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Chronic intermitten...
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Lundblad, MartinLund University,Lunds universitet,Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB),Basala gangliernas patofysiologi,Forskargrupper vid Lunds universitet,Basal Ganglia Pathophysiology,Lund University Research Groups
(författare)
Chronic intermittent L-DOPA treatment induces changes in dopamine release
- Artikel/kapitelEngelska2009
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Wiley,2009
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Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:umu-3140
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-3140URI
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https://doi.org/10.1111/j.1471-4159.2008.05848.xDOI
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https://lup.lub.lu.se/record/1312523URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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3,4-Dihydroxyphenyl-l-alanine (l-DOPA)-induced dyskinesia often develops as a side effect of chronic l-DOPA therapy. This study was undertaken to investigate dopamine (DA) release upon l-DOPA treatment. Chronoamperometric measurements were performed in unilaterally DA-depleted rats, chronically treated with l-DOPA, resulting in dyskinetic and non-dyskinetic animals. Normal and lesioned l-DOPA naïve animals were used as controls. Potassium-evoked DA releases were significantly reduced in intact sides of animals undertaken chronic l-DOPA treatment, independent on dyskinetic behavior. Acute l-DOPA further attenuated the amplitude of the DA release in the control sides. In DA-depleted striata, no difference was found in potassium-evoked DA releases, and acute l-DOPA did not affect the amplitude. While immunoreactivity to serotonin uptake transporter was higher in lesioned striata of animals displaying dyskinetic behavior, no correlation could be documented between serotonin transporter-positive nerve fiber density and the amplitude of released DA. In conclusions, the amplitude of potassium-evoked DA release is attenuated in intact striatum after chronic intermittent l-DOPA treatment. No change in amplitude was found in DA-denervated sides of either dyskinetic or non-dyskinetic animals, while release kinetics were changed. This indicates the importance of studying DA release dynamics for the understanding of both beneficial and adverse effects of l-DOPA replacement therapy.
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af Bjerkén, SaraUmeå universitet,Institutionen för integrativ medicinsk biologi (IMB)(Swepub:umu)saaafn99
(författare)
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Cenci, Angela M.
(författare)
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Pomerleau, Francois
(författare)
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Gerhardt, Greg A.
(författare)
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Strömberg, IngridUmeå universitet,Institutionen för integrativ medicinsk biologi (IMB)(Swepub:umu)inst0001
(författare)
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Cenci Nilsson, AngelaLund University,Lunds universitet,Basala gangliernas patofysiologi,Forskargrupper vid Lunds universitet,Basal Ganglia Pathophysiology,Lund University Research Groups(Swepub:lu)mphy-ace
(författare)
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Umeå universitetInstitutionen för integrativ medicinsk biologi (IMB)
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of Neurochemistry: Wiley108:4, s. 998-10080022-30421471-4159
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