Sökning: onr:"swepub:oai:DiVA.org:umu-35334" > A comprehensive stu...
Fältnamn | Indikatorer | Metadata |
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000 | 04682naa a2200613 4500 | |
001 | oai:DiVA.org:umu-35334 | |
003 | SwePub | |
008 | 100813s2010 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:121077222 | |
009 | oai:prod.swepub.kib.ki.se:121345743 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-353342 URI |
024 | 7 | a https://doi.org/10.3109/0284186X.2010.4809802 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1210772222 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1213457432 URI |
040 | a (SwePub)umud (SwePub)kid (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Andersson, Ulrikau Umeå universitet,Onkologi4 aut0 (Swepub:umu)ulan0002 |
245 | 1 0 | a A comprehensive study of the association between the EGFR and ERBB2 genes and glioma risk |
264 | 1 | b Informa Healthcare,c 2010 |
338 | a print2 rdacarrier | |
520 | a Glioma is the most common type of adult brain tumor and glioblastoma, its most aggressive form, has a dismal prognosis. Receptor tyrosine kinases such as the epidermal growth factor receptor (EGFR, ERBB2, ERBB3, ERBB4) family, and the vascular endothelial growth factor receptor (VEGFR), play a central role in tumor progression. We investigated the genetic variants of EGFR, ERBB2, VEGFR and their ligands, EGF and VEGF on glioma and glioblastoma risk. In addition, we evaluated the association of genetic variants of a newly discovered family of genes known to interact with EGFR: LRIG2 and LRIG3 with glioma and glioblastoma risk. Methods. We analyzed 191 tag single nucleotide polymorphisms (SNPs) capturing all common genetic variation of EGF, EGFR, ERBB2, LRIG2, LRIG3, VEGF and VEGFR2 genes. Material from four case-control studies with 725 glioma patients (329 of who were glioblastoma patients) and their 1 610 controls was used. Haplotype analyses were conducted using SAS/Genetics software. Results. Fourteen of the SNPs were significantly associated with glioma risk at p< 0.05, and 17 of the SNPs were significantly associated with glioblastoma risk at p< 0.05. In addition, we found that one EGFR haplotype was related to increased glioblastoma risk at p=0.009, Odds Ratio [OR] = 1.67 (95% confidence interval (CI): 1.14, 2.45). The Bonferroni correction made all p-values non-significant. One SNP, rs4947986 next to the intron/exon boundary of exon 7 in EGFR, was validated in an independent data set of 713 glioblastoma and 2 236 controls, [OR] = 1.42 (95% CI: 1.06,1.91). Discussion. Previous studies show that regulation of the EGFR pathway plays a role in glioma progression but the present study is the first to find that certain genotypes of the EGFR gene may be related to glioblastoma risk. Further studies are required to reinvestigate these findings and evaluate the functional significance. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
653 | a Oncology | |
653 | a Onkologi | |
653 | a onkologi | |
653 | a Oncology | |
700 | 1 | a Schwartzbaum, Judith4 aut |
700 | 1 | a Wiklund, Fredriku Karolinska Institutet4 aut |
700 | 1 | a Sjöström, Sarau Karolinska Institutet,Umeå universitet,Onkologi4 aut0 (Swepub:umu)sasj0005 |
700 | 1 | a Liu, Yanhong4 aut |
700 | 1 | a Tsavachidis, Spyros4 aut |
700 | 1 | a Ahlbom, Andersu Karolinska Institutet4 aut |
700 | 1 | a Auvinen, Anssi4 aut |
700 | 1 | a Collatz-Laier, Helle4 aut |
700 | 1 | a Feychting, Mariau Karolinska Institutet4 aut |
700 | 1 | a Johansen, Christoffer4 aut |
700 | 1 | a Kiuru, Anne4 aut |
700 | 1 | a Lönn, Stefan4 aut |
700 | 1 | a Schoemaker, Minouk J4 aut |
700 | 1 | a Swerdlow, Anthony J4 aut |
700 | 1 | a Henriksson, Rogeru Umeå universitet,Onkologi4 aut0 (Swepub:umu)rohe0003 |
700 | 1 | a Bondy, Melissa4 aut |
700 | 1 | a Melin, Beatriceu Umeå universitet,Onkologi4 aut0 (Swepub:umu)bema0010 |
710 | 2 | a Umeå universitetb Onkologi4 org |
773 | 0 | t Acta Oncologicad : Informa Healthcareg 12, s. 17-17q 49:6<767-775x 0284-186Xx 1651-226X |
773 | 0 | t NEURO-ONCOLOGYd : Informa Healthcareg 12, s. 17-17q 12<17-17x 1522-8517 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-35334 |
856 | 4 8 | u https://doi.org/10.3109/0284186X.2010.480980 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:121077222 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:121345743 |
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