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Plasma Bilirubin an...
Plasma Bilirubin and UGT1A1*28 Are Not Protective Factors Against First-Time Myocardial Infarction in a Prospective, Nested Case–Referent Setting
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- Ekblom, Kim, 1970- (författare)
- Umeå universitet,Klinisk kemi
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- Marklund, Stefan L (författare)
- Umeå universitet,Klinisk kemi
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- Jansson, Jan-Håkan (författare)
- Medicinkliniken, Skellefteå lasarett
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- Osterman, Pia (författare)
- Umeå universitet,Patologi
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- Hallmans, Göran (författare)
- Umeå universitet,Näringsforskning
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- Weinehall, Lars (författare)
- Umeå universitet,Epidemiologi och global hälsa
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- Hultdin, Johan (författare)
- Umeå universitet,Klinisk kemi
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(creator_code:org_t)
- Philadelphia, PA : Lippincott Williams & Wilkins, 2010
- 2010
- Engelska.
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Ingår i: Circulation. - Philadelphia, PA : Lippincott Williams & Wilkins. - 1942-325X .- 1942-3268. ; :3, s. 340-347
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Background: Bilirubin, an effective antioxidant, shows a large variation in levels between individuals and has been positively associated with reduced cardiovascular disease risk. A major reason for the variability is a common promoter polymorphism, UGT1A1*28, which reduces the transcription of the enzyme that conjugates bilirubin, UDP-glucuronosyltransferase 1A1. The aim of the study was to evaluate a possible protective effect of plasma bilirubin and the UGT1A1*28 polymorphism against myocardial infarction in a prospective case-referent setting.Methods and Results: 618 subjects with a first-ever myocardial infarction (median event age 60.5 years, median lag time 3.5 years) and 1184 matched referents were studied. Plasma bilirubin was lower in cases vs. referents. Despite a strong gene-dosage effect on bilirubin levels in both cases and referents, the UGT1A1*28 polymorphism did not influence the risk of myocardial infarction. Among multiple other variables, serum iron showed one of the strongest associations with bilirubin levels.Conclusion: We found no evidence for a protective effect of the UGT1A1*28 polymorphism against myocardial infarction and consequently neither for bilirubin. The lower bilirubin levels in cases might be caused by decreased production, increased degradation or increased elimination.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- bilirubin
- myocardial infarction
- risk factors
- epidemiology
- Epidemiology
- Epidemiologi
- Cardiovascular medicine
- Kardiovaskulär medicin
- Clinical Chemistry
- klinisk kemi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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