Increased content of bombesin/GRP in human synovial fluid in early arthritis: different pattern compared with substance P

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Fältnamn	Indikatorer	Metadata
000		03618naa a2200337 4500
001		oai:DiVA.org:umu-39168
003		SwePub
008		110118s2001 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-391682 URI
040		a (SwePub)umu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Westermark, Tu Umeå universitet,Anatomi4 aut
245	1 0	a Increased content of bombesin/GRP in human synovial fluid in early arthritis :b different pattern compared with substance P
264	1	c 2001
338		a print2 rdacarrier
520		a Objective Bombesin (BN) and the mammalian homologue gastrin-releasing peptide (GRP) are known trophic factors, neurotransmitters and paracrine hormones. BN/GRP has not previously been demonstrated in synovial fluid. In this study, the amounts of BN/GRP and substance P (SP) present in synovial fluid from the knee joints of patients with rheumatoid arthritis (RA) and of healthy, controls were measured. Methods Synovial fluid from the knee joint was collected from patients with either longstanding RA (n = 32) or early arthritis (symptoms for < 12 months; n = 9) and from control subjects, i.e., individuals without known joint disease (n = 10). These samples were analyzed using radioimmunoassays. Results Levels of BN/GRP-like peptide were below the assay detection limits in synovial fluid from controls. Detectable levels of immunoreactive BN/GRP were present in the majority of patients with either longstanding RA or early arthritis. The levels were significantly higher in the synovial fluid from patients classified as having early, arthritis compared with those with longstanding RA (p < 0.05). There was a strong correlation between BN/GRP levels and the number of leukocytes in the synovial fluid in the patients with early arthritis. The levels of SP-like peptide in the patients, whether with early arthritis or longstanding RA, were significantly elevated compared with controls. However there was no difference in the levels between these two patient groups. Conclusions These observations show that BN/GRP-like peptide is present in the synovial fluid of joints affected by arthritis and that the pattern of BN/GRP increase differs from that of SP It appears as if the presence of BN/GRP is particularly related to the early processes of joint involvement. These observations are of interest because BN/GRP has well-known trophic and paracrine effects and chondrocytes have recently been shown to produce neuropeptides such as BN/GRP.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng
653		a rheumatoid arthritis; synovial fluid; neuropeptides; BN/GRP; substance P; inflammation
653		a Rheumatology
653		a Reumatologi
700	1	a Rantapää-Dahlqvist, Solbrittu Umeå universitet,Reumatologi4 aut0 (Swepub:umu)sora0001
700	1	a Wållberg-Jonsson, Solveigu Umeå universitet,Reumatologi4 aut0 (Swepub:umu)sowa0001
700	1	a Kjörell, Uu Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB)4 aut
700	1	a Forsgren, Stureu Umeå universitet,Anatomi4 aut0 (Swepub:umu)stfo0001
710	2	a Umeå universitetb Anatomi4 org
773	0	t Clinical and Experimental Rheumatologyg 19:6, s. 715-720q 19:6<715-720x 0392-856Xx 1593-098X
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-39168

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