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Increase in bombesi...
Increase in bombesin-like peptides in the spinal cord after dexamethasone treatment of adrenalectomized rats
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- Westermark, T (författare)
- Umeå universitet,Anatomi
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- Isaksson, T (författare)
- Umeå universitet,Anatomi
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- Holmberg, P (författare)
- Umeå universitet,Anatomi
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- Kjörell, U (författare)
- Umeå universitet,Anatomi
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- Rantapää-Dahlqvist, Solbritt (författare)
- Umeå universitet,Reumatologi
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- Forsgren, Sture (författare)
- Umeå universitet,Anatomi
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(creator_code:org_t)
- 1999
- 1999
- Engelska.
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Ingår i: Neuroscience Letters. - 0304-3940 .- 1872-7972. ; 275:3, s. 179-182
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The potential influence of corticosteroids on the bombesin (BN)-like peptide family is unknown. Therefore, the effects of adrenalectomy (ADX) on the nervous system of Sprague-Dawley rats, some of them being treated with high doses of the synthetic glucocorticoid dexamethasone (DEX), were investigated. After 8-10 days of treatment, the rats were sacrificed and tissues were prepared for radioimmunoassay (RIA) and immunohistochemical examination. We found an increase in BN-like immunoreactivity in the superficial layers of the dorsal horn of the lumbar spinal cord in the ADX + DEX animals. This increase was confirmed by RIA (P < 0.05). The observations show that the expression of BN-like peptides is influenced by glucocorticoids. The altered levels of BN-like peptides may be related to the trophic and antinociceptive effects previously reported for these peptides. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Nyckelord
- rat; adrenalectomy; dexamethasone; glucocorticoids; steroids; bombesin; neuropeptides
- Rheumatology
- Reumatologi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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