Obesity, inflammatory markers, and endometrial cancer risk: a prospective case-control study

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Fältnamn	Indikatorer	Metadata
000		04684naa a2200829 4500
001		oai:DiVA.org:umu-38253
003		SwePub
008		101202s2010 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-382532 URI
024	7	a https://doi.org/10.1677/ERC-10-00532 DOI
040		a (SwePub)umu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Dossus, Laure4 aut
245	1 0	a Obesity, inflammatory markers, and endometrial cancer risk :b a prospective case-control study
264	1	c 2010
338		a print2 rdacarrier
520		a Obesity, a major risk factor for endometrial cancer, is a low-grade inflammatory state characterized by elevated concentrations of cytokines and acute phase reactants. The current study had two aims: first to investigate the associations of C-reactive protein (CRP), interleukin 6 (IL6), and IL1 receptor antagonist (IL1Ra) with endometrial cancer risk and second to examine to which extent these markers can influence the association between obesity and endometrial cancer. We conducted a case-control study, nested within the European Prospective Investigation into Cancer and Nutrition, which comprised 305 incident cases of endometrial cancer and 574 matched controls. CRP, IL6, and IL1Ra were measured in prospectively collected blood specimens by immunoassays. Data were analyzed using conditional logistic regression. All statistical tests were two-sided, and P values <0.05 were considered statistically significant. We observed a significant increase in risk of endometrial cancer with elevated levels of CRP (odds ratio (OR) for top versus bottom quartile: 1.58, 95% confidence interval (CI): 1.03-2.41, P(trend)=0.02), IL6 (OR for top versus bottom quartile: 1.66, 95% CI: 1.08-2.54, P(trend)=0.008), and IL1Ra (OR for top versus bottom quartile: 1.82, 95% CI: 1.22-2.73, P(trend)=0.004). After adjustment for body mass index (BMI), the estimates were strongly reduced and became non-significant. The association between BMI and endometrial cancer was also substantially attenuated (∼10-20%) after adjustment for inflammatory markers, even when the effects of C-peptide or estrone had already been taken into account. We provided epidemiological evidence that chronic inflammation might mediate the association between obesity and endometrial cancer and that endometrial carcinogenesis could be promoted by an inflammatory milieu.
653		a MEDICINE
653		a MEDICIN
653		a Pathology
653		a patologi
700	1	a Rinaldi, Sabina4 aut
700	1	a Becker, Susen4 aut
700	1	a Lukanova, Annekatrin4 aut
700	1	a Tjonneland, Anne4 aut
700	1	a Olsen, Anja4 aut
700	1	a Stegger, Jakob4 aut
700	1	a Overvad, Kim4 aut
700	1	a Chabbert-Buffet, Nathalie4 aut
700	1	a Jimenez-Corona, Aida4 aut
700	1	a Clavel-Chapelon, Francoise4 aut
700	1	a Rohrmann, Sabine4 aut
700	1	a Teucher, Birgit4 aut
700	1	a Boeing, Heiner4 aut
700	1	a Schütze, Madlen4 aut
700	1	a Trichopoulou, Antonia4 aut
700	1	a Benetou, Vassiliki4 aut
700	1	a Lagiou, Pagona4 aut
700	1	a Palli, Domenico4 aut
700	1	a Berrino, Franco4 aut
700	1	a Panico, Salvatore4 aut
700	1	a Tumino, Rosario4 aut
700	1	a Sacerdote, Carlotta4 aut
700	1	a Redondo, Maria-Luisa4 aut
700	1	a Travier, Noémie4 aut
700	1	a Sanchez, Maria-Jose4 aut
700	1	a Altzibar, Jone M4 aut
700	1	a Chirlaque, Maria-Dolores4 aut
700	1	a Ardanaz, Eva4 aut
700	1	a Bueno-de-Mesquita, H Bas4 aut
700	1	a van Duijnhoven, Fränzel J B4 aut
700	1	a Onland-Moret, N Charlotte4 aut
700	1	a Peeters, Petra H M4 aut
700	1	a Hallmans, Göran,d 1947-u Umeå universitet,Näringsforskning4 aut0 (Swepub:umu)goha0001
700	1	a Lundin, Evau Umeå universitet,Patologi4 aut0 (Swepub:umu)evlu0001
700	1	a Khaw, Kay-Tee4 aut
700	1	a Wareham, Nicholas4 aut
700	1	a Allen, Naomi4 aut
700	1	a Key, Tim J4 aut
700	1	a Slimani, Nadia4 aut
700	1	a Hainaut, Pierre4 aut
700	1	a Romaguera, Dora4 aut
700	1	a Norat, Teresa4 aut
700	1	a Riboli, Elio4 aut
700	1	a Kaaks, Rudolf4 aut
710	2	a Umeå universitetb Näringsforskning4 org
773	0	t Endocrine-Related Cancerg 17:4, s. 1007-1019q 17:4<1007-1019x 1351-0088x 1479-6821
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-38253
856	4 8	u https://doi.org/10.1677/ERC-10-0053

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Av författaren/redakt...: Dossus, Laure; Rinaldi, Sabina; Becker, Susen; Lukanova, Anneka ...; Tjonneland, Anne; Olsen, Anja; visa fler...; Stegger, Jakob; Overvad, Kim; Chabbert-Buffet, ...; Jimenez-Corona, ...; Clavel-Chapelon, ...; Rohrmann, Sabine; Teucher, Birgit; Boeing, Heiner; Schütze, Madlen; Trichopoulou, An ...; Benetou, Vassili ...; Lagiou, Pagona; Palli, Domenico; Berrino, Franco; Panico, Salvator ...; Tumino, Rosario; Sacerdote, Carlo ...; Redondo, Maria-L ...; Travier, Noémie; Sanchez, Maria-J ...; Altzibar, Jone M; Chirlaque, Maria ...; Ardanaz, Eva; Bueno-de-Mesquit ...; van Duijnhoven, ...; Onland-Moret, N ...; Peeters, Petra H ...; Hallmans, Göran, ...; Lundin, Eva; Khaw, Kay-Tee; Wareham, Nichola ...; Allen, Naomi; Key, Tim J; Slimani, Nadia; Hainaut, Pierre; Romaguera, Dora; Norat, Teresa; Riboli, Elio; Kaaks, Rudolf; visa färre...

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