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Sökning: onr:"swepub:oai:DiVA.org:umu-34842" > Relative risks for ...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003405naa a2200469 4500
001oai:DiVA.org:umu-34842
003SwePub
008100621s2009 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-348422 URI
0247 a https://doi.org/10.1161/STROKEAHA.109.5478692 DOI
040 a (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Asplund, Kjellu Umeå universitet,Medicin4 aut0 (Swepub:umu)kjas0001
2451 0a Relative risks for stroke by age, sex, and population based on follow-up of 18 European populations in the MORGAM Project
264 1c 2009
338 a print2 rdacarrier
520 a BACKGROUND AND PURPOSE: Within the framework of the MOnica Risk, Genetics, Archiving and Monograph (MORGAM) Project, the variations in impact of classical risk factors of stroke by population, sex, and age were analyzed. METHODS: Follow-up data were collected in 43 cohorts in 18 populations in 8 European countries surveyed for cardiovascular risk factors. In 93 695 persons aged 19 to 77 years and free of major cardiovascular disease at baseline, total observation years were 1 234 252 and the number of stroke events analyzed was 3142. Hazard ratios were calculated by Cox regression analyses. RESULTS: Each year of age increased the risk of stroke (fatal and nonfatal together) by 9% (95% CI, 9% to 10%) in men and by 10% (9% to 10%) in women. A 10-mm Hg increase in systolic blood pressure involved a similar increase in risk in men (28%; 24% to 32%) and women (25%; 20% to 29%). Smoking conferred a similar excess risk in women (104%; 78% to 133%) and in men (82%; 66% to 100%). The effect of increasing body mass index was very modest. Higher high-density lipoprotein cholesterol levels decreased the risk of stroke more in women (hazard ratio per mmol/L 0.58; 0.49 to 0.68) than in men (0.80; 0.69 to 0.92). The impact of the individual risk factors differed somewhat between countries/regions with high blood pressure being particularly important in central Europe (Poland and Lithuania). CONCLUSIONS: Age, sex, and region-specific estimates of relative risks for stroke conferred by classical risk factors in various regions of Europe are provided. From a public health perspective, an important lesson is that smoking confers a high risk for stroke across Europe.
7001 a Karvanen, Juha4 aut
7001 a Giampaoli, Simona4 aut
7001 a Jousilahti, Pekka4 aut
7001 a Niemelä, Matti4 aut
7001 a Broda, Grazyna4 aut
7001 a Cesana, Giancarlo4 aut
7001 a Dallongeville, Jean4 aut
7001 a Ducimetriere, Pierre4 aut
7001 a Evans, Alun4 aut
7001 a Ferrières, Jean4 aut
7001 a Haas, Bernadette4 aut
7001 a Jorgensen, Torben4 aut
7001 a Tamosiunas, Abdonas4 aut
7001 a Vanuzzo, Diego4 aut
7001 a Wiklund, Per-Gunnaru Umeå universitet,Medicin4 aut0 (Swepub:umu)pewi0010
7001 a Yarnell, John4 aut
7001 a Kuulasmaa, Kari4 aut
7001 a Kulathinal, Sangita4 aut
7102 a Umeå universitetb Medicin4 org
7730 t Strokeg 40:7, s. 2319-2326q 40:7<2319-2326x 0039-2499x 1524-4628
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-34842
8564 8u https://doi.org/10.1161/STROKEAHA.109.547869

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