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Sequential adjuvant...
Sequential adjuvant chemotherapy and radiotherapy in endometrial cancer-Results from two randomised studies.
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- Högberg, Thomas (författare)
- Lund University,Lunds universitet,Medicinsk onkologi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medical oncology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Signorelli, Mauro (författare)
- A Manzoni Hospital
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- de Oliveira, Carlos Freire (författare)
- University Hospital, Coimbra, Portugal
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- Fossati, Roldano (författare)
- Mario Negri Institute for Pharmacological Research
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- Lissoni, Andrea Alberto (författare)
- S Gerardo Hospital
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- Sorbe, Bengt (författare)
- Örebro University Hospital
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- Andersson, Håkan (författare)
- Gothenburg University Hospital
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- Grenman, Seija (författare)
- Turku University Hospital
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- Lundgren, Caroline (författare)
- Östergötlands Läns Landsting,Onkologiskt centrum
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Rosenberg, Per (författare)
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- Boman, Karin (författare)
- Umeå universitet,Onkologi,Umeå University Hospital
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- Tholander, Bengt (författare)
- Uppsala universitet,Enheten för onkologi,Karolinska Hospital
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- Scambia, Giovanni (författare)
- Gemelli Hospital
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- Reed, Nicholas (författare)
- University of Glasgow
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- Cormio, Gennaro (författare)
- University of Bari
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- Tognon, Germana (författare)
- Spedali Civil Brescia
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- Clarke, Jackie (författare)
- Belfast City Hospital
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- Sawicki, Tomasz (författare)
- Medical University of Gdansk
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- Zola, Paolo (författare)
- Mauriziano Hospital
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- Kristensen, Gunnar (författare)
- Norwegian Radium Hospital
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(creator_code:org_t)
- Elsevier, 2010
- 2010
- Engelska.
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Ingår i: European Journal of Cancer. - : Elsevier. - 0959-8049 .- 1879-0852. ; 46:13, s. 2422-2431
- Relaterad länk:
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http://rihuc.huc.min...
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https://portal.resea... (primary) (free)
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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Abstract
Ämnesord
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- INTRODUCTION: Endometrial cancer patients with high grade tumours, deep myometrial invasion or advanced stage disease have a poor prognosis. Randomised studies have demonstrated the prevention of loco-regional relapses with radiotherapy (RT) with no effect on overall survival (OS). The possible additive effect of chemotherapy (CT) remains unclear. Two randomised clinical trials (NSGO-EC-9501/EORTC-55991 and MaNGO ILIADE-III) were undertaken to clarify if sequential combination of chemotherapy and radiotherapy improves progression-free survival (PFS) in high-risk endometrial cancer. The two studies were pooled. METHODS: Patients (n=540; 534 evaluable) with operated endometrial cancer International Federation of Obstetrics and Gynaecology (FIGO) stage I-III with no residual tumour and prognostic factors implying high-risk were randomly allocated to adjuvant radiotherapy with or without sequential chemotherapy. RESULTS: In the NSGO/EORTC study, the combined modality treatment was associated with 36% reduction in the risk for relapse or death (hazard ratio (HR) 0.64, 95%confidence interval (CI) 0.41-0.99; P=0.04); two-sided tests were used. The result from the Gynaecologic Oncology group at the Mario Negri Institute (MaNGO)-study pointed in the same direction (HR 0.61), but was not significant. In the combined analysis, the estimate of risk for relapse or death was similar but with narrower confidence limits (HR 0.63, CI 0.44-0.89; P=0.009). Neither study showed significant differences in the overall survival. In the combined analysis, overall survival approached statistical significance (HR 0.69, CI 0.46-1.03; P=0.07) and cancer-specific survival (CSS) was significant (HR 0.55, CI 0.35-0.88; P=0.01). CONCLUSION: Addition of adjuvant chemotherapy to radiation improves progression-free survival in operated endometrial cancer patients with no residual tumour and a high-risk profile. A remaining question for future studies is if addition of radiotherapy to chemotherapy improves the results.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Adjuvant therapy
- Chemotherapy
- Radiotherapy
- Chemoradiotherapy
- Endometrial cancer
- Randomised clinical trial
- Oncology
- Onkologi
- MEDICINE
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Högberg, Thomas
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Signorelli, Maur ...
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de Oliveira, Car ...
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Fossati, Roldano
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Lissoni, Andrea ...
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Sorbe, Bengt
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visa fler...
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Andersson, Håkan
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Grenman, Seija
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Lundgren, Caroli ...
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Rosenberg, Per
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Boman, Karin
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Tholander, Bengt
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Scambia, Giovann ...
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Reed, Nicholas
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Cormio, Gennaro
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Tognon, Germana
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Clarke, Jackie
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Sawicki, Tomasz
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Zola, Paolo
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Kristensen, Gunn ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
- Artiklar i publikationen
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European Journal ...
- Av lärosätet
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Umeå universitet
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Lunds universitet
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Uppsala universitet
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