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The importance of b...
The importance of being grade 3 : a plea for a three-tier hybrid classification system for grade in primary non–muscle-invasive bladder cancer
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- Beijert, Irene J. (författare)
- Surgical Oncology (Urology), Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, Netherlands; Urology, Amsterdam University Medical Centers, Vrije Universiteit, Amsterdam, Netherlands
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- Hagberg, Oskar (författare)
- Institution of Translational Medicine, Lund University, Malmö, Sweden
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- Gårdmark, Truls (författare)
- Department of Clinical Sciences, Danderyd Hospital, Karolinska Institute, Stockholm, Sweden
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- Holmberg, Lars (författare)
- Department of Surgical Sciences, Uppsala University, Uppsala, Sweden; School of Cancer and Pharmaceutical Sciences, King's College London, London, United Kingdom
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- Häggström, Christel (författare)
- Umeå universitet,Institutionen för diagnostik och intervention,Enheten för biobanksforskning,Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
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- Johnston, Allan (författare)
- Department of Urology, Queen Elizabeth University Hospital, Glasgow, United Kingdom
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- Trail, Matthew (författare)
- Department of Urology, Ninewells Hospital, Dundee, United Kingdom
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- Hamid, Sami (författare)
- Department of Urology, Ninewells Hospital, Dundee, United Kingdom
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- Dreyer, Barend A. (författare)
- Department of Urology, Victoria Hospital, Kirkcaldy, United Kingdom
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- Padovani, Luisa (författare)
- Edinburgh Bladder Cancer Surgery, Department of Urology, Western General Hospital, Edinburgh, United Kingdom
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- Garau, Roberta (författare)
- Edinburgh Bladder Cancer Surgery, Department of Urology, Western General Hospital, Edinburgh, United Kingdom
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- Hasan, Rami (författare)
- Edinburgh Bladder Cancer Surgery, Department of Urology, Western General Hospital, Edinburgh, United Kingdom; Department of Urology, University Hospital Ayr, Ayr, United Kingdom
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- Ahmad, Imran (författare)
- Department of Urology, Queen Elizabeth University Hospital, Glasgow, United Kingdom; School of Cancer Sciences, University of Glasgow, Glasgow, United Kingdom
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- Hendry, David (författare)
- Department of Urology, Queen Elizabeth University Hospital, Glasgow, United Kingdom
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- Compérat, Eva M. (författare)
- European Association of Urology, Non-Muscle Invasive Bladder Cancer Guidelines Panel, Arnhem, Netherlands; Pathology, Tenon Hospital, AP-HP, Sorbonne University, Paris, France
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- Burger, Maximilian (författare)
- European Association of Urology, Non-Muscle Invasive Bladder Cancer Guidelines Panel, Arnhem, Netherlands; Urology, Caritas St. Josef Medical Center, University of Regensburg, Regensburg, Germany
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- Rouprêt, Morgan (författare)
- European Association of Urology, Non-Muscle Invasive Bladder Cancer Guidelines Panel, Arnhem, Netherlands; Urology, Pitié Salpétrière Hospital, AP-HP, GRC n°5, ONCOTYPE-URO, Sorbonne University, Paris, France
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- Gontero, Paolo (författare)
- European Association of Urology, Non-Muscle Invasive Bladder Cancer Guidelines Panel, Arnhem, Netherlands; Urology, Città della Salute e della Scienza, University of Torino School of Medicine, Torino, Italy
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- Ribal, Maria J. (författare)
- European Association of Urology, Guidelines Office Board, Arnhem, Netherlands
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- van der Kwast, Theo H. (författare)
- Laboratory Medicine Program, University Health Network, Princess Margaret Cancer Center, University of Toronto, Toronto, Canada
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- Babjuk, Marko (författare)
- European Association of Urology, Non-Muscle Invasive Bladder Cancer Guidelines Panel, Arnhem, Netherlands; Urology, Teaching Hospital Motol and 2nd Faculty of Medicine, Charles University Praha, Prague, Czech Republic; Urology, Comprehensive Cancer Center, Medical University Vienna, Vienna General Hospital, Vienna, Austria
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- Sylvester, Richard J. (författare)
- European Association of Urology, Non-Muscle Invasive Bladder Cancer Guidelines Panel, Arnhem, Netherlands
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- Mariappan, Paramananthan (författare)
- Edinburgh Bladder Cancer Surgery, Department of Urology, Western General Hospital, Edinburgh, United Kingdom; European Association of Urology, Non-Muscle Invasive Bladder Cancer Guidelines Panel, Arnhem, Netherlands; University of Edinburgh, Edinburgh, United Kingdom
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- Liedberg, Fredrik (författare)
- Institution of Translational Medicine, Lund University, Malmö, Sweden; European Association of Urology, Non-Muscle Invasive Bladder Cancer Guidelines Panel, Arnhem, Netherlands; Department of Urology, Skåne University Hospital, Malmö, Sweden
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- van Rhijn, Bas W.G. (författare)
- Surgical Oncology (Urology), Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, Netherlands; European Association of Urology, Non-Muscle Invasive Bladder Cancer Guidelines Panel, Arnhem, Netherlands; Urology, Caritas St. Josef Medical Center, University of Regensburg, Regensburg, Germany; Surgical Oncology (Urology), University Health Network, Princess Margaret Cancer Center, University of Toronto, Toronto, Canada
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(creator_code:org_t)
- Elsevier, 2024
- 2024
- Engelska.
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Ingår i: European Urology. - : Elsevier. - 0302-2838 .- 1873-7560.
- Relaterad länk:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Grade is an important determinant of progression in non–muscle-invasive bladder cancer. Although the World Health Organization (WHO) 2004/2016 grading system is recommended, other systems such as WHO1973 and WHO1999 are still widely used. Recently, a hybrid (three-tier) system was proposed, separating WHO2004/2016 high grade (HG) into HG/grade 2 (G2) and HG/G3 while maintaining low grade. We assessed the prognostic performance of HG/G3 and HG/G2. Three independent cohorts with 9712 primary (first diagnosis) Ta-T1 bladder tumors were analyzed. Time to progression was analyzed with cumulative incidence functions and Cox regression models. Harrell's C-index was used to assess discrimination. Time to progression was significantly shorter for HG/G3 than for HG/G2 in multivariable analyses (cohort 1: hazard ratio [HR] = 1.92; cohort 2: HR = 2.51, and cohort 3: HR = 1.69). Corresponding progression risks at 5 yr were 18%, 20%, and 18% for HG/G3 versus 7.3%, 7.5%, and 9.3% for HG/G2, respectively. Cox models using hybrid grade performed better than models with WHO2004/2016 (all cohorts; p < 0.001). For the three cohorts, C-indices for WHO2004/2016 were 0.69, 0.62, and 0.75, while, for hybrid grade, C-indices were 0.74, 0.68, and 0.78, respectively. Subdividing the HG category into HG/G2 and HG/G3 stratifies time to progression and supports the recommendation to adopt the hybrid grading system for Ta/T1 bladder cancers.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Bladder
- Cancer
- Grading
- Hybrid grade
- World Health Organization 1973
- World Health Organization 1999
- World Health Organization 2004
- World Health Organization 2016
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Beijert, Irene J ...
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Hagberg, Oskar
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Gårdmark, Truls
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Holmberg, Lars
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Häggström, Chris ...
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Johnston, Allan
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visa fler...
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Trail, Matthew
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Hamid, Sami
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Dreyer, Barend A ...
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Padovani, Luisa
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Garau, Roberta
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Hasan, Rami
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Ahmad, Imran
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Hendry, David
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Compérat, Eva M.
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Burger, Maximili ...
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Rouprêt, Morgan
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Gontero, Paolo
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Ribal, Maria J.
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van der Kwast, T ...
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Babjuk, Marko
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Sylvester, Richa ...
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Mariappan, Param ...
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Liedberg, Fredri ...
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van Rhijn, Bas W ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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European Urology
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