Sökning: onr:"swepub:oai:DiVA.org:umu-23397" > Comparison of Franc...
Fältnamn | Indikatorer | Metadata |
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000 | 05301naa a2200901 4500 | |
001 | oai:DiVA.org:umu-23397 | |
003 | SwePub | |
008 | 090613s2007 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-233972 URI |
024 | 7 | a https://doi.org/10.1186/gb-2007-8-6-r1022 DOI |
040 | a (SwePub)umu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Rohmer, Laurence4 aut |
245 | 1 0 | a Comparison of Francisella tularensis genomes reveals evolutionary events associated with the emergence of human pathogenic strains |
264 | 1 | b BioMed Central,c 2007 |
338 | a electronic2 rdacarrier | |
520 | a BACKGROUND: Francisella tularensis subspecies tularensis and holarctica are pathogenic to humans, whereas the two other subspecies, novicida and mediasiatica, rarely cause disease. To uncover the factors that allow subspecies tularensis and holarctica to be pathogenic to humans, we compared their genome sequences with the genome sequence of Francisella tularensis subspecies novicida U112, which is nonpathogenic to humans. RESULTS: Comparison of the genomes of human pathogenic Francisella strains with the genome of U112 identifies genes specific to the human pathogenic strains and reveals pseudogenes that previously were unidentified. In addition, this analysis provides a coarse chronology of the evolutionary events that took place during the emergence of the human pathogenic strains. Genomic rearrangements at the level of insertion sequences (IS elements), point mutations, and small indels took place in the human pathogenic strains during and after differentiation from the nonpathogenic strain, resulting in gene inactivation. CONCLUSION: The chronology of events suggests a substantial role for genetic drift in the formation of pseudogenes in Francisella genomes. Mutations that occurred early in the evolution, however, might have been fixed in the population either because of evolutionary bottlenecks or because they were pathoadaptive (beneficial in the context of infection). Because the structure of Francisella genomes is similar to that of the genomes of other emerging or highly pathogenic bacteria, this evolutionary scenario may be shared by pathogens from other species. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Mikrobiologi inom det medicinska området0 (SwePub)301092 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Microbiology in the medical area0 (SwePub)301092 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Infektionsmedicin0 (SwePub)302092 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Infectious Medicine0 (SwePub)302092 hsv//eng |
653 | a Alleles | |
653 | a Bacterial Typing Techniques | |
653 | a Cluster Analysis | |
653 | a DNA Fingerprinting | |
653 | a DNA; Bacterial/analysis/chemistry/isolation & purification | |
653 | a Epidemiology; Molecular/*methods | |
653 | a Francisella tularensis/*classification/*genetics/isolation & purification | |
653 | a Genotype | |
653 | a Minisatellite Repeats | |
653 | a Molecular Sequence Data | |
653 | a Phylogeny | |
653 | a Sequence Analysis; DNA | |
653 | a Variation (Genetics)/genetics | |
700 | 1 | a Fong, Christine4 aut |
700 | 1 | a Abmayr, Simone4 aut |
700 | 1 | a Wasnick, Michael4 aut |
700 | 1 | a Larson Freeman, Theodore J4 aut |
700 | 1 | a Radey, Matthew4 aut |
700 | 1 | a Guina, Tina4 aut |
700 | 1 | a Svensson, Kerstinu Umeå universitet,Infektionssjukdomar4 aut0 (Swepub:umu)kensvn99 |
700 | 1 | a Hayden, Hillary S4 aut |
700 | 1 | a Jacobs, Michael4 aut |
700 | 1 | a Gallagher, Larry A4 aut |
700 | 1 | a Manoil, Colin4 aut |
700 | 1 | a Ernst, Robert K4 aut |
700 | 1 | a Drees, Becky4 aut |
700 | 1 | a Buckley, Danielle4 aut |
700 | 1 | a Haugen, Eric4 aut |
700 | 1 | a Bovee, Donald4 aut |
700 | 1 | a Zhou, Yang4 aut |
700 | 1 | a Chang, Jean4 aut |
700 | 1 | a Levy, Ruth4 aut |
700 | 1 | a Lim, Regina4 aut |
700 | 1 | a Gillett, Will4 aut |
700 | 1 | a Guenthener, Don4 aut |
700 | 1 | a Kang, Allison4 aut |
700 | 1 | a Shaffer, Scott A4 aut |
700 | 1 | a Taylor, Greg4 aut |
700 | 1 | a Chen, Jinzhi4 aut |
700 | 1 | a Gallis, Byron4 aut |
700 | 1 | a D'Argenio, David A4 aut |
700 | 1 | a Forsman, Matsu Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten)4 aut |
700 | 1 | a Olson, Maynard V4 aut |
700 | 1 | a Goodlett, David R4 aut |
700 | 1 | a Kaul, Rajinder4 aut |
700 | 1 | a Miller, Samuel I4 aut |
700 | 1 | a Brittnacher, Mitchell J4 aut |
710 | 2 | a Umeå universitetb Infektionssjukdomar4 org |
773 | 0 | t Genome Biologyd : BioMed Centralg 8:6q 8:6x 1465-6906x 1474-760X |
856 | 4 | u https://doi.org/10.1186/gb-2007-8-6-r102y Fulltext |
856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:223655/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u https://genomebiology.biomedcentral.com/track/pdf/10.1186/gb-2007-8-6-r102 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-23397 |
856 | 4 8 | u https://doi.org/10.1186/gb-2007-8-6-r102 |
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