisms are mediated by several pathways, involving molecules like nitric oxide and prostacyclin. PAH diagnosis requires clinical evaluation and right heart catheterization, confirming a value of mPAP ≥ 20 mmHg at rest and often elevated pulmonary vascular resistance (PVR). Even if an early and accurate diagnosis is crucial, PAH still lacks effective biomarkers to assist in its diagnosis and prognosis. Biomarkers could contribute to arousing clinical suspicion and serve for prognosis prediction, risk stratification, and dynamic monitoring in patients with PAH. The aim of the present review is to report the main novelties on new possible biomarkers for the diagnosis, prognosis, and treatment monitoring of PAH.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- biomarker
- diagnosis
- pulmonary arterial hypertension
- pulmonary hypertension
- treatment
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Correale, Michel ...
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Tricarico, Lucia
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Bevere, Ester Ma ...
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Chirivì, Frances ...
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Croella, Frances ...
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Severino, Paolo
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visa fler...
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Mercurio, Valent ...
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Magrì, Damiano
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Dini, Frank L.
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Licordari, Rober ...
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Beltrami, Matteo
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Dattilo, Giusepp ...
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Salzano, Andrea
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Palazzuoli, Albe ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
- Artiklar i publikationen
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Biomolecules
- Av lärosätet
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Umeå universitet