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Exposure to nitroge...
Exposure to nitrogen dioxide is not associated with vascular dysfunction in man
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- Langrish, Jeremy (författare)
- Centre for Cardiovascular Sciences, University of Edinburgh, United Kingdom
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- Lundbäck, Magnus, 1976- (författare)
- Umeå universitet,Lungmedicin
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- Barath, Stefan (författare)
- Umeå universitet,Lungmedicin
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- Söderberg, Stefan (författare)
- Umeå universitet,Medicin
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- Mills, Nicholas L (författare)
- Centre for Cardiovascular Sciences, University of Edinburgh, United Kingdom
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- Newby, David (författare)
- Centre for Cardiovascular Sciences, University of Edinburgh, United Kingdom
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- Sandström, Thomas (författare)
- Umeå universitet,Lungmedicin
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- Blomberg, Anders (författare)
- Umeå universitet,Lungmedicin
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(creator_code:org_t)
- 2010-01-04
- 2010
- Engelska.
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Ingår i: Inhalation Toxicology. - : Informa Healthcare. - 0895-8378 .- 1091-7691. ; 22:3, s. 192-198
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Background: Exposure to air pollution is associated with increased cardiorespiratory morbidity and mortality. It is unclear whether these effects are mediated through combustion-derived particulate matter or gaseous components, such as nitrogen dioxide. Objectives: To investigate the effect of nitrogen dioxide exposure on vascular vasomotor and six fibrinolytic functions. Methods: Ten healthy male volunteers were exposed to nitrogen dioxide at 4 ppm or filtered air for 1 h during intermittent exercise in a randomized double-blind crossover study. Bilateral forearm blood flow and fibrinolytic markers were measured before and during unilateral intrabrachial infusion of bradykinin (100–1000 pmol/min), acetylcholine (5–20 μg/min), sodium nitroprusside (2–8 μg/min), and verapamil (10–100 μg/min) 4 h after the exposure. Lung function was determined before and after the exposure, and exhaled nitric oxide at baseline and 1 and 4 h after the exposure. Results: There were no differences in resting forearm blood flow after either exposure. There was a dose-dependent increase in forearm blood flow with all vasodilators but this was similar after either exposure for all vasodilators (p > .05 for all). Bradykinin caused a dose-dependent increase in plasma tissue-plasminogen activator, but again there was no difference between the exposures. There were no changes in lung function or exhaled nitric oxide following either exposure. Conclusion: Inhalation of nitrogen dioxide does not impair vascular vasomotor or fibrinolytic function. Nitrogen dioxide does not appear to be a major arbiter of the adverse cardiovascular effects of air pollution.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Nyckelord
- Air pollution
- endothelial function
- fibrinolysis
- nitrogen dioxide
- NO2
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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