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Targeting castratio...
Targeting castration-induced tumour hypoxia enhances the acute effects of castration therapy in a rat prostate cancer model
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- Johansson, Anna (författare)
- Umeå universitet,Patologi,Urologi och andrologi
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Rudolfsson, Stina Häggström (författare)
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- Kilter, Sigrid (författare)
- Umeå universitet,Patologi
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- Bergh, Anders (författare)
- Umeå universitet,Patologi
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(creator_code:org_t)
- 2011
- 2011
- Engelska.
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Ingår i: BJU International. - 1464-4096 .- 1464-410X. ; 107:11, s. 1818-1824
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- OBJECTIVE: • To explore the effects of castration therapy, the standard treatment for advanced prostate cancer, in relation to tumour hypoxia and to elicit its importance for the short- and long-term therapeutic response. MATERIAL AND METHODS: • We used the androgen-sensitive rat Dunning H prostate tumour model that transiently responds to castration treatment followed by a subsequent relapse, much like the scenario in human patients. • Tumour tissues were analysed using stereological methods in intact, 1 and 7 days after castration therapy. RESULTS: • Hypoxia was transiently up-regulated after castration therapy and correlated with the induction of tumour cell apoptosis. • When castration therapy was combined with tirapazamine (TPZ), a drug that targets hypoxic cells and the vasculature, the effects on tumour cell apoptosis and tumour volume were enhanced in comparison to either castration or TPZ alone. CONCLUSION: • The present study suggests that castration-induced tumour hypoxia is a novel target for therapy.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Nyckelord
- hypoxia;castration;tirapazamine;prostate;Dunning H
- Pathology
- Patologi
- Pathology
- patologi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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