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Lymphoblastic T-cel...
Lymphoblastic T-cell lymphoma in mice is unaffected by Celecoxib as single agent or in combination with cyclophosphamide
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- Johansson, Ann-Sofie, 1967- (författare)
- Umeå universitet,Medicinsk och klinisk genetik,Onkologi
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- Pawelzik, Sven-Christian (författare)
- Karolinska Institutet
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- Larefalk, Åsa (författare)
- Umeå universitet,Medicinsk och klinisk genetik
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- Jakobsson, Per-Johan (författare)
- Karolinska Institutet
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- Holmberg, Dan (författare)
- Umeå universitet,Medicinsk och klinisk genetik
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- Lindskog, Magnus (författare)
- Karolinska Institutet,Uppsala universitet,Klinisk farmakologi,Centrum för klinisk forskning Dalarna
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(creator_code:org_t)
- 2009-07-21
- 2009
- Engelska.
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Ingår i: Leukemia and Lymphoma. - : Informa UK Limited. - 1042-8194 .- 1029-2403. ; 50:7, s. 1198-1203
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Celecoxib, an inhibitor of cyclooxygenase-2, is a promising novel antitumor agent with pleitropic mechanisms of action. Whereas this drug induces growth arrest and apoptosis of B-lymphoma cells, its effect against aggressive T-cell neoplasms remains to be studied. We therefore evaluated Celecoxib therapy of immunocompetent mice transplanted with lymphoblastic T-cell lymphomas. Oral Celecoxib in clinically relevant and non-toxic doses did not affect the degree of hypersplenism or the number of viable lymphoma cells. The clinical deterioration of Celecoxib-treated mice was not different from untreated controls. The impact of adding Celecoxib (60 mg/kg) to cyclophosphamide (200 mg/kg x 1, i.p.) was assessed but showed no benefit compared to cyclophosphamide alone. Thus, Celecoxib lacks effect against lymphoblastic T-cell lymphoma in mice.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- T-cell lymphoma
- mouse
- prostaglandins
- Celecoxib
- chemotherapy
- Oncology
- Onkologi
- Oncology
- onkologi
- MEDICINE
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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