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Correlations betwee...
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Lindström, Annika,1953-Umeå universitet,Onkologi
(författare)
Correlations between serum progesterone and smoking, and the growth fraction of cervical squamous cell carcinoma
- Artikel/kapitelEngelska2000
Förlag, utgivningsår, omfång ...
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:umu-32590
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-32590URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:1938664URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-59215URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-25378URI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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BACKGROUND: Possible correlations between growth fraction of squamous cervical carcinomas and serum progesterone (se-P) concentrations, smoking habits and DNA ploidy were studied. MATERIALS AND METHODS: The DNA S-phase fraction (SPF), measured by flow cytometry was used as a marker of tumour growth in 103 cases of squamous cervical cancer stage IB-IV. DNA-ploidy (peridiploidy vs. aneuploidy), Se-P, se-Estradiol, smoking habits, parity, menopausal status, clinical stage and histopathological grading were compared to SPF < 14% vs. SPF > or = 14%. RESULTS: Aneuploidy, (odds ratio (OR) 10.0), se-P > or = 2.6 nmol/l (OR 7.5) and smoking (OR 3.0) were significantly associated with SPF > or = 14%, after adjustments for all factors included in the study. The association with se-P and smoking was attributed to an increased risk for the premenopausal women in the study. DISCUSSION: In this study an increased tumour growth was associated with increased leves of se-P, smoking and aneuploidy in women with invasive squamous cervical carcinoma. This study seems to experimentally confirm epidemiological studies, where smoking and long-term use of oral contraceptives have been linked to cervical neoplasms.
Ämnesord och genrebeteckningar
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MEDICINE
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MEDICIN
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onkologi
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Oncology
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Backström, TKarolinska Institutet
(författare)
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Hellberg, DanUppsala universitet,Institutionen för kvinnors och barns hälsa
(författare)
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Tribukait, B
(författare)
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Strang, Peter,1957-Östergötlands Läns Landsting,Linköpings universitet,Uppsala universitet,Institutionen för kvinnors och barns hälsa,Hälsouniversitetet,Palliativmediicin,LAH Linnea(Swepub:liu)petst78
(författare)
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Stendahl, UlfUmeå universitet,Onkologi
(författare)
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Umeå universitetOnkologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Anticancer Research20, s. 1-0250-70051791-7530
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Ingår i:Anticancer Res.20, s. 1-
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