onr:"swepub:oai:DiVA.org:umu-3086"
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03360naa a2200373 4500 | |
| 001 | oai:DiVA.org:umu-3086 | |
| 003 | SwePub | |
| 008 | 080407s2011 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-30862 URI |
| 024 | 7 | a https://doi.org/10.1371/journal.pone.00247742 DOI |
| 040 | a (SwePub)umu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Guo, Yongzhiu Umeå universitet,Institutionen för medicinsk kemi och biofysik4 aut0 (Swepub:umu)yogu0001 |
| 245 | 1 0 | a Beneficial and detrimental effects of plasmin(ogen) during infection and sepsis in mice |
| 264 | c 2011-09-12 | |
| 264 | 1 | b Public Library of Science,c 2011 |
| 338 | a electronic2 rdacarrier | |
| 500 | a Previously included in thesis in manuscript form, with title "Beneficial and detrimental effects of plasmin(ogen) during infection and sepsis". | |
| 520 | a Plasmin has been proposed to be an important mediator during inflammation/infection. In this study, by using mice lacking genes for plasminogen, tissue-type plasminogen activator (tPA), and urokinase-type PA (uPA), we have investigated the functional roles of active plasmin in infection and sepsis. Two models were used: an infection model by intravenous injection of 1x10(7) CFU of S. aureus, and a sepsis model by intravenous injection of 1.6x10(8) CFU of S. aureus. We found that in the infection model, wild-type (WT) mice showed significantly higher survival rates than plasminogen-deficient (plg(-/-)) mice. However, in the sepsis model, plg(-/-) or tPA(-/-)/uPA(-/-) mice showed the highest survival rate whereas WT and tPA(+/-)/uPA(+/-) mice showed the lowest survival rate, and plg(+/-), tPA(-/-), and uPA(-/-) mice had an intermediate survival rate. These results indicate that the levels of active plasmin are critical in determining the survival rate in the sepsis, partly through high levels of inflammatory cytokines and enhanced STAT3 activation. We conclude that plasmin is beneficial in infection but promotes the production of inflammatory cytokines in sepsis that may cause tissue destruction, diminished neutrophil function, and an impaired capacity to kill bacteria which eventually causes death of these mice. | |
| 650 | 7 | a NATURVETENSKAPx Biologi0 (SwePub)1062 hsv//swe |
| 650 | 7 | a NATURAL SCIENCESx Biological Sciences0 (SwePub)1062 hsv//eng |
| 700 | 1 | a Li, Jinanu Umeå universitet,Institutionen för medicinsk kemi och biofysik4 aut0 (Swepub:umu)jili0010 |
| 700 | 1 | a Hagström, Elinu Umeå universitet,Institutionen för medicinsk kemi och biofysik4 aut |
| 700 | 1 | a Ny, Toru Umeå universitet,Institutionen för medicinsk kemi och biofysik4 aut0 (Swepub:umu)tony0001 |
| 710 | 2 | a Umeå universitetb Institutionen för medicinsk kemi och biofysik4 org |
| 773 | 0 | t PLOS ONEd : Public Library of Scienceg 6:9q 6:9x 1932-6203 |
| 856 | 4 | u https://doi.org/10.1371/journal.pone.0024774y Fulltext |
| 856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:141540/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 | u https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0024774&type=printable |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-3086 |
| 856 | 4 8 | u https://doi.org/10.1371/journal.pone.0024774 |
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