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Changes in markers ...
Changes in markers of cobalamin status after cessation of oral B-vitamin supplements in elderly people with mild cobalamin deficiency
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Eussen, S J P M (författare)
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Ueland, P M (författare)
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Hiddink, G J (författare)
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- Schneede, Jörn (författare)
- Umeå universitet,Klinisk kemi
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Blom, H J (författare)
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Hoefnagels, W H L (författare)
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van Staveren, W A (författare)
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de Groot, L C P G M (författare)
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(creator_code:org_t)
- 2007-07-04
- 2008
- Engelska.
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Ingår i: European Journal of Clinical Nutrition. - London : John Libbey. - 0954-3007 .- 1476-5640. ; 62:10, s. 1248-1251
- Relaterad länk:
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Mildly cobalamin-deficient elderly were supplemented with 1000 microg cobalamin (group C, n=34), 1000 microg cobalamin with 400 microg folic acid (group CF, n=31) or a placebo (n=30) for 6 months. Participants provided one single blood sample 3, 5 or 7 months after cessation of supplementation to monitor early changes in plasma concentrations of cobalamin, holotranscobalamin (holoTC) and methylmalonic acid (MMA). At the end of supplementation (groups C+CF), one participant met our criteria for mild cobalamin deficiency, as did 13, 14 and 43% of the participants assessed at respectively 3, 5 and 7 months post-supplementation. Cobalamin and holoTC declined on average with 47 and 56% relative to concentrations at the end of supplementation for the group assessed at 7 months post-supplementation. Essentially similar declines were observed for those participants assessed at 3 and 5 months post-supplementation. Mean MMA concentrations increased by 15% (P=0.07) in those participants assessed at 3 and 5 months post-supplementation, and increased by 50% (P=0.002) in those participants assessed at 7 months post-supplementation. Considering MMA as a sensitive tissue marker for cobalamin status, oral supplementation may afford adequate cobalamin status for a period of up to 5 months after cessation in the majority of participants.
Nyckelord
- cobalamin deficiency
- cessation of oral supplementation
- elderly people
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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